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ONTOLOGY REPORT - ANNOTATIONS


Term:nodal signaling pathway
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Accession:GO:0038092 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: nodal signaling;   nodal signalling pathway


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nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B ISO UniProtKB:P43021 (PMID:11389842) RGD PMID:11389842 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Acvr1c activin A receptor type 1C ISO
IEA
(PMID:15150278)
GO_REF:0000107
RGD
Ensembl
PMID:15150278 GO_REF:0000107 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 ISO
IBA
(MGI:MGI:5318034|PMID:12052855)
PMID:21873635
RGD PMID:12052855, PMID:21873635 MGI:MGI:5318034, RGD:13792537 NCBI chr 9:41,045,352...41,051,979
Ensembl chr 9:41,045,363...41,052,024
JBrowse link
G Nodal nodal growth differentiation factor ISO (MGI:MGI:5318034|PMID:12052855) RGD PMID:12052855 MGI:MGI:5318034 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Smad2 SMAD family member 2 ISO (PMID:15150278) RGD PMID:15150278 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:15150278) RGD PMID:15150278 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 ISO
IBA
UniProtKB:P43021 (MGI:MGI:5318034|PMID:12052855), (MGI:MGI:5447629|PMID:11389842)
PMID:21873635
RGD PMID:11389842, PMID:12052855, PMID:21873635 MGI:MGI:5318034, MGI:MGI:5447629, RGD:13792537 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 ISO MGI:MGI:1915299 (MGI:MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:MGI:4430444 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 ISO MGI:MGI:1194497 (MGI:MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:MGI:4430444 NCBI chr 3:152,906,961...152,924,380
Ensembl chr 3:152,909,189...152,924,377
JBrowse link
negative regulation of nodal receptor complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lefty1 left right determination factor 1 ISO (MGI:MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:MGI:3042530 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
negative regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO
IBA
(MGI:MGI:3809364|PMID:18716284), (MGI:MGI:5437437|PMID:17197390)
PMID:21873635
RGD PMID:17197390, PMID:18716284, PMID:21873635 MGI:MGI:3809364, MGI:MGI:5437437, RGD:13792537 NCBI chr 1:56,159,435...56,169,443
Ensembl chr 1:56,159,426...56,168,351
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
G Lefty1 left right determination factor 1 ISO (MGI:MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:MGI:3042530 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 ISO (MGI:MGI:3054669|PMID:15475956) RGD PMID:15475956 MGI:MGI:3054669 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Nodal nodal growth differentiation factor ISO (MGI:MGI:5315339|PMID:17507406) RGD PMID:17507406 MGI:MGI:5315339 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO (PMID:17239842) RGD PMID:17239842 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Zic2 Zic family member 2 ISO MGI:MGI:1862004 (MGI:MGI:5584215|PMID:24585447) RGD PMID:24585447 MGI:MGI:5584215 NCBI chr15:108,908,366...108,913,812
Ensembl chr15:108,908,607...108,912,737
JBrowse link
regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact1 dishevelled-binding antagonist of beta-catenin 1 NOT ISO (PMID:17197390)
(MGI:MGI:5437437|PMID:17197390)
RGD PMID:17197390 MGI:MGI:5437437 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 ISO (MGI:MGI:5487845|PMID:23473982) RGD PMID:23473982 MGI:MGI:5487845 NCBI chr 1:243,477,403...243,582,629
Ensembl chr 1:243,477,493...243,582,629
JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          enzyme linked receptor protein signaling pathway 969
            transmembrane receptor protein serine/threonine kinase signaling pathway 387
              activin receptor signaling pathway 47
                nodal signaling pathway 17
                  negative regulation of nodal signaling pathway + 4
                  nodal receptor complex assembly + 1
                  nodal signaling pathway involved in determination of left/right asymmetry + 6
                  regulation of nodal signaling pathway + 8
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            cell surface receptor signaling pathway 2761
              enzyme linked receptor protein signaling pathway 969
                transmembrane receptor protein serine/threonine kinase signaling pathway 387
                  activin receptor signaling pathway 47
                    nodal signaling pathway 17
                      negative regulation of nodal signaling pathway + 4
                      nodal receptor complex assembly + 1
                      nodal signaling pathway involved in determination of left/right asymmetry + 6
                      regulation of nodal signaling pathway + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.