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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of translation initiation in response to endoplasmic reticulum stress
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Accession:GO:0036491 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress.
Synonyms:exact_synonym: regulation of translation initiation in response to ER stress


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eiF2alpha phosphorylation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO
ISS
(PMID:25329545)
(MGI:6467680|PMID:17707796)
GO_REF:0000024
RGD
UniProt
PMID:17707796, PMID:25329545 GO_REF:0000024, MGI:6467680 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (PMID:25329545) RGD PMID:25329545 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISO
ISS
(PMID:22064321)
(MGI:5617428|PMID:25329545)
GO_REF:0000024
RGD
UniProt
PMID:22064321, PMID:25329545 GO_REF:0000024, MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213), (PMID:16835242)
UniProtKB:O55033 (MGI:5613475|PMID:16835242), (MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:16835242 MGI:5613475, MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO (PMID:16835242)
UniProtKB:Q99M51 (MGI:5613475|PMID:16835242), (MGI:5613478|PMID:14676213)
RGD PMID:14676213, PMID:16835242 MGI:5613475, MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B ISO (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (PMID:21518769) RGD PMID:21518769 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
positive regulation of translation initiation in response to endoplasmic reticulum stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISS
ISO
GO_REF:0000024
(MGI:5617428|PMID:25329545)
UniProt
RGD
PMID:25329545 GO_REF:0000024, MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISS
ISO
GO_REF:0000024
(MGI:3582244|PMID:11106749)
UniProt
RGD
PMID:11106749 GO_REF:0000024, MGI:3582244 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO (MGI:5605960|PMID:11381086) RGD PMID:11381086 MGI:5605960 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to stress 4062
        cellular response to stress 1981
          response to endoplasmic reticulum stress 261
            regulation of translation in response to endoplasmic reticulum stress 11
              regulation of translation initiation in response to endoplasmic reticulum stress 8
                eIF2alpha dephosphorylation in response to endoplasmic reticulum stress + 1
                eiF2alpha phosphorylation in response to endoplasmic reticulum stress + 8
                negative regulation of translation initiation in response to endoplasmic reticulum stress 0
                positive regulation of translation initiation in response to endoplasmic reticulum stress 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      nitrogen compound metabolic process 10347
        cellular nitrogen compound metabolic process 6684
          cellular amide metabolic process 1510
            peptide metabolic process 1269
              peptide biosynthetic process 1114
                translation 1096
                  regulation of translation 382
                    regulation of translation in response to stress 22
                      regulation of translation in response to endoplasmic reticulum stress 11
                        regulation of translation initiation in response to endoplasmic reticulum stress 8
                          eIF2alpha dephosphorylation in response to endoplasmic reticulum stress + 1
                          eiF2alpha phosphorylation in response to endoplasmic reticulum stress + 8
                          negative regulation of translation initiation in response to endoplasmic reticulum stress 0
                          positive regulation of translation initiation in response to endoplasmic reticulum stress 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.