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ONTOLOGY REPORT - ANNOTATIONS


Term:Kit signaling pathway
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Accession:GO:0038109 term browser browse the term
Definition:A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
Synonyms:exact_synonym: Kit signalling pathway;   SCF signaling pathway;   stem cell factor receptor signaling pathway;   stem cell factor signaling pathway


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Kit signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fer FER tyrosine kinase IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:2385502|PMID:12192036)
Ensembl
UniProt
RGD
PMID:12192036 GO_REF:0000024, GO_REF:0000107, MGI:MGI:2385502 NCBI chr 9:111,557,804...111,868,583
Ensembl chr 9:111,597,037...111,862,670
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase ISO
IBA
(PMID:17662946)
PMID:21873635
RGD PMID:17662946, PMID:21873635 RGD:13792537 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
negative regulation of Kit signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rabgef1 RAB guanine nucleotide exchange factor 1 ISO MGI:MGI:3051384 (MGI:MGI:3620385|PMID:16533754) RGD PMID:16533754 MGI:MGI:3620385 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959
JBrowse link
G Sh2b3 SH2B adaptor protein 3 ISO
IEA
GO:1990782 (MGI:MGI:3041996|PMID:14612394)
GO_REF:0000107
RGD
Ensembl
PMID:14612394 GO_REF:0000107, MGI:MGI:3041996 NCBI chr12:40,261,990...40,265,757
Ensembl chr12:40,244,081...40,265,757
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            Kit signaling pathway 4
              negative regulation of Kit signaling pathway 2
              positive regulation of Kit signaling pathway 0
              regulation of Kit signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            cell surface receptor signaling pathway 2761
              enzyme linked receptor protein signaling pathway 969
                transmembrane receptor protein tyrosine kinase signaling pathway 606
                  Kit signaling pathway 4
                    negative regulation of Kit signaling pathway 2
                    positive regulation of Kit signaling pathway 0
                    regulation of Kit signaling pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.