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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-2-mediated signaling pathway
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Accession:GO:0038110 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-2-mediated signaling pathway;   interleukin-2-mediated signalling pathway


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interleukin-2-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2ra interleukin 2 receptor subunit alpha IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il2rb interleukin 2 receptor subunit beta ISO
IEA
ISS
(PMID:31040184)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31040184 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Jak1 Janus kinase 1 ISO (PMID:11909529) RGD PMID:11909529 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(PMID:11909529)
(MGI:MGI:3691503|PMID:11909529)
GO_REF:0000024
RGD
UniProt
PMID:11909529 GO_REF:0000024, MGI:MGI:3691503 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            interleukin-2-mediated signaling pathway 4
              negative regulation of interleukin-2-mediated signaling pathway 1
              positive regulation of interleukin-2-mediated signaling pathway 0
              regulation of interleukin-2-mediated signaling pathway + 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        response to organic substance 3865
          cellular response to organic substance 2845
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                interleukin-2-mediated signaling pathway 4
                  negative regulation of interleukin-2-mediated signaling pathway 1
                  positive regulation of interleukin-2-mediated signaling pathway 0
                  regulation of interleukin-2-mediated signaling pathway + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.