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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein ISO (PMID:19164550) UniProtKB PMID:19164550 NCBI chr17:5,481,114...5,487,482
Ensembl chr17:5,473,239...5,479,735
JBrowse link
G DHX58 DExH-box helicase 58 ISO (MGI:MGI:3836702|PMID:17475874)
(PMID:18411269)
(PMID:21187438)
UniProtKB PMID:17475874, PMID:18411269, PMID:21187438 MGI:MGI:3836702 NCBI chr17:15,203,216...15,214,559
Ensembl chr17:15,424,437...15,435,582
JBrowse link
G GPATCH3 G-patch domain containing 3 ISO (PMID:28414768) UniProtKB PMID:28414768 NCBI chr 1:26,153,078...26,163,181
Ensembl chr 1:27,209,795...27,220,107
JBrowse link
G NLRX1 NLR family member X1 ISO (MGI:MGI:5050761|PMID:21703540) MGI PMID:21703540 MGI:MGI:5050761 NCBI chr11:114,007,415...114,022,712
Ensembl chr11:117,935,444...117,950,728
JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chr17:76,012,756...76,092,901
Ensembl chr17:81,713,582...81,788,714
JBrowse link
G RNF125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chr18:25,227,353...25,297,186
Ensembl chr18:28,824,183...28,873,068
JBrowse link
G SEC14L1 SEC14 like lipid binding 1 ISO (PMID:23843640) UniProtKB PMID:23843640 NCBI chr17:71,221,870...71,297,142
Ensembl chr17:76,785,559...76,857,848
JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chr22:2,209,590...2,238,449
Ensembl chr22:17,885,073...17,913,506
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    immune system process 2076
      immune effector process 669
        defense response to virus 202
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
            RIG-I signaling pathway 25
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 12564
    biological regulation 9168
      regulation of biological process 8671
        regulation of cellular process 8197
          signal transduction 3812
            pattern recognition receptor signaling pathway 148
              cytoplasmic pattern recognition receptor signaling pathway 49
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
                  regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 20
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                      negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.