ONTOLOGY REPORT - ANNOTATIONS


Term:chemokine biosynthetic process
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Accession:GO:0042033 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
Synonyms:exact_synonym: chemokine anabolism;   chemokine biosynthesis;   chemokine formation;   chemokine synthesis


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negative regulation of chemokine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elane elastase, neutrophil expressed JBrowse link 7 12,638,320 12,640,168 RGD:1624291
RGD:1600115
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
RGD:1600115
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:1624291
RGD:1600115
positive regulation of chemokine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1600115
RGD:1624291
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:1600115
RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
RGD:1600115
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:1624291
RGD:1600115
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 9 10,780,185 10,790,280 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291
positive regulation of fractalkine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC103694380 tumor necrosis factor-like JBrowse link 20 4,855,792 4,858,447 RGD:13673777
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:13673777

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17926
    multicellular organismal process 8539
      cytokine production 775
        chemokine production 93
          chemokine biosynthetic process 15
            fractalkine biosynthetic process + 2
            negative regulation of chemokine biosynthetic process + 3
            positive regulation of chemokine biosynthetic process + 12
            regulation of chemokine biosynthetic process + 15
Path 2
Term Annotations click to browse term
  biological_process 17926
    metabolic process 10677
      organic substance metabolic process 10127
        organonitrogen compound metabolic process 6341
          protein metabolic process 5526
            cytokine metabolic process 118
              cytokine biosynthetic process 114
                chemokine biosynthetic process 15
                  fractalkine biosynthetic process + 2
                  negative regulation of chemokine biosynthetic process + 3
                  positive regulation of chemokine biosynthetic process + 12
                  regulation of chemokine biosynthetic process + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.