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ONTOLOGY REPORT - ANNOTATIONS


Term:RIG-I signaling pathway
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Accession:GO:0039529 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
Comment:The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect.
Synonyms:exact_synonym: DDX58 signaling pathway;   RIG-I signalling pathway;   retinoic acid inducible gene I signaling pathway


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RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clpb caseinolytic mitochondrial matrix peptidase chaperone subunit B ISO
IEA
(PMID:31522117)
GO_REF:0000107
RGD
Ensembl
PMID:31522117 GO_REF:0000107 NCBI chr 1:166,739,372...166,866,095
Ensembl chr 1:166,739,532...166,866,107
JBrowse link
G Ddx58 DEXD/H-box helicase 58 ISO (PMID:19211564), (PMID:28469175) RGD PMID:19211564, PMID:28469175 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor ISO MGI:MGI:2442858|MGI:MGI:2444773 (MGI:MGI:5432265|PMID:22745163) RGD PMID:22745163 MGI:MGI:5432265 NCBI chr 1:90,200,866...90,246,292
Ensembl chr 1:90,200,876...90,246,297
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO MGI:MGI:1914320 (MGI:MGI:5432265|PMID:22745163) RGD PMID:22745163 MGI:MGI:5432265 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Phb prohibitin ISO (PMID:31522117) RGD PMID:31522117 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phb2 prohibitin 2 ISO (PMID:31522117) RGD PMID:31522117 NCBI chr 4:157,230,769...157,235,375
Ensembl chr 4:157,230,769...157,235,367
JBrowse link
G Rnf135 ring finger protein 135 ISS
ISO
GO_REF:0000024
UniProtKB:Q8IUD6 (MGI:MGI:6152590|PMID:21147464), (MGI:MGI:6377978|PMID:28469175)
(PMID:23950712), (PMID:28469175), (PMID:31006531)
UniProt
RGD
PMID:21147464, PMID:23950712, PMID:28469175, PMID:31006531 GO_REF:0000024, MGI:MGI:6152590, MGI:MGI:6377978 NCBI chr10:67,531,989...67,551,237 JBrowse link
G Trim25 tripartite motif-containing 25 NOT ISO (PMID:31006531) RGD PMID:31006531 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145
JBrowse link
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein ISO
ISS
(PMID:19164550)
GO_REF:0000024
RGD
UniProt
PMID:19164550 GO_REF:0000024 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (MGI:MGI:3836702|PMID:17475874)
(PMID:18411269), (PMID:21187438)
RGD PMID:17475874, PMID:18411269, PMID:21187438 MGI:MGI:3836702 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Gpatch3 G patch domain containing 3 ISO
IBA
(PMID:28414768)
PMID:21873635
RGD PMID:28414768, PMID:21873635 RGD:13792537 NCBI chr 5:151,796,456...151,806,007
Ensembl chr 5:151,796,814...151,805,976
JBrowse link
G Nlrx1 NLR family member X1 ISO
IEA
MGI:MGI:5141085 (MGI:MGI:5050761|PMID:21703540)
GO_REF:0000107
RGD
Ensembl
PMID:21703540 GO_REF:0000107, MGI:MGI:5050761 NCBI chr 8:48,583,559...48,600,203
Ensembl chr 8:48,584,071...48,597,867
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26471729)
Ensembl
UniProt
RGD
PMID:26471729 GO_REF:0000024, GO_REF:0000107 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) RGD PMID:17460044, PMID:26471729 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Sec14l1 SEC14-like lipid binding 1 ISO (PMID:23843640) RGD PMID:23843640 NCBI chr10:106,065,712...106,112,859
Ensembl chr10:106,065,712...106,112,857
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO
ISS
(PMID:26471729)
GO_REF:0000024
RGD
UniProt
PMID:26471729 GO_REF:0000024 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07025140.1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr16:29,834,086...29,936,307 JBrowse link
G Ankrd17 ankyrin repeat domain 17 ISO (PMID:22328336) RGD PMID:22328336 NCBI chr14:19,291,025...19,431,521
Ensembl chr14:19,318,565...19,431,515
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (MGI:MGI:4421606|PMID:20080593) RGD PMID:20080593 MGI:MGI:4421606 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like ISO (PMID:20368735) RGD PMID:20368735 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link
G Pum1 pumilio RNA-binding family member 1 ISO (PMID:25340845) RGD PMID:25340845 NCBI chr 5:148,781,239...148,911,776
Ensembl chr 5:148,781,222...148,911,803
JBrowse link
G Pum2 pumilio RNA-binding family member 2 ISO (PMID:25340845) RGD PMID:25340845 NCBI chr 6:33,786,184...33,865,693
Ensembl chr 6:33,786,197...33,865,687
JBrowse link
G Trim15 tripartite motif containing 15 ISO (PMID:23077300) RGD PMID:23077300 NCBI chr20:2,194,293...2,203,636
Ensembl chr20:2,194,709...2,201,668
JBrowse link
G Usp15 ubiquitin specific peptidase 15 IEA
ISO
GO_REF:0000107
(PMID:24399297)
Ensembl
RGD
PMID:24399297 GO_REF:0000107 NCBI chr 7:66,595,707...66,687,707
Ensembl chr 7:66,595,742...66,687,278
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO (PMID:21102435) RGD PMID:21102435 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
G Zcchc3 zinc finger CCHC-type containing 3 ISO (PMID:30193849) RGD PMID:30193849 NCBI chr 3:147,877,321...147,881,434
Ensembl chr 3:147,878,936...147,880,138
JBrowse link
regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:27824081) RGD PMID:27824081 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      immune effector process 877
        defense response to virus 243
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
            RIG-I signaling pathway 26
              negative regulation of RIG-I signaling pathway 8
              positive regulation of RIG-I signaling pathway 10
              regulation of RIG-I signaling pathway + 18
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to external stimulus 3204
        response to external biotic stimulus 1712
          response to other organism 1708
            response to virus 319
              defense response to virus 243
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
                  RIG-I signaling pathway 26
                    negative regulation of RIG-I signaling pathway 8
                    positive regulation of RIG-I signaling pathway 10
                    regulation of RIG-I signaling pathway + 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.