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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of RIG-I signaling pathway
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Accession:GO:0039536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
Synonyms:exact_synonym: negative regulation of DDX58 signaling pathway;   negative regulation of RIG-I signalling pathway;   negative regulation of retinoic acid inducible gene I signaling pathway


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negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein ISO (PMID:19164550) UniProtKB PMID:19164550 NCBI chrNW_004936677:2,371,400...2,376,608 JBrowse link
G Dhx58 DExH-box helicase 58 ISO (MGI:MGI:3836702|PMID:17475874)
(PMID:21187438)
(PMID:18411269)
UniProtKB PMID:17475874, PMID:18411269, PMID:21187438 MGI:MGI:3836702 NCBI chrNW_004936490:16,940,776...16,949,836 JBrowse link
G Gpatch3 G-patch domain containing 3 ISO (PMID:28414768) UniProtKB PMID:28414768 NCBI chrNW_004936474:11,298,802...11,310,609 JBrowse link
G Nlrx1 NLR family member X1 ISO (MGI:MGI:5050761|PMID:21703540) MGI PMID:21703540 MGI:MGI:5050761 NCBI chrNW_004936542:4,105,980...4,121,176 JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chrNW_004936594:5,206,222...5,251,042 JBrowse link
G Rnf125 ring finger protein 125 ISO (PMID:17460044), (PMID:26471729) UniProtKB PMID:17460044, PMID:26471729 NCBI chrNW_004936682:1,228,903...1,268,651 JBrowse link
G Sec14l1 SEC14 like lipid binding 1 ISO (PMID:23843640) UniProtKB PMID:23843640 NCBI chrNW_004936594:2,048,146...2,100,808 JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 ISO (PMID:26471729) UniProtKB PMID:26471729 NCBI chrNW_004936619:3,395,130...3,419,704 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    immune system process 1919
      immune effector process 593
        defense response to virus 175
          cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
            RIG-I signaling pathway 25
              negative regulation of RIG-I signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 12001
    biological regulation 8793
      regulation of biological process 8336
        regulation of cellular process 7913
          signal transduction 3699
            pattern recognition receptor signaling pathway 144
              cytoplasmic pattern recognition receptor signaling pathway 49
                cytoplasmic pattern recognition receptor signaling pathway in response to virus 29
                  regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 20
                    negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 11
                      negative regulation of RIG-I signaling pathway 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.