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ONTOLOGY REPORT - ANNOTATIONS


Term:MDA-5 signaling pathway
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Accession:GO:0039530 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
Synonyms:exact_synonym: IFIH1 signaling pathway;   MDA-5 signalling pathway;   melanoma differentiation-associated gene 5 signaling pathway
 narrow_synonym: MDA5 signaling pathway


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MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:1624291
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Tkfc triokinase and FMN cyclase JBrowse link 1 226,642,901 226,657,698 RGD:1624291
RGD:1600115
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8952
      positive regulation of multicellular organismal process 2058
        positive regulation of cytokine production 500
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
            MDA-5 signaling pathway 8
              negative regulation of MDA-5 signaling pathway 4
              positive regulation of MDA-5 signaling pathway 4
              regulation of MDA-5 signaling pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      organic substance metabolic process 11494
        macromolecule metabolic process 9943
          gene expression 6164
            cytokine production 842
              regulation of cytokine production 759
                positive regulation of cytokine production 500
                  cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
                    MDA-5 signaling pathway 8
                      negative regulation of MDA-5 signaling pathway 4
                      positive regulation of MDA-5 signaling pathway 4
                      regulation of MDA-5 signaling pathway + 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.