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ONTOLOGY REPORT - ANNOTATIONS


Term:MDA-5 signaling pathway
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Accession:GO:0039530 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
Synonyms:exact_synonym: IFIH1 signaling pathway;   MDA-5 signalling pathway;   melanoma differentiation-associated gene 5 signaling pathway
 narrow_synonym: MDA5 signaling pathway


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MDA-5 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 ISO (PMID:17600090) RGD PMID:17600090 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein ISO
ISS
(PMID:19164550)
GO_REF:0000024
RGD
UniProt
PMID:19164550 GO_REF:0000024 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (PMID:21187438) RGD PMID:21187438 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Riok3 RIO kinase 3 ISO (PMID:25865883) RGD PMID:25865883 NCBI chr18:3,565,166...3,590,739
Ensembl chr18:3,565,166...3,590,739
JBrowse link
G Tkfc triokinase and FMN cyclase ISO
ISS
(PMID:17600090)
GO_REF:0000024
RGD
UniProt
PMID:17600090 GO_REF:0000024 NCBI chr 1:226,642,901...226,657,698
Ensembl chr 1:226,644,200...226,657,408
JBrowse link
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07025140.1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr16:29,834,086...29,936,307 JBrowse link
G Ankrd17 ankyrin repeat domain 17 ISO (PMID:22328336) RGD PMID:22328336 NCBI chr14:19,291,025...19,431,521
Ensembl chr14:19,318,565...19,431,515
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (MGI:MGI:4421606|PMID:20080593) RGD PMID:20080593 MGI:MGI:4421606 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like ISO (PMID:20368735) RGD PMID:20368735 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    multicellular organismal process 9055
      positive regulation of multicellular organismal process 2063
        positive regulation of cytokine production 503
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
            MDA-5 signaling pathway 8
              negative regulation of MDA-5 signaling pathway 4
              positive regulation of MDA-5 signaling pathway 4
              regulation of MDA-5 signaling pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          gene expression 6295
            cytokine production 846
              regulation of cytokine production 762
                positive regulation of cytokine production 503
                  cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
                    MDA-5 signaling pathway 8
                      negative regulation of MDA-5 signaling pathway 4
                      positive regulation of MDA-5 signaling pathway 4
                      regulation of MDA-5 signaling pathway + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.