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ONTOLOGY REPORT - ANNOTATIONS


Term:IRE1-mediated unfolded protein response
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Accession:GO:0036498 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Comment:Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
Synonyms:exact_synonym: IRE1 branch of UPR;   UPR signaling by IRE1 stress sensor;   endoplasmic reticulum unfolded protein response; IRE1 signaling
 narrow_synonym: IRE1alpha unfolded protein response;   IRE1p unfolded protein response
 broad_synonym: IRE1 signal transduction pathway
 related_synonym: ERN1-mediated unfolded protein response;   IRE1 signaling in response to endoplasmic reticulum stress;   inositol-requiring enzyme 1-mediated unfolded protein response;   inositol-requiring transmembrane kinase/endonuclease signal transduction


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IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:13792537
RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Parp16 poly (ADP-ribose) polymerase family, member 16 JBrowse link 8 70,712,393 70,731,212 RGD:1600115
RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1600115
RGD:1624291
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bfar bifunctional apoptosis regulator JBrowse link 10
10
1,464,658
1,464,783
1,471,152
1,497,653
RGD:1624291
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1624291
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 6 64,165,913 64,170,122 RGD:1600115
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1600115
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:1624291
G Ufl1 Ufm1-specific ligase 1 JBrowse link 5 39,616,479 39,650,894 RGD:1624291
RGD:1600115
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
G Ficd FIC domain protein adenylyltransferase JBrowse link 12 48,658,283 48,663,175 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      signal transduction 6968
        endoplasmic reticulum unfolded protein response 72
          IRE1-mediated unfolded protein response 15
            negative regulation of IRE1-mediated unfolded protein response 6
            positive regulation of IRE1-mediated unfolded protein response 2
            regulation of IRE1-mediated unfolded protein response + 10
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      cellular response to stimulus 8858
        cellular response to chemical stimulus 3497
          cellular response to organic substance 2825
            cellular response to topologically incorrect protein 122
              cellular response to unfolded protein 99
                endoplasmic reticulum unfolded protein response 72
                  IRE1-mediated unfolded protein response 15
                    negative regulation of IRE1-mediated unfolded protein response 6
                    positive regulation of IRE1-mediated unfolded protein response 2
                    regulation of IRE1-mediated unfolded protein response + 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.