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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement component 1, q subcomponent binding protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:70,977,846...70,983,026
Ensembl chr11:70,977,836...70,983,026
JBrowse link
G Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 IMP
ISO
(MGI:MGI:3836702|PMID:17475874) UniProtKB
MGI
PMID:17475874 GO_REF:0000096, MGI:MGI:3836702, MGI:MGI:4834177 NCBI chr11:100,694,884...100,704,271
Ensembl chr11:100,694,884...100,704,271
JBrowse link
G Gpatch3 G patch domain containing 3 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 4:133,574,745...133,584,242
Ensembl chr 4:133,574,745...133,584,243
JBrowse link
G Nlrx1 NLR family member X1 IMP (MGI:MGI:5050761|PMID:21703540) MGI PMID:21703540 MGI:MGI:5050761 NCBI chr 9:44,252,713...44,268,599
Ensembl chr 9:44,252,717...44,268,599
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:120,379,798...120,437,700
Ensembl chr11:120,380,370...120,437,708
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chr18:20,944,615...20,987,359
Ensembl chr18:20,944,625...20,983,862
JBrowse link
G Sec14l1 SEC14-like lipid binding 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:117,115,168...117,159,268
Ensembl chr11:117,115,168...117,159,268
JBrowse link
G Ufd1 ubiquitin recognition factor in ER-associated degradation 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:18,811,736...18,835,261
Ensembl chr16:18,811,779...18,835,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    immune system process 2929
      immune effector process 950
        defense response to virus 255
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
            RIG-I signaling pathway 25
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 23386
    biological regulation 13112
      regulation of biological process 12478
        regulation of cellular process 11921
          signal transduction 6323
            pattern recognition receptor signaling pathway 163
              cytoplasmic pattern recognition receptor signaling pathway 51
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
                  regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 20
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                      negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.