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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cytokine biosynthetic process
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Accession:GO:0042036 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
Synonyms:exact_synonym: down regulation of cytokine biosynthetic process;   downregulation of cytokine biosynthetic process;   negative regulation of cytokine anabolism;   negative regulation of cytokine biosynthesis;   negative regulation of cytokine formation;   negative regulation of cytokine synthesis
 narrow_synonym: inhibition of cytokine biosynthetic process


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negative regulation of cytokine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Rnf128 ring finger protein 128 JBrowse link X 110,789,061 110,877,964 RGD:1624291
RGD:1600115
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein JBrowse link 4 118,207,845 118,238,246 RGD:1624291
RGD:1600115
negative regulation of chemokine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elane elastase, neutrophil expressed JBrowse link 7 12,638,320 12,640,168 RGD:1624291
RGD:1600115
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
RGD:1600115
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:1624291
RGD:1600115
negative regulation of hepatocyte growth factor biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inhbb inhibin subunit beta B JBrowse link 13 35,436,532 35,442,222 RGD:1600115
RGD:1624291
negative regulation of interferon-alpha biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nmi N-myc (and STAT) interactor JBrowse link 3 37,458,891 37,480,984 RGD:1624291
negative regulation of interferon-beta biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:1624291
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:1624291
G Nmi N-myc (and STAT) interactor JBrowse link 3 37,458,891 37,480,984 RGD:1624291
negative regulation of interferon-gamma biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd276 Cd276 molecule JBrowse link 8 63,312,060 63,350,411 RGD:1624291
RGD:1600115
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
RGD:1600115
negative regulation of interleukin-10 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trib2 tribbles pseudokinase 2 JBrowse link 6 41,016,722 41,040,972 RGD:1624291
RGD:1600115
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:1624291
negative regulation of interleukin-12 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:1624291
RGD:1600115
negative regulation of interleukin-2 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd276 Cd276 molecule JBrowse link 8 63,312,060 63,350,411 RGD:1624291
RGD:1600115
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
RGD:1600115
G Lag3 lymphocyte activating 3 JBrowse link 4 157,425,644 157,433,700 RGD:1624291
RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Zfp36 zinc finger protein 36 JBrowse link 1 85,380,088 85,382,565 RGD:1600115
RGD:1624291
negative regulation of interleukin-4 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zfpm1 zinc finger protein, multitype 1 JBrowse link 19 55,094,585 55,150,994 RGD:1624291
RGD:1600115
negative regulation of interleukin-6 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxj1 forkhead box J1 JBrowse link 10 105,282,090 105,289,396 RGD:1624291
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1624291
RGD:1600115
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:1624291
RGD:1600115
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:1624291
RGD:1600115
G Muc16 mucin 16, cell surface associated JBrowse link 8 18,438,838 18,639,777 RGD:1624291
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
RGD:13792537
G Prg4 proteoglycan 4 JBrowse link 13 67,672,588 67,688,902 RGD:1624291
negative regulation of interleukin-8 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
RGD:1600115
G Elane elastase, neutrophil expressed JBrowse link 7 12,638,320 12,640,168 RGD:1624291
RGD:1600115
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:1624291
RGD:1600115
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:8553940
negative regulation of tumor necrosis factor biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:9685562
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1624291
RGD:1600115
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:1624291
RGD:1600115
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1598631
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    multicellular organismal process 8585
      cytokine production 783
        negative regulation of cytokine production 271
          negative regulation of cytokine biosynthetic process 31
            negative regulation of TRAIL biosynthetic process 0
            negative regulation of chemokine biosynthetic process + 3
            negative regulation of connective tissue growth factor biosynthetic process 0
            negative regulation of cytokine biosynthetic process involved in immune response 0
            negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process 0
            negative regulation of hepatocyte growth factor biosynthetic process 1
            negative regulation of interferon-alpha biosynthetic process 1
            negative regulation of interferon-beta biosynthetic process 3
            negative regulation of interferon-gamma biosynthetic process 2
            negative regulation of interleukin-1 biosynthetic process + 0
            negative regulation of interleukin-10 biosynthetic process 2
