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ONTOLOGY REPORT - ANNOTATIONS


Term:macrophage colony-stimulating factor signaling pathway
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Accession:GO:0038145 term browser browse the term
Definition:A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: M-CSF signaling pathway;   macrophage colony-stimulating factor signalling pathway


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macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1 colony stimulating factor 1 ISO (MGI:MGI:3836228|PMID:19017797) RGD PMID:19017797 MGI:MGI:3836228 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf1r colony stimulating factor 1 receptor IEA
ISO
GO_REF:0000107
(MGI:MGI:3831067|PMID:19100238), (MGI:MGI:3836228|PMID:19017797)
Ensembl
RGD
PMID:19017797, PMID:19100238 GO_REF:0000107, MGI:MGI:3831067, MGI:MGI:3836228 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Dok1 docking protein 1 ISO PR:P09581 (MGI:MGI:1350556|PMID:10585470) RGD PMID:10585470 MGI:MGI:1350556 NCBI chr 4:113,864,211...113,866,695
Ensembl chr 4:113,864,215...113,866,674
JBrowse link
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:3629372|PMID:16705167)
GO_REF:0000024
RGD
UniProt
PMID:16705167 GO_REF:0000024, MGI:MGI:3629372 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Stap1 signal transducing adaptor family member 1 ISO (MGI:MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:MGI:3831067 NCBI chr14:23,575,400...23,604,984
Ensembl chr14:23,576,085...23,604,834
JBrowse link
positive regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1 colony stimulating factor 1 ISO
IEA
(PMID:19100238)
GO_REF:0000107
RGD
Ensembl
PMID:19100238 GO_REF:0000107 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        cell surface receptor signaling pathway 2761
          cytokine-mediated signaling pathway 406
            macrophage colony-stimulating factor signaling pathway 5
              negative regulation of macrophage colony-stimulating factor signaling pathway 2
              positive regulation of macrophage colony-stimulating factor signaling pathway 1
              regulation of macrophage colony-stimulating factor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to chemical 6343
        response to organic substance 3865
          cellular response to organic substance 2845
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                macrophage colony-stimulating factor signaling pathway 5
                  negative regulation of macrophage colony-stimulating factor signaling pathway 2
                  positive regulation of macrophage colony-stimulating factor signaling pathway 1
                  regulation of macrophage colony-stimulating factor signaling pathway + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.