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ONTOLOGY REPORT - ANNOTATIONS


Term:NIK/NF-kappaB signaling
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Accession:GO:0038061 term browser browse the term
Definition:The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
Synonyms:exact_synonym: NIK/NF-kappaB signal transduction
 narrow_synonym: p52-dependent NF-kappaB signaling
 broad_synonym: non-canonical NF-KB signaling;   noncanonical NF-kappaB signaling;   noncanonical nuclear factor kappaB (NF-kappaB) pathway
 related_synonym: NIK/NF-kappaB cascade


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NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:1624291
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:1624291
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:1600115
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:1600115
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:1624291
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:13792537
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:13792537
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:1624291
RGD:13792537
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1600115
activation of NF-kappaB-inducing kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1624291
G Card10 caspase recruitment domain family, member 10 JBrowse link 7 119,998,639 120,028,632 RGD:1624291
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:1624291
RGD:1600115
G Cops8 COP9 signalosome subunit 8 JBrowse link 9 97,772,224 97,782,055 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1624291
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:1624291
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tnfsf15 TNF superfamily member 15 JBrowse link 5 79,553,935 79,569,974 RGD:1624291
RGD:1600115
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291
G Traf4 Tnf receptor associated factor 4 JBrowse link 10 65,418,688 65,424,802 RGD:1600115
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Zfp91 zinc finger protein 91 JBrowse link 1 229,602,499 229,640,906 RGD:1624291
negative regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg3 adhesion G protein-coupled receptor G3 JBrowse link 19 10,392,001 10,422,606 RGD:1624291
G Adipor1 adiponectin receptor 1 JBrowse link 13 51,240,470 51,260,233 RGD:1624291
G C1qtnf3 C1q and TNF related 3 JBrowse link 2 60,920,160 60,942,586 RGD:1624291
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:13792556
G Ccn3 cellular communication network factor 3 JBrowse link 7 94,375,134 94,382,154 RGD:1600115
RGD:1624291
G Cpne1 copine 1 JBrowse link 3
3
151,617,733
152,150,143
151,625,448
152,192,936
RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1600115
RGD:1624291
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:1624291
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:1600115
RGD:1624291
G Litaf lipopolysaccharide-induced TNF factor JBrowse link 10 4,753,546 4,763,272 RGD:1624291
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 1 162,369,801 162,376,024 RGD:11040458
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 10 11,809,531 11,844,184 RGD:1624291
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:13792537
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1600115
RGD:1624291
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:1600115
RGD:1624291
G Rassf2 Ras association domain family member 2 JBrowse link 3 124,574,088 124,610,267 RGD:1624291
RGD:1600115
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:1624291
G Tspan6 tetraspanin 6 JBrowse link X 104,719,930 104,729,606 RGD:1624291
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats JBrowse link 8 65,686,586 65,774,940 RGD:1624291
RGD:13792537
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
positive regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07009373.1 RGD:13792537
G AABR07019870.1 RGD:13792537
G AABR07025074.1 RGD:13792537
G AABR07029613.1 RGD:13792537
G AABR07035218.1 RGD:13792537
G AABR07054355.1 RGD:13792537
G AABR07054358.1 RGD:13792537
G AABR07060165.1 RGD:13792537
G AABR07060287.1 RGD:13792537
G AABR07067274.1 RGD:13792537
G AC094217.2 RGD:13792537
G AC108595.1 RGD:13792537
G Actn4 actinin alpha 4 JBrowse link 1 87,078,012 87,147,347 RGD:1624291
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Ago1 argonaute RISC component 1 JBrowse link 5 144,444,390 144,479,430 RGD:1624291
G Ago3 argonaute RISC catalytic component 3 JBrowse link 5 144,355,792 144,436,509 RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G C1qtnf4 C1q and TNF related 4 JBrowse link 3 79,713,580 79,718,018 RGD:1624291
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:1624291
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:1624291
RGD:13792537
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:1624291
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:10059423
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Eda ectodysplasin-A JBrowse link X 69,730,123 70,222,693 RGD:1624291
RGD:13792537
G Edar ectodysplasin-A receptor JBrowse link 20 28,179,132 28,263,092 RGD:1624291
