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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein ISO (PMID:19164550) UniProtKB PMID:19164550 NCBI chrNW_004955467:10,788,142...10,792,272
Ensembl chrNW_004955467:10,788,277...10,792,449
JBrowse link
G Dhx58 DExH-box helicase 58 ISO (PMID:21187438)
(PMID:18411269)
(MGI:MGI:3836702|PMID:17475874)
UniProtKB PMID:17475874, PMID:18411269, PMID:21187438 MGI:MGI:3836702 NCBI chrNW_004955451:16,186,263...16,191,928
Ensembl chrNW_004955451:16,185,510...16,191,719
JBrowse link
G Gpatch3 G-patch domain containing 3 ISO (PMID:28414768) UniProtKB PMID:28414768 NCBI chrNW_004955452:6,234,241...6,241,949
Ensembl chrNW_004955452:6,234,241...6,241,991
JBrowse link
G Nlrx1 NLR family member X1 ISO (MGI:MGI:5050761|PMID:21703540) MGI PMID:21703540 MGI:MGI:5050761 NCBI chrNW_004955412:20,275,767...20,287,414
Ensembl chrNW_004955412:20,275,917...20,287,414
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chrNW_004955506:1,451,337...1,513,455
Ensembl chrNW_004955506:1,451,337...1,513,455
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chrNW_004955402:19,276,157...19,310,605
Ensembl chrNW_004955402:19,295,809...19,309,987
JBrowse link
G Sec14l1 SEC14 like lipid binding 1 ISO (PMID:23843640) UniProtKB PMID:23843640 NCBI chrNW_004955506:5,159,090...5,231,827
Ensembl chrNW_004955506:5,158,805...5,232,551
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chrNW_004955442:18,548,545...18,568,989
Ensembl chrNW_004955442:18,548,545...18,569,366
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11889
    immune system process 1907
      immune effector process 592
        defense response to virus 177
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
            RIG-I signaling pathway 25
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 11889
    biological regulation 8722
      regulation of biological process 8267
        regulation of cellular process 7843
          signal transduction 3676
            pattern recognition receptor signaling pathway 146
              cytoplasmic pattern recognition receptor signaling pathway 48
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
                  regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 20
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                      negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.