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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of epidermal growth factor receptor signaling pathway
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Accession:GO:0042059 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms:exact_synonym: down regulation of epidermal growth factor receptor signaling pathway;   downregulation of epidermal growth factor receptor signaling pathway;   negative regulation of EGF receptor signaling pathway;   negative regulation of EGF receptor signalling pathway;   negative regulation of EGFR signaling pathway
 narrow_synonym: inhibition of epidermal growth factor receptor signaling pathway


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negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:1624291
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:632628
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:9685562
RGD:13792537
RGD:1624291
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:1624291
RGD:1600115
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:1624291
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1642