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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein IEA Ensembl GO_REF:0000107 NCBI chr12:51,548,361...51,553,076
Ensembl chr12:51,548,415...51,555,689
JBrowse link
G DHX58 DExH-box helicase 58 IEA Ensembl GO_REF:0000107 NCBI chr12:20,647,698...20,656,691
Ensembl chr12:20,647,692...20,656,692
JBrowse link
G GPATCH3 G-patch domain containing 3 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 6:84,200,727...84,218,710
Ensembl chr 6:84,200,724...84,218,773
JBrowse link
G NLRX1 NLR family member X1 IEA Ensembl GO_REF:0000107 NCBI chr 9:46,384,373...46,400,752
Ensembl chr 9:46,384,375...46,400,750
JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor IEA Ensembl GO_REF:0000107 NCBI chr12:1,251,377...1,285,668
Ensembl chr12:1,251,053...1,285,666
JBrowse link
G RNF125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chr 6:115,857,697...115,905,550
Ensembl chr 6:115,857,084...115,903,696
JBrowse link
G SEC14L1 SEC14 like lipid binding 1 IEA Ensembl GO_REF:0000107 NCBI chr12:4,439,045...4,489,078
Ensembl chr12:4,441,114...4,489,080
JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 IEA Ensembl GO_REF:0000107 NCBI chr14:51,113,858...51,132,820
Ensembl chr14:51,113,713...51,133,072
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    immune system process 2305
      immune effector process 711
        defense response to virus 224
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
            RIG-I signaling pathway 25
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 16545
    biological regulation 12011
      regulation of biological process 11420
        regulation of cellular process 10970
          signal transduction 5925
            pattern recognition receptor signaling pathway 152
              cytoplasmic pattern recognition receptor signaling pathway 47
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
                  regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 20
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                      negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.