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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
RGD:1600115
G Gpatch3 G patch domain containing 3 JBrowse link 5 151,796,456 151,806,007 RGD:1624291
RGD:13792537
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:1600115
RGD:1624291
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
RGD:1600115
G Sec14l1 SEC14-like lipid binding 1 JBrowse link 10 106,065,712 106,112,859 RGD:1624291
RGD:1600115
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    cellular process 16139
      multi-organism cellular process 48
        cytoplasmic pattern recognition receptor signaling pathway in response to virus 24
          RIG-I signaling pathway 19
            negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 18008
    response to stimulus 9859
      response to external stimulus 2924
        response to external biotic stimulus 1470
          response to other organism 1466
            defense response to other organism 905
              innate immune response 651
                regulation of innate immune response 303
                  positive regulation of innate immune response 243
                    activation of innate immune response 178
                      innate immune response-activating signal transduction 151
                        pattern recognition receptor signaling pathway 149
                          cytoplasmic pattern recognition receptor signaling pathway 41
                            cytoplasmic pattern recognition receptor signaling pathway in response to virus 24
                              regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 19
                                negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                                  negative regulation of RIG-I signaling pathway 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.