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ONTOLOGY REPORT - ANNOTATIONS


Term:ERAD pathway
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Accession:GO:0036503 term browser browse the term
Definition:The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
Synonyms:exact_synonym: endoplasmic reticulum-associated degradation;   protein degradation by ERAD
 related_synonym: ER-associated degradation pathway;   endoplasmic reticulum-associated protein degradation pathway


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ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brsk2 BR serine/threonine kinase 2 ISO
IEA
(PMID:23907667)
GO_REF:0000107
RGD
Ensembl
PMID:23907667 GO_REF:0000107 NCBI chr 1:214,918,757...214,940,883
Ensembl chr 1:214,927,172...214,947,624
JBrowse link
G Ccdc47 coiled-coil domain containing 47 ISS
ISO
GO_REF:0000024
(PMID:25009997)
UniProt
RGD
PMID:25009997 GO_REF:0000024 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Derl1 derlin 1 ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 ISO (PMID:21148293), (PMID:21150129) RGD PMID:21148293, PMID:21150129 NCBI chr20:29,445,510...29,463,739
Ensembl chr20:29,445,510...29,463,738
JBrowse link
G Rcn3 reticulocalbin 3 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:6201885|PMID:26252542)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26252542 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6201885 NCBI chr 1:101,076,971...101,086,198
Ensembl chr 1:101,076,898...101,086,198
JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISO
ISS
(MGI:MGI:5437551|PMID:22795130)
GO_REF:0000024
RGD
UniProt
PMID:22795130 GO_REF:0000024, MGI:MGI:5437551 NCBI chr 9:88,110,731...88,229,462
Ensembl chr 9:88,110,731...88,229,479
JBrowse link
G Rnf139 ring finger protein 139 ISO
IBA
(PMID:25239945)
PMID:21873635
RGD PMID:25239945, PMID:21873635 RGD:13792537 NCBI chr 7:98,770,840...98,782,025
Ensembl chr 7:98,770,840...98,782,025
JBrowse link
G Rnf185 ring finger protein 185 ISO UniProtKB:Q99942 (PMID:24019521) RGD PMID:24019521 NCBI chr14:83,648,400...83,685,273
Ensembl chr14:83,648,402...83,685,273
JBrowse link
G Rnf5 ring finger protein 5 ISO (PMID:24019521) RGD PMID:24019521 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ISO
ISS
(MGI:MGI:5606246|PMID:25066055)
(PMID:21454652), (PMID:26471130)
GO_REF:0000024
RGD
UniProt
PMID:21454652, PMID:25066055, PMID:26471130 GO_REF:0000024, MGI:MGI:5606246 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Syvn1 synoviolin 1 ISO (MGI:MGI:5645202|PMID:21454652)
(PMID:22590560), (PMID:26471130)
RGD PMID:21454652, PMID:22590560, PMID:26471130 MGI:MGI:5645202 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Ubxn6 UBX domain protein 6 ISO (PMID:19275885) RGD PMID:19275885 NCBI chr 9:10,995,516...11,000,643
Ensembl chr 9:10,995,198...11,000,642
JBrowse link
G Vcp valosin-containing protein ISS
ISO
GO_REF:0000024
(PMID:20104022), (PMID:25088257)
UniProt
RGD
PMID:20104022, PMID:25088257 GO_REF:0000024 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
ER-associated misfolded protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor ISO
ISS
(PMID:21857022)
GO_REF:0000024
RGD
UniProt
PMID:21857022 GO_REF:0000024 NCBI chr 4:113,887,030...113,890,103
Ensembl chr 4:113,887,115...113,890,101
JBrowse link
G Bag6 BAG cochaperone 6 ISS
ISO
GO_REF:0000024
(PMID:23129660), (PMID:24981174)
UniProt
RGD
PMID:23129660, PMID:24981174 GO_REF:0000024 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Derl1 derlin 1 ISO (PMID:24089527) RGD PMID:24089527 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Ngly1 N-glycanase 1 IDA RGD PMID:32259258 RGD:39457703 NCBI chr15:10,405,453...10,455,973
Ensembl chr15:10,405,164...10,455,956