            negative regulation of interleukin-11 biosynthetic process 0
            negative regulation of interleukin-12 biosynthetic process 1
            negative regulation of interleukin-13 biosynthetic process 0
            negative regulation of interleukin-14 biosynthetic process 0
            negative regulation of interleukin-15 biosynthetic process 0
            negative regulation of interleukin-16 biosynthetic process 0
            negative regulation of interleukin-17 biosynthetic process + 0
            negative regulation of interleukin-18 biosynthetic process 0
            negative regulation of interleukin-19 biosynthetic process 0
            negative regulation of interleukin-2 biosynthetic process 5
            negative regulation of interleukin-20 biosynthetic process 0
            negative regulation of interleukin-21 biosynthetic process 0
            negative regulation of interleukin-22 biosynthetic process 0
            negative regulation of interleukin-23 biosynthetic process 0
            negative regulation of interleukin-24 biosynthetic process 0
            negative regulation of interleukin-26 biosynthetic process 0
            negative regulation of interleukin-27 biosynthetic process 0
            negative regulation of interleukin-3 biosynthetic process 0
            negative regulation of interleukin-35 biosynthetic process 0
            negative regulation of interleukin-4 biosynthetic process 1
            negative regulation of interleukin-5 biosynthetic process 0
            negative regulation of interleukin-6 biosynthetic process 7
            negative regulation of interleukin-7 biosynthetic process 0
            negative regulation of interleukin-8 biosynthetic process 4
            negative regulation of interleukin-9 biosynthetic process 0
            negative regulation of lymphotoxin A biosynthetic process 0
            negative regulation of tumor necrosis factor biosynthetic process 6
Path 2
Term Annotations click to browse term
  biological_process 18008
    metabolic process 10729
      organic substance metabolic process 10177
        macromolecule metabolic process 8720
          protein metabolic process 5543
            cytokine metabolic process 120
              cytokine biosynthetic process 116
                regulation of cytokine biosynthetic process 105
                  negative regulation of cytokine biosynthetic process 31
                    negative regulation of TRAIL biosynthetic process 0
                    negative regulation of chemokine biosynthetic process + 3
                    negative regulation of connective tissue growth factor biosynthetic process 0
                    negative regulation of cytokine biosynthetic process involved in immune response 0
                    negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process 0
                    negative regulation of hepatocyte growth factor biosynthetic process 1
                    negative regulation of interferon-alpha biosynthetic process 1
                    negative regulation of interferon-beta biosynthetic process 3
                    negative regulation of interferon-gamma biosynthetic process 2
                    negative regulation of interleukin-1 biosynthetic process + 0
                    negative regulation of interleukin-10 biosynthetic process 2
                    negative regulation of interleukin-11 biosynthetic process 0
                    negative regulation of interleukin-12 biosynthetic process 1
                    negative regulation of interleukin-13 biosynthetic process 0
                    negative regulation of interleukin-14 biosynthetic process 0
                    negative regulation of interleukin-15 biosynthetic process 0
                    negative regulation of interleukin-16 biosynthetic process 0
                    negative regulation of interleukin-17 biosynthetic process + 0
                    negative regulation of interleukin-18 biosynthetic process 0
                    negative regulation of interleukin-19 biosynthetic process 0
                    negative regulation of interleukin-2 biosynthetic process 5
                    negative regulation of interleukin-20 biosynthetic process 0
                    negative regulation of interleukin-21 biosynthetic process 0
                    negative regulation of interleukin-22 biosynthetic process 0
                    negative regulation of interleukin-23 biosynthetic process 0
                    negative regulation of interleukin-24 biosynthetic process 0
                    negative regulation of interleukin-26 biosynthetic process 0
                    negative regulation of interleukin-27 biosynthetic process 0
                    negative regulation of interleukin-3 biosynthetic process 0
                    negative regulation of interleukin-35 biosynthetic process 0
                    negative regulation of interleukin-4 biosynthetic process 1
                    negative regulation of interleukin-5 biosynthetic process 0
                    negative regulation of interleukin-6 biosynthetic process 7
                    negative regulation of interleukin-7 biosynthetic process 0
                    negative regulation of interleukin-8 biosynthetic process 4
                    negative regulation of interleukin-9 biosynthetic process 0
                    negative regulation of lymphotoxin A biosynthetic process 0
                    negative regulation of tumor necrosis factor biosynthetic process 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.