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ONTOLOGY REPORT - ANNOTATIONS


Term:angiotensin-activated signaling pathway
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Accession:GO:0038166 term browser browse the term
Definition:The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: angiotensin II-mediated signaling pathway;   angiotensin receptor signaling pathway
 related_synonym: angiotensin-mediated signaling pathway


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angiotensin-activated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISS
ISO
GO_REF:0000024
(PMID:24296617)
BHF-UCL
RGD
PMID:24296617 GO_REF:0000024 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO
IMP
(PMID:1567413)
PMID:21769867
RGD PMID:1567413, PMID:21769867 RGD:5688337 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr1b angiotensin II receptor, type 1b IMP PMID:21769867 RGD
BHF-UCL
PMID:7862653, PMID:21769867 RGD:10047113, RGD:5688337 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Agtrap angiotensin II receptor-associated protein IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:164,888,069...164,898,387
Ensembl chr 5:164,886,813...164,898,420
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 ISO
ISS
(PMID:20584908)
GO_REF:0000024
RGD
UniProt
PMID:20584908 GO_REF:0000024 NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO
IEA
(PMID:20584908)
GO_REF:0000107
RGD
Ensembl
PMID:20584908 GO_REF:0000107 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Car2 carbonic anhydrase 2 ISO
ISS
(PMID:15990874)
GO_REF:0000024
RGD
UniProt
PMID:15990874 GO_REF:0000024 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Dear dual endothelin 1, angiotensin II receptor IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:184,243,976...184,247,228
Ensembl chr 2:184,243,976...184,247,228
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
JBrowse link
G Mas1l MAS1 proto-oncogene like, G protein-coupled receptor IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:48,068,389...48,206,902
Ensembl chr 1:48,069,194...48,070,536
JBrowse link
G Slc26a6 solute carrier family 26 member 6 ISO (PMID:15990874) RGD PMID:15990874 NCBI chr 8:117,648,792...117,659,376
Ensembl chr 8:117,648,745...117,659,804
JBrowse link
angiotensin-activated signaling pathway involved in heart process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IEA
ISO
GO_REF:0000107
UniProtKB:P09470 (MGI:5607357|PMID:25017399)
Ensembl
RGD
PMID:25017399 GO_REF:0000107, MGI:5607357 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO UniProtKB:P09470|UniProtKB:P49817 (MGI:5607357|PMID:25017399) RGD PMID:25017399 MGI:5607357 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
phospholipase C-activating angiotensin-activated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 ISO (PMID:25433700) RGD PMID:25433700 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO (PMID:1378723) RGD PMID:1378723 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr1b angiotensin II receptor, type 1b IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
JBrowse link
regulation of angiotensin-activated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA
ISO
GO_REF:0000107
(PMID:28679962)
Ensembl
RGD
PMID:28679962 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 ISO (MGI:6158813|PMID:28679962) RGD PMID:28679962 MGI:6158813 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          angiotensin-activated signaling pathway 17
            angiotensin-activated signaling pathway involved in heart process + 2
            negative regulation of angiotensin-activated signaling pathway 0
            phospholipase C-activating angiotensin-activated signaling pathway + 3
            positive regulation of angiotensin-activated signaling pathway 0
            regulation of angiotensin-activated signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to chemical 6337
        response to nitrogen compound 1552
          response to organonitrogen compound 1456
            cellular response to organonitrogen compound 848
              cellular response to peptide 464
                cellular response to peptide hormone stimulus 389
                  cellular response to angiotensin 37
                    angiotensin-activated signaling pathway 17
                      angiotensin-activated signaling pathway involved in heart process + 2
                      negative regulation of angiotensin-activated signaling pathway 0
                      phospholipase C-activating angiotensin-activated signaling pathway + 3
                      positive regulation of angiotensin-activated signaling pathway 0
                      regulation of angiotensin-activated signaling pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.