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ONTOLOGY REPORT - ANNOTATIONS


Term:angiotensin-activated signaling pathway
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Accession:GO:0038166 term browser browse the term
Definition:The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: angiotensin II-mediated signaling pathway;   angiotensin receptor signaling pathway
 related_synonym: angiotensin-mediated signaling pathway


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angiotensin-activated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1600115
RGD:1624291
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
RGD:5688337
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:10047113
RGD:5688337
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1600115
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:1600115
G Ahcyl1 adenosylhomocysteinase-like 1 JBrowse link 2 210,438,884 210,474,350 RGD:1624291
RGD:1600115
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:1624291
G Car2 carbonic anhydrase 2 JBrowse link 2 88,097,740 88,112,868 RGD:1624291
RGD:1600115
G Dear dual endothelin 1, angiotensin II receptor JBrowse link 2 184,243,976 184,247,228 RGD:1600115
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1600115
G Mas1l MAS1 proto-oncogene like, G protein-coupled receptor JBrowse link 1 48,068,389 48,206,902 RGD:1600115
G Slc26a6 solute carrier family 26 member 6 JBrowse link 8 117,648,792 117,659,376 RGD:1624291
angiotensin-activated signaling pathway involved in heart process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1624291
RGD:1600115
phospholipase C-activating angiotensin-activated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn2 actinin alpha 2 JBrowse link 17 66,304,530 66,397,647 RGD:1624291
RGD:1600115
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
RGD:1600115
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1600115
regulation of angiotensin-activated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1600115
RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    signaling 7108
      signal transduction 6597
        G protein-coupled receptor signaling pathway 2395
          angiotensin-activated signaling pathway 17
            angiotensin-activated signaling pathway involved in heart process + 2
            negative regulation of angiotensin-activated signaling pathway 0
            phospholipase C-activating angiotensin-activated signaling pathway + 3
            positive regulation of angiotensin-activated signaling pathway 0
            regulation of angiotensin-activated signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 18166
    response to stimulus 9928
      response to chemical 6195
        response to nitrogen compound 1512
          response to organonitrogen compound 1420
            cellular response to organonitrogen compound 832
              cellular response to peptide 446
                cellular response to peptide hormone stimulus 371
                  cellular response to angiotensin 35
                    angiotensin-activated signaling pathway 17
                      angiotensin-activated signaling pathway involved in heart process + 2
                      negative regulation of angiotensin-activated signaling pathway 0
                      phospholipase C-activating angiotensin-activated signaling pathway + 3
                      positive regulation of angiotensin-activated signaling pathway 0
                      regulation of angiotensin-activated signaling pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.