JBrowse link
G Pomt2 protein-O-mannosyltransferase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:111,137,329...111,176,991
Ensembl chr 6:111,135,349...111,176,918
JBrowse link
G Rnf185 ring finger protein 185 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,648,400...83,685,273
Ensembl chr14:83,648,402...83,685,273
JBrowse link
G Rnf5 ring finger protein 5 ISO
IBA
(PMID:19269966)
PMID:21873635
RGD PMID:19269966, PMID:21873635 RGD:13792537 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Sdf2 stromal cell derived factor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:65,507,364...65,517,839
Ensembl chr10:65,507,364...65,517,838
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 IMP PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Tor1a torsin family 1, member A ISO
ISS
(MGI:MGI:3712415|PMID:17200151)
GO_REF:0000024
RGD
UniProt
PMID:17200151 GO_REF:0000024, MGI:MGI:3712415 NCBI chr 3:9,800,322...9,807,318
Ensembl chr 3:9,800,322...9,807,328
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO
IBA
(PMID:24089527)
PMID:21873635
RGD PMID:24089527, PMID:21873635 RGD:13792537 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:42,692,156...42,805,680
Ensembl chr 9:42,692,105...42,805,673
JBrowse link
G Vcp valosin-containing protein ISO
IBA
(PMID:24089527)
PMID:21873635
RGD PMID:24089527, PMID:21873635 RGD:13792537 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
maintenance of unfolded protein involved in ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag6 BAG cochaperone 6 ISO (PMID:21636303) RGD PMID:21636303 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 ISO (PMID:21636303) RGD PMID:21636303 NCBI chr12:17,469,112...17,486,709
Ensembl chr12:17,469,112...17,486,157
JBrowse link
G Usp13 ubiquitin specific peptidase 13 ISO (PMID:24424410) RGD PMID:24424410 NCBI chr 2:119,197,153...119,317,507
Ensembl chr 2:119,197,239...119,317,500
JBrowse link
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 ISO (PMID:25092655) RGD PMID:25092655 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 ISO (PMID:25092655) RGD PMID:25092655 NCBI chr 3:151,232,741...151,258,559
Ensembl chr 3:151,232,751...151,258,580
JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 ISO (PMID:25092655)
(MGI:MGI:3654428|PMID:16431915)
RGD PMID:16431915, PMID:25092655 MGI:MGI:3654428 NCBI chr13:69,135,095...69,197,708
Ensembl chr13:69,135,128...69,199,511
JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:35,257,688...35,450,132
Ensembl chr20:35,257,985...35,450,513
JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 ISO (PMID:18003979), (PMID:21062743) RGD PMID:18003979, PMID:21062743 NCBI chr 3:2,547,259...2,569,051
Ensembl chr 3:2,547,986...2,569,049
JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 3:148,150,695...148,189,623
Ensembl chr 3:148,150,698...148,189,623
JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISO (MGI:MGI:5437551|PMID:22795130) RGD PMID:22795130 MGI:MGI:5437551 NCBI chr 9:88,110,731...88,229,462
Ensembl chr 9:88,110,731...88,229,479
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO
ISS
(PMID:23129660)
GO_REF:0000024
RGD
UniProt
PMID:23129660 GO_REF:0000024 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Svip small VCP interacting protein IC
IBA
ISO
PMID:17000876
PMID:21873635
(PMID:17872946)
RGD PMID:17872946, PMID:17000876, PMID:21873635 RGD:10047192, RGD:13792537 NCBI chr 1:107,368,117...107,373,807
Ensembl chr 1:107,368,117...107,373,807
JBrowse link
G Usp14 ubiquitin specific peptidase 14 ISO (PMID:19135427) RGD PMID:19135427 NCBI chr18:1,178,785...1,216,573
Ensembl chr18:1,178,787...1,216,409
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 ISS
ISO
GO_REF:0000024
