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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of MDA-5 signaling pathway
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Accession:GO:0039534 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of IFIH1 signaling pathway;   negative regulation of MDA-5 signalling pathway;   negative regulation of MDA5 signaling pathway;   negative regulation of melanoma differentiation-associated gene 5 signaling pathway


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negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Tkfc triokinase and FMN cyclase JBrowse link 1 226,642,901 226,657,698 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8952
      cytokine production 842
        positive regulation of cytokine production 500
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
            MDA-5 signaling pathway 8
              negative regulation of MDA-5 signaling pathway 4
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      organic substance metabolic process 11494
        macromolecule metabolic process 9943
          gene expression 6164
            cytokine production 842
              regulation of cytokine production 759
                positive regulation of cytokine production 500
                  cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
                    regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 21
                      negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                        negative regulation of MDA-5 signaling pathway 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.