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ONTOLOGY REPORT - ANNOTATIONS


Term:ATF6-mediated unfolded protein response
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Accession:GO:0036500 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Synonyms:exact_synonym: ATF6 branch of UPR;   UPR signaling by ATF6 stress sensor;   activating transcription factor 6 signaling in unfolded protein response;   endoplasmic reticulum unfolded protein response; ATF6 signaling
 narrow_synonym: ATF6-alpha UPR branch;   ATF6-beta UPR branch
 broad_synonym: ATF6 signal transduction pathway
 related_synonym: ATF6 signaling in response to endoplasmic reticulum stress


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negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein ISO
IGI
(PMID:20160352) RGD PMID:20160352, PMID:20160352 RGD:10047363 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 ISO (PMID:9837962) RGD PMID:9837962 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      signal transduction 7011
        endoplasmic reticulum unfolded protein response 74
          ATF6-mediated unfolded protein response 3
            negative regulation of ATF6-mediated unfolded protein response 2
            positive regulation of ATF6-mediated unfolded protein response 1
            regulation of ATF6-mediated unfolded protein response + 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        cellular response to chemical stimulus 3528
          cellular response to organic substance 2845
            cellular response to topologically incorrect protein 125
              cellular response to unfolded protein 101
                endoplasmic reticulum unfolded protein response 74
                  ATF6-mediated unfolded protein response 3
                    negative regulation of ATF6-mediated unfolded protein response 2
                    positive regulation of ATF6-mediated unfolded protein response 1
                    regulation of ATF6-mediated unfolded protein response + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.