(MGI:MGI:3813160|PMID:18606867)
UniProt
RGD
PMID:18606867 GO_REF:0000024, MGI:MGI:3813160 NCBI chr 1:162,703,394...162,713,560
Ensembl chr 1:162,703,442...162,713,610
JBrowse link
G Ubxn1 UBX domain protein 1 ISO (PMID:21135095) RGD PMID:21135095 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO (PMID:22590560) RGD PMID:22590560 NCBI chr11:15,436,080...15,558,646
Ensembl chr11:15,436,269...15,558,646
JBrowse link
negative regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Derl2 derlin 2 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr10:57,641,682...57,653,554
Ensembl chr10:57,644,207...57,653,359
JBrowse link
G Derl3 derlin 3 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205
JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr14:115,314,890...115,352,871
Ensembl chr14:115,314,890...115,352,562
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 7:70,378,625...70,407,135
Ensembl chr 7:70,380,311...70,407,177
JBrowse link
G Svip small VCP interacting protein ISO
IBA
(PMID:25660456)
PMID:21873635
RGD PMID:25660456, PMID:21873635 RGD:13792537 NCBI chr 1:107,368,117...107,373,807
Ensembl chr 1:107,368,117...107,373,807
JBrowse link
G Ubac2 UBA domain containing 2 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr15:108,286,407...108,433,531
Ensembl chr15:108,286,453...108,433,529
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:11,700,089...11,721,823
Ensembl chr20:11,700,089...11,721,838
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 5:48,274,387...48,292,699
Ensembl chr 5:48,274,477...48,290,658
JBrowse link
G Yod1 YOD1 deubiquitinase ISO (PMID:24068323) RGD PMID:24068323 NCBI chr13:47,441,296...47,443,013
Ensembl chr13:47,440,803...47,443,188
JBrowse link
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B-cell receptor-associated protein 31 ISO UniProtKB:Q9BUN8 (PMID:18555783) RGD PMID:18555783 NCBI chr  X:157,094,365...157,126,397
Ensembl chr  X:157,095,937...157,126,393
JBrowse link
G Cav1 caveolin 1 IEA
ISO
GO_REF:0000107
(PMID:24089527)
Ensembl
RGD
PMID:24089527 GO_REF:0000107 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISS
ISO
PMID:22045699
(PMID:18307982), (PMID:22045699)
RGD PMID:18307982, PMID:22045699, PMID:22045699 RGD:10047316 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23246001) RGD PMID:23246001 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Ubqln1 ubiquilin 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:18307982)
Ensembl
UniProt
RGD
PMID:18307982 GO_REF:0000024, GO_REF:0000107 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
G Ubqln2 ubiquilin 2 ISO (PMID:18307982) RGD PMID:18307982 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732
JBrowse link
positive regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 ISO (PMID:17000876) RGD PMID:17000876 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461
JBrowse link
G Bag6 BAG cochaperone 6 ISO (PMID:24424410) RGD PMID:24424410 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Rnf185 ring finger protein 185 ISS
ISO
GO_REF:0000024
(PMID:27485036)
UniProt
RGD
PMID:27485036 GO_REF:0000024 NCBI chr14:83,648,400...83,685,273
Ensembl chr14:83,648,402...83,685,273
JBrowse link
G Rnft1 ring finger protein, transmembrane 1 ISO (PMID:27485036) RGD PMID:27485036 NCBI chr10:73,807,455...73,821,178
Ensembl chr10:73,809,157...73,817,982
JBrowse link
G Tmem259 transmembrane protein 259 ISO
IBA
(MGI:MGI:5648655|PMID:25977983)
PMID:21873635
RGD PMID:25977983, PMID:21873635 MGI:MGI:5648655, RGD:13792537 NCBI chr 7:12,771,239...12,777,901
Ensembl chr 7:12,771,227...12,779,862
JBrowse link
G Tmem67 transmembrane protein 67 IMP RGD PMID:19815549 RGD:8554391 NCBI chr 5:25,666,138...25,721,056
Ensembl chr 5:25,666,137...25,721,072