G Edaradd EDAR-associated death domain JBrowse link 17 90,802,280 90,843,476 RGD:14398762
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:13601996
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1624291
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1624291
RGD:1600115
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1624291
G Glrx glutaredoxin JBrowse link 2 2,606,032 2,615,944 RGD:9686063
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 JBrowse link 19 59,984,234 59,985,494 RGD:13792537
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:13792537
G Hmgb1-ps3 high mobility group box 1, pseudogene 3 JBrowse link 7 132,982,959 132,984,167 RGD:13792537
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:1600115
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Lims1 LIM zinc finger domain containing 1 JBrowse link 20 27,895,981 28,004,767 RGD:1624291
G LOC100911637 high mobility group protein B1-like JBrowse link 3 149,741,055 149,741,953 RGD:13792537
G LOC108349189 high mobility group protein B1 pseudogene JBrowse link X 115,351,012 115,351,755 RGD:13792537
G LOC108350839 high mobility group protein B1-like JBrowse link 4 92,431,517 92,432,354 RGD:13792537
G Lrrc19 leucine rich repeat containing 19 JBrowse link 5 113,614,164 113,626,834 RGD:1624291
RGD:13792537
G Mmp8 matrix metallopeptidase 8 JBrowse link 8 5,768,808 5,777,741 RGD:1600115
RGD:1624291
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:1624291
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:1600115
RGD:1624291
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:1624291
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:1600115
RGD:1624291
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:1600115
RGD:1624291
G Ptp4a3 protein tyrosine phosphatase 4A3 JBrowse link 7 114,969,699 115,002,902 RGD:1624291
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:1624291
RGD:1600115
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G RGD1563668 similar to High mobility group protein 1 (HMG-1) JBrowse link 10 40,994,237 40,994,990 RGD:13792537
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
G Rtkn2 rhotekin 2 JBrowse link 20 21,919,486 22,004,279 RGD:1624291
G Sash1 SAM and SH3 domain containing 1 JBrowse link 1 2,782,905 2,950,749 RGD:1624291
RGD:13792537
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:10042970
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1600115
RGD:1624291
G Tcim transcriptional and immune response regulator JBrowse link 16 72,401,526 72,403,180 RGD:1624291
G Terf2ip TERF2 interacting protein JBrowse link 19 44,231,317 44,238,406 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tnfsf14 TNF superfamily member 14 JBrowse link 9 9,761,363 9,765,461 RGD:1624291
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Trim44 tripartite motif-containing 44 JBrowse link 3 91,968,781 92,242,138 RGD:1600115
RGD:1624291
G Trip6 thyroid hormone receptor interactor 6 JBrowse link 12 22,451,596 22,456,003 RGD:1624291
RGD:13792537
regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akip1 A-kinase interacting protein 1 JBrowse link 1 174,330,628 174,339,494 RGD:1600115
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:1624291
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:1624291
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
G Eda ectodysplasin-A JBrowse link X 69,730,123 70,222,693 RGD:1624291
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Lime1 Lck interacting transmembrane adaptor 1 JBrowse link 3 176,881,881 176,888,230 RGD:1624291
RGD:13792537
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1624291
RGD:1600115
G Prdx1 peroxiredoxin 1 JBrowse link 5 135,536,413 135,551,986 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Rassf2 Ras association domain family member 2 JBrowse link 3 124,574,088 124,610,267 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:1624291
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:1624291
G Trim6 tripartite motif containing 6 JBrowse link 1 169,410,084 169,423,305 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    signaling 7531
      signal transduction 6946
        intracellular signal transduction 2594
          NIK/NF-kappaB signaling 139
            activation of NF-kappaB-inducing kinase activity 16
            negative regulation of NIK/NF-kappaB signaling 23
            positive regulation of NIK/NF-kappaB signaling + 98
            regulation of NIK/NF-kappaB signaling + 130
Path 2
Term Annotations click to browse term
  biological_process 19678
    biological regulation 13599
      regulation of biological process 12921
        regulation of cellular process 12405
          signal transduction 6946
            intracellular signal transduction 2594
              NIK/NF-kappaB signaling 139
                activation of NF-kappaB-inducing kinase activity 16
                negative regulation of NIK/NF-kappaB signaling 23
                positive regulation of NIK/NF-kappaB signaling + 98
                regulation of NIK/NF-kappaB signaling + 130
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.