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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein ISO
ISS
(PMID:19164550)
GO_REF:0000024
RGD
UniProt
PMID:19164550 GO_REF:0000024 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Dhx58 DEXH-box helicase 58 ISO (MGI:MGI:3836702|PMID:17475874)
(PMID:18411269), (PMID:21187438)
RGD PMID:17475874, PMID:18411269, PMID:21187438 MGI:MGI:3836702 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Gpatch3 G patch domain containing 3 ISO
IBA
(PMID:28414768)
PMID:21873635
RGD PMID:28414768, PMID:21873635 RGD:13792537 NCBI chr 5:151,796,456...151,806,007
Ensembl chr 5:151,796,814...151,805,976
JBrowse link
G Nlrx1 NLR family member X1 ISO
IEA
MGI:MGI:5141085 (MGI:MGI:5050761|PMID:21703540)
GO_REF:0000107
RGD
Ensembl
PMID:21703540 GO_REF:0000107, MGI:MGI:5050761 NCBI chr 8:48,583,559...48,600,203
Ensembl chr 8:48,584,071...48,597,867
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26471729)
Ensembl
UniProt
RGD
PMID:26471729 GO_REF:0000024, GO_REF:0000107 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) RGD PMID:17460044, PMID:26471729 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Sec14l1 SEC14-like lipid binding 1 ISO (PMID:23843640) RGD PMID:23843640 NCBI chr10:106,065,712...106,112,859
Ensembl chr10:106,065,712...106,112,857
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO
ISS
(PMID:26471729)
GO_REF:0000024
RGD
UniProt
PMID:26471729 GO_REF:0000024 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    multicellular organismal process 9055
      cytokine production 846
        positive regulation of cytokine production 503
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
            RIG-I signaling pathway 26
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          gene expression 6295
            cytokine production 846
              regulation of cytokine production 762
                positive regulation of cytokine production 503
                  cytoplasmic pattern recognition receptor signaling pathway in response to virus 30
                    regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 21
                      negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                        negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.