JBrowse link
G Usp13 ubiquitin specific peptidase 13 ISO (PMID:24424410) RGD PMID:24424410 NCBI chr 2:119,197,153...119,317,507
Ensembl chr 2:119,197,239...119,317,500
JBrowse link
positive regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B-cell receptor-associated protein 31 ISO (PMID:18555783) RGD PMID:18555783 NCBI chr  X:157,094,365...157,126,397
Ensembl chr  X:157,095,937...157,126,393
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 ISO UniProtKB:Q9BV94 (PMID:24200403)
(MGI:MGI:5563002|PMID:24200403)
RGD PMID:24200403 MGI:MGI:5563002 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 ISO UniProtKB:Q92611 (PMID:24200403)
(MGI:MGI:5563002|PMID:24200403)
RGD PMID:24200403 MGI:MGI:5563002 NCBI chr 3:151,232,741...151,258,559
Ensembl chr 3:151,232,751...151,258,580
JBrowse link
protein localization to cytosolic proteasome complex involved in ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 ISO (PMID:17000876) RGD PMID:17000876 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461
JBrowse link
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO
IBA
(MGI:MGI:5613477|PMID:15147274)
PMID:21873635
RGD PMID:15147274, PMID:21873635 MGI:MGI:5613477, RGD:13792537 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Usp19 ubiquitin specific peptidase 19 ISO
IEA
(PMID:25088257)
GO_REF:0000107
RGD
Ensembl
PMID:25088257 GO_REF:0000107 NCBI chr 8:117,280,690...117,291,729
Ensembl chr 8:117,280,705...117,291,351
JBrowse link
retrograde protein transport, ER to cytosol term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 4:113,887,030...113,890,103
Ensembl chr 4:113,887,115...113,890,101
JBrowse link
G Derl1 derlin 1 ISO (PMID:15215855), (PMID:15215856), (PMID:25660456) RGD PMID:15215855, PMID:15215856, PMID:25660456 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Derl2 derlin 2 ISO MGI:MGI:4947129 (MGI:MGI:4947015|PMID:21220515)
(PMID:16449189)
RGD PMID:16449189, PMID:21220515 MGI:MGI:4947015 NCBI chr10:57,641,682...57,653,554
Ensembl chr10:57,644,207...57,653,359
JBrowse link
G Faf2 Fas associated factor family member 2 ISO
IEA
(PMID:25660456)
GO_REF:0000107
RGD
Ensembl
PMID:25660456 GO_REF:0000107 NCBI chr17:10,485,650...10,527,886
Ensembl chr17:10,485,642...10,527,864
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO
IEA
(PMID:25660456)
GO_REF:0000107
RGD
Ensembl
PMID:25660456 GO_REF:0000107 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor ISO
ISS
IEA
(PMID:25660456)
GO_REF:0000024
GO_REF:0000107
RGD
ParkinsonsUK-UCL
Ensembl
PMID:25660456 GO_REF:0000024, GO_REF:0000107 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,378,625...70,407,135
Ensembl chr 7:70,380,311...70,407,177
JBrowse link
G Sec61b SEC61 translocon subunit beta ISO (PMID:17215517) RGD PMID:17215517 NCBI chr 5:63,192,322...63,200,532
Ensembl chr 5:63,192,298...63,200,508
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ISO
IEA
(PMID:25660456)
GO_REF:0000107
RGD
Ensembl
PMID:25660456 GO_REF:0000107 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Selenos selenoprotein S IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:15215856)
Ensembl
RGD
PMID:15215856, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Syvn1 synoviolin 1 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase ISO (PMID:24807418) RGD PMID:24807418 NCBI chr14:82,350,734...82,356,084
Ensembl chr14:82,350,734...82,356,078
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO (PMID:25660456) RGD PMID:25660456 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
G Vcp valosin-containing protein ISO
IBA
(MGI:MGI:5634892|PMID:12847084)
PMID:21873635
(PMID:15215856), (PMID:25660456)
RGD PMID:12847084, PMID:15215856, PMID:25660456, PMID:21873635 MGI:MGI:5634892, RGD:13792537 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
