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Term:Derlin-1 retrotranslocation complex
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Accession:GO:0036513 term browser browse the term
Definition:A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.
Comment:The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process.
Synonyms:exact_synonym: Derlin-1 complex;   Derlin-1 protein dislocation complex;   Derlin-1 retro-translocation complex;   Derlin-1 retrotranslocon;   ERAD protein dislocation complex

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Derlin-1 retrotranslocation complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
G Hm13 histocompatibility minor 13 JBrowse link 3 148,150,695 148,189,623 RGD:1624291
G Rnf139 ring finger protein 139 JBrowse link 7 98,770,840 98,782,025 RGD:1624291
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 6 115,572,683 115,616,904 RGD:1624291
G Selenos selenoprotein S JBrowse link 1 126,979,579 126,989,344 RGD:1624291
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      membrane protein complex 1210
        Derlin-1 retrotranslocation complex 8
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          organelle membrane 2679
            endoplasmic reticulum membrane 860
              Derlin-1 retrotranslocation complex 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.