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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein IDA (PMID:19164550) UniProtKB PMID:19164550 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830
JBrowse link
G DHX58 DExH-box helicase 58 IDA
IMP
(PMID:18411269)
(PMID:21187438)
UniProtKB PMID:18411269, PMID:21187438 NCBI chr17:42,101,404...42,112,721
Ensembl chr17:42,101,404...42,112,714
JBrowse link
G GPATCH3 G-patch domain containing 3 IMP
IBA
IEA
(PMID:28414768)
(PMID:21873635)
UniProtKB
GO_Central
InterPro
PMID:21873635, PMID:28414768 GO_REF:0000002 NCBI chr 1:26,890,488...26,900,467
Ensembl chr 1:26,890,488...26,900,467
JBrowse link
G NLRX1 NLR family member X1 IEA Ensembl GO_REF:0000107 NCBI chr11:119,168,334...119,184,016
Ensembl chr11:119,166,568...119,184,016
JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor IMP (PMID:26471729) UniProtKB PMID:26471729 NCBI chr17:81,556,885...81,637,148
Ensembl chr17:81,556,887...81,648,465
JBrowse link
G RNF125 ring finger protein 125 IDA (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chr18:32,018,585...32,090,756
Ensembl chr18:32,018,825...32,073,219
JBrowse link
G SEC14L1 SEC14 like lipid binding 1 IMP (PMID:23843640) UniProtKB PMID:23843640 NCBI chr17:77,088,685...77,217,101
Ensembl chr17:77,088,749...77,217,101
JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 IMP (PMID:26471729) UniProtKB PMID:26471729 NCBI chr22:19,449,911...19,479,193
Ensembl chr22:19,449,911...19,479,202
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    immune system process 3586
      immune effector process 1414
        defense response to virus 284
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 34
            RIG-I signaling pathway 28
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 18670
    biological regulation 13308
      regulation of biological process 12640
        regulation of cellular process 12035
          signal transduction 6573
            pattern recognition receptor signaling pathway 216
              cytoplasmic pattern recognition receptor signaling pathway 76
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 34
                  regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 23
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                      negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.