ubiquitin-dependent ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07001519.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:49,290,112...49,844,547 JBrowse link
G AABR07002848.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:86,873,253...86,888,958 JBrowse link
G Amfr autocrine motility factor receptor ISO (PMID:11724934), (PMID:16168377), (PMID:17872946) RGD PMID:11724934, PMID:16168377, PMID:17872946 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:82,393,619...82,400,537
Ensembl chr 9:82,393,672...82,400,530
JBrowse link
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor ISO
IBA
ISS
(PMID:23223569)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23223569, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:113,887,030...113,890,103
Ensembl chr 4:113,887,115...113,890,101
JBrowse link
G Bag6 BAG cochaperone 6 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:23129660), (PMID:24981174), (PMID:26565908)
UniProt
RGD
PMID:23129660, PMID:24981174, PMID:26565908, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Ccdc47 coiled-coil domain containing 47 ISO MGI:MGI:3722141 (MGI:MGI:5605216|PMID:25009997) RGD PMID:25009997 MGI:MGI:5605216 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Derl1 derlin 1 ISO
IBA
(PMID:15215856), (PMID:17872946), (PMID:18555783)
PMID:21873635
RGD PMID:15215856, PMID:17872946, PMID:18555783, PMID:21873635 RGD:13792537 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Derl2 derlin 2 ISO
IBA
(PMID:16449189)
PMID:21873635
RGD PMID:16449189, PMID:21873635 RGD:13792537 NCBI chr10:57,641,682...57,653,554
Ensembl chr10:57,644,207...57,653,359
JBrowse link
G Derl3 derlin 3 ISO
IBA
(PMID:22607976)
PMID:21873635
RGD PMID:22607976, PMID:21873635 RGD:13792537 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205
JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:29,445,510...29,463,739
Ensembl chr20:29,445,510...29,463,738
JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:243,108,443...243,151,933
Ensembl chr 2:243,018,975...243,151,933
JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 ISO
IBA
(PMID:15936278)
PMID:21873635
RGD PMID:15936278, PMID:21873635 RGD:13792537 NCBI chr 9:82,436,453...82,444,669
Ensembl chr 9:82,436,458...82,444,668
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 ISO
ISS
(PMID:18400946)
GO_REF:0000024
(MGI:MGI:5499714|PMID:22267725)
RGD
UniProt
PMID:18400946, PMID:22267725 GO_REF:0000024, MGI:MGI:5499714 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 ISO
ISS
(PMID:18400946)
(MGI:MGI:4943381|PMID:18653895), (MGI:MGI:4947480|PMID:21329881)
GO_REF:0000024
RGD
UniProt
PMID:18400946, PMID:18653895, PMID:21329881 GO_REF:0000024, MGI:MGI:4943381, MGI:MGI:4947480 NCBI chr 3:67,538,289...67,578,308
Ensembl chr 3:67,538,289...67,578,306
JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:28,466,892...28,501,013
Ensembl chr18:28,466,311...28,495,937
JBrowse link
G Ecpas Ecm29 proteasome adaptor and scaffold ISO (PMID:15496406) RGD PMID:15496406 NCBI chr 5:75,928,510...76,040,771
Ensembl chr 5:75,931,293...76,039,760
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 ISO (MGI:MGI:2178766|PMID:11375934) RGD PMID:11375934 MGI:MGI:2178766 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (PMID:17707796) RGD PMID:17707796 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 ISO (PMID:18502753) RGD PMID:18502753 NCBI chr14:115,314,890...115,352,871
Ensembl chr14:115,314,890...115,352,562
JBrowse link
G Erlin1 ER lipid raft associated 1 ISO (PMID:19240031) RGD PMID:19240031 NCBI chr 1:263,810,439...263,845,762
Ensembl chr 1:263,810,439...263,845,762
JBrowse link
G Erlin2 ER lipid raft associated 2 ISO (PMID:19240031) RGD PMID:19240031 NCBI chr16:69,179,005...69,195,452
Ensembl chr16:69,179,588...69,195,097
JBrowse link
G Faf2 Fas associated factor family member 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:24215460)
Ensembl
UniProt
RGD
PMID:24215460 GO_REF:0000024, GO_REF:0000107 NCBI chr17:10,485,650...10,527,886
Ensembl chr17:10,485,642...10,527,864
JBrowse link
G Fbxo17 F-box protein 17 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:86,903,762...86,919,238
Ensembl chr 1:86,914,137...86,919,236
JBrowse link
G Fbxo2 F-box protein 2 ISO
IBA
(MGI:MGI:3573989|PMID:15723043)
PMID:21873635
RGD PMID:15723043, PMID:21873635 MGI:MGI:3573989, RGD:13792537 NCBI chr 5:164,972,483...164,977,912
Ensembl chr 5:164,972,480...164,977,916
JBrowse link
G Fbxo44 F-box protein 44 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:164,962,921...164,972,273
Ensembl chr 5:164,963,433...164,971,903
JBrowse link
G Fbxo6 F-box protein 6 ISO
IBA
ISS
(MGI:MGI:2679753|PMID:12939278)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:12939278, PMID:21873635 GO_REF:0000024, MGI:MGI:2679753, RGD:13792537 NCBI chr 5:164,956,285...164,962,075
Ensembl chr 5:164,956,280...164,959,851
JBrowse link
G Foxred2 FAD-dependent oxidoreductase domain containing 2 ISO
IBA
(PMID:19706418)
PMID:21873635
RGD PMID:19706418, PMID:21873635 RGD:13792537 NCBI chr 7:119,172,189...119,186,670
Ensembl chr 7:119,170,181...119,185,238
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO (PMID:28827405) RGD PMID:28827405 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:18264092)
Ensembl
UniProt
RGD
PMID:18264092, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein ISO
IBA
(PMID:19269966)
PMID:21873635
RGD PMID:19269966, PMID:21873635 RGD:13792537 NCBI chr 6:94,835,845...94,849,784
Ensembl chr 6:94,835,845...94,849,784
JBrowse link
G LOC103694875 derlin-3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Man1a1 mannosidase, alpha, class 1A, member 1 ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:35,257,688...35,450,132
Ensembl chr20:35,257,985...35,450,513
JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 ISO
IBA
(MGI:MGI:3054306|PMID:15294975)
PMID:21873635
(PMID:18003979)
RGD PMID:15294975, PMID:18003979, PMID:21873635 MGI:MGI:3054306, RGD:13792537 NCBI chr 3:2,547,259...2,569,051
Ensembl chr 3:2,547,986...2,569,049
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712
JBrowse link
G Nccrp1 NCCRP1, F-box associated domain containing IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:85,558,420...85,559,652
NCBI chr 1:85,213,578...85,218,030
Ensembl chr 1:85,213,652...85,217,258
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:18264092), (PMID:18417469), (PMID:19346256)
UniProt
RGD
PMID:18264092, PMID:18417469, PMID:19346256, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:70,378,625...70,407,135
Ensembl chr 7:70,380,311...70,407,177
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914
JBrowse link
G RGD1562515 similar to RIKEN cDNA 4931417E11 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:101,392,229...101,393,329
Ensembl chr 4:101,392,229...101,393,329
JBrowse link
G Rnf103 ring finger protein 103 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:18675248)
Ensembl
RGD
PMID:18675248, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 4:99,398,479...99,415,193
Ensembl chr 4:99,398,494...99,421,164
JBrowse link
G Rnf121 ring finger protein 121 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:167,095,916...167,165,257
Ensembl chr 1:167,095,962...167,165,265
JBrowse link
G Rnf185 ring finger protein 185 ISO (PMID:24019521) RGD PMID:24019521 NCBI chr14:83,648,400...83,685,273
Ensembl chr14:83,648,402...83,685,273
