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ONTOLOGY REPORT - ANNOTATIONS


Term:complement component C5a signaling pathway
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Accession:GO:0038178 term browser browse the term
Definition:A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.
Synonyms:exact_synonym: complement component C5a-induced signaling pathway


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complement component C5a signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C5ar1 complement C5a receptor 1 ISO (PMID:10571060) RGD PMID:10571060 NCBI chr 1:78,186,777...78,195,132
Ensembl chr 1:78,186,776...78,195,328
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G C5ar2 complement component 5a receptor 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:78,165,155...78,183,426
Ensembl chr 1:78,166,810...78,180,216
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          complement component C5a signaling pathway 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of immune system process 1480
          regulation of immune response 837
            positive regulation of immune response 654
              activation of immune response 418
                immune response-activating signal transduction 319
                  immune response-activating cell surface receptor signaling pathway 318
                    complement receptor mediated signaling pathway 13
                      complement component C5a signaling pathway 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.