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ONTOLOGY REPORT - ANNOTATIONS


Term:cytoplasmic pattern recognition receptor signaling pathway in response to virus
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Accession:GO:0039528 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
Comment:This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
Synonyms:exact_synonym: cytoplasmic pattern recognition receptor signalling pathway in response to virus;   virus-induced cytoplasmic pattern recognition receptor signaling pathway
 narrow_synonym: RIG-I-like receptor (RLR) signaling pathway;   RIG-I/MDA5 signaling pathway;   RIG-like helicase signaling pathway;   RIG-like receptor signaling pathway;   RLH signaling pathway;   RLR signaling pathway;   cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway


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MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:1624291
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Tkfc triokinase and FMN cyclase JBrowse link 1 226,642,901 226,657,698 RGD:1624291
RGD:1600115
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Gpatch3 G patch domain containing 3 JBrowse link 5 151,796,456 151,806,007 RGD:1624291
RGD:13792537
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
RGD:1600115
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:1600115
RGD:1624291
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
G Sec14l1 SEC14-like lipid binding 1 JBrowse link 10 106,065,712 106,112,859 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:1624291
RGD:1600115
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tspan6 tetraspanin 6 JBrowse link X 104,719,930 104,729,606 RGD:1624291
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G Pum1 pumilio RNA-binding family member 1 JBrowse link 5 148,781,239 148,911,776 RGD:1624291
G Pum2 pumilio RNA-binding family member 2 JBrowse link 6 33,786,184 33,865,693 RGD:1624291
G Trim15 tripartite motif containing 15 JBrowse link 20 2,194,293 2,203,636 RGD:1624291
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:1600115
RGD:1624291
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 JBrowse link 4 66,012,111 66,062,160 RGD:1624291
G Zcchc3 zinc finger CCHC-type containing 3 JBrowse link 3 147,877,321 147,881,434 RGD:1624291
regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clpb caseinolytic mitochondrial matrix peptidase chaperone subunit B JBrowse link 1 166,739,372 166,866,095 RGD:1624291
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:1624291
G Lsm14a LSM14A mRNA processing body assembly factor JBrowse link 1 90,200,866 90,246,292 RGD:1624291
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:1624291
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:1624291
G Rnf135 ring finger protein 135 JBrowse link 10 67,531,989 67,551,237 RGD:1600115
RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8952
      positive regulation of multicellular organismal process 2058
        positive regulation of cytokine production 500
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
            MDA-5 signaling pathway + 8
            RIG-I signaling pathway + 26
            negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 11
            regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 21
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      organic substance metabolic process 11494
        macromolecule metabolic process 9943
          gene expression 6164
            cytokine production 842
              regulation of cytokine production 759
                positive regulation of cytokine production 500
                  cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
                    MDA-5 signaling pathway + 8
                    RIG-I signaling pathway + 26
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 11
                    regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway + 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.