JBrowse link
G Rnf5 ring finger protein 5 ISO UniProtKB:Q96GF1 (PMID:24019521) RGD PMID:24019521 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Sec61b SEC61 translocon subunit beta ISO (PMID:8945469) RGD PMID:8945469 NCBI chr 5:63,192,322...63,200,532
Ensembl chr 5:63,192,298...63,200,508
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Sel1l2 SEL1L2 adaptor subunit of ERAD E3 ligase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:134,281,809...134,406,560
Ensembl chr 3:134,281,807...134,462,653
JBrowse link
G Selenos selenoprotein S IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:15215856)
Ensembl
RGD
PMID:15215856, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO
IBA
ISS
(PMID:23129660)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23129660, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat containing beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:34,185,938...34,222,428
Ensembl chr 2:34,186,091...34,219,802
JBrowse link
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B ISO (PMID:22607976) RGD PMID:22607976 NCBI chr 8:123,303,910...123,370,729
Ensembl chr 8:123,293,057...123,371,257
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 ISO (PMID:23990462) RGD PMID:23990462 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Syvn1 synoviolin 1 ISO (PMID:12459480), (PMID:14593114), (PMID:17059562), (PMID:21245296), (PMID:22607976), (PMID:28827405) RGD PMID:12459480, PMID:14593114, PMID:17059562, PMID:21245296, PMID:22607976, PMID:28827405 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase ISO (PMID:24807418) RGD PMID:24807418 NCBI chr14:82,350,734...82,356,084
Ensembl chr14:82,350,734...82,356,078
JBrowse link
G Tmem67 transmembrane protein 67 IEA
ISO
GO_REF:0000107
(PMID:19815549)
Ensembl
RGD
PMID:19815549 GO_REF:0000107 NCBI chr 5:25,666,138...25,721,056
Ensembl chr 5:25,666,137...25,721,072
JBrowse link
G Tmub1 transmembrane and ubiquitin-like domain containing 1 ISO
IBA
(PMID:21343306)
PMID:21873635
RGD PMID:21343306, PMID:21873635 RGD:13792537 NCBI chr 4:7,257,752...7,260,318
Ensembl chr 4:7,257,752...7,260,317
JBrowse link
G Tmub2 transmembrane and ubiquitin-like domain containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:90,230,428...90,234,874
Ensembl chr10:90,230,441...90,234,873
JBrowse link
G Trim13 tripartite motif-containing 13 ISO
IBA
(PMID:17314412)
PMID:21873635
RGD PMID:17314412, PMID:21873635 RGD:13792537 NCBI chr15:41,897,191...41,936,545
Ensembl chr15:41,927,241...41,935,718
JBrowse link
G Trim25 tripartite motif-containing 25 ISO (PMID:24810856) RGD PMID:24810856 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 ISO
IBA
(MGI:MGI:2154298|PMID:11278356)
PMID:21873635
(PMID:22607976)
RGD PMID:11278356, PMID:22607976, PMID:21873635 MGI:MGI:2154298, RGD:13792537 NCBI chr20:11,700,089...11,721,823
Ensembl chr20:11,700,089...11,721,838
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 ISO
IBA
(MGI:MGI:5532755|PMID:24020373)
PMID:21873635
(PMID:21245296), (PMID:22607976)
RGD PMID:21245296, PMID:22607976, PMID:24020373, PMID:21873635 MGI:MGI:5532755, RGD:13792537 NCBI chr 5:48,274,387...48,292,699
Ensembl chr 5:48,274,477...48,290,658
JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 ISO
IBA
(PMID:24807418)
PMID:21873635
RGD PMID:24807418, PMID:21873635 RGD:13792537 NCBI chr 5:173,372,659...173,387,084
Ensembl chr 5:173,372,669...173,387,104
JBrowse link
G Ube4a ubiquitination factor E4A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:49,229,713...49,271,894
Ensembl chr 8:49,229,717...49,271,834
JBrowse link
G Ube4b ubiquitination factor E4B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069
JBrowse link
