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ONTOLOGY REPORT - ANNOTATIONS


Term:IRE1-mediated unfolded protein response
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Accession:GO:0036498 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Comment:Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
Synonyms:exact_synonym: IRE1 branch of UPR;   UPR signaling by IRE1 stress sensor;   endoplasmic reticulum unfolded protein response; IRE1 signaling
 narrow_synonym: IRE1alpha unfolded protein response;   IRE1p unfolded protein response
 broad_synonym: IRE1 signal transduction pathway
 related_synonym: ERN1-mediated unfolded protein response;   IRE1 signaling in response to endoplasmic reticulum stress;   inositol-requiring enzyme 1-mediated unfolded protein response;   inositol-requiring transmembrane kinase/endonuclease signal transduction


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Path 1
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  biological_process 0
    cellular process 0
      signal transduction 0
        endoplasmic reticulum unfolded protein response 0
          IRE1-mediated unfolded protein response 0
            negative regulation of IRE1-mediated unfolded protein response 0
            positive regulation of IRE1-mediated unfolded protein response 0
            regulation of IRE1-mediated unfolded protein response + 0
Path 2
Term Annotations click to browse term
  biological_process 0
    response to stimulus 0
      cellular response to stimulus 0
        cellular response to chemical stimulus 0
          cellular response to organic substance 0
            cellular response to topologically incorrect protein 0
              cellular response to unfolded protein 0
                endoplasmic reticulum unfolded protein response 0
                  IRE1-mediated unfolded protein response 0
                    negative regulation of IRE1-mediated unfolded protein response 0
                    positive regulation of IRE1-mediated unfolded protein response 0
                    regulation of IRE1-mediated unfolded protein response + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.