G Ubqln1 ubiquilin 1 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:19822669)
Ensembl
UniProt
RGD
PMID:19822669, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
G Ubqln2 ubiquilin 2 ISO
IBA
(PMID:24215460)
PMID:21873635
RGD PMID:24215460, PMID:21873635 RGD:13792537 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732
JBrowse link
G Ubxn4 UBX domain protein 4 ISO
ISS
(PMID:19822669)
GO_REF:0000024
RGD
UniProt
PMID:19822669 GO_REF:0000024 NCBI chr13:44,956,963...44,989,653
Ensembl chr13:44,957,014...44,990,535
JBrowse link
G Ubxn8 UBX domain protein 8 ISO (PMID:21949850) RGD PMID:21949850 NCBI chr16:62,251,243...62,272,838
Ensembl chr16:62,251,243...62,272,838
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
G Umod uromodulin ISO
IEA
(MGI:MGI:5916257|PMID:28437467)
GO_REF:0000107
RGD
Ensembl
PMID:28437467 GO_REF:0000107, MGI:MGI:5916257 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Usp19 ubiquitin specific peptidase 19 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:19465887)
Ensembl
UniProt
RGD
PMID:19465887, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 8:117,280,690...117,291,729
Ensembl chr 8:117,280,705...117,291,351
JBrowse link
G Vcp valosin-containing protein ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17872946), (PMID:22607976)
UniProt
RGD
PMID:17872946, PMID:22607976, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein ISO (MGI:MGI:5009360|PMID:20160352)
(PMID:20160352)
RGD PMID:20160352 MGI:MGI:5009360 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Yod1 YOD1 deubiquitinase ISO
IBA
ISS
(PMID:19818707)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19818707, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:47,441,296...47,443,013
Ensembl chr13:47,440,803...47,443,188
JBrowse link
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 ISO (PMID:21062743), (PMID:25092655) RGD PMID:21062743, PMID:25092655 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 ISO (PMID:15537790) RGD PMID:15537790 NCBI chr 3:151,232,741...151,258,559
Ensembl chr 3:151,232,751...151,258,580
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        response to organic substance 3865
          response to organonitrogen compound 1458
            ERAD pathway 102
              ER-associated misfolded protein catabolic process 13
              maintenance of unfolded protein involved in ERAD pathway 3
              negative regulation of ERAD pathway + 6
              positive regulation of ERAD pathway + 13
              protein localization to cytosolic proteasome complex involved in ERAD pathway 1
              regulation of ERAD pathway + 19
              retrograde protein transport, ER to cytosol + 27
              ubiquitin-dependent ERAD pathway + 80
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          protein metabolic process 6264
            protein catabolic process 996
              cellular protein catabolic process 827
                proteolysis involved in cellular protein catabolic process 770
                  proteasomal protein catabolic process 490
                    ERAD pathway 102
                      ER-associated misfolded protein catabolic process 13
                      maintenance of unfolded protein involved in ERAD pathway 3
                      negative regulation of ERAD pathway + 6
                      positive regulation of ERAD pathway + 13
                      protein localization to cytosolic proteasome complex involved in ERAD pathway 1
                      regulation of ERAD pathway + 19
                      retrograde protein transport, ER to cytosol + 27
                      ubiquitin-dependent ERAD pathway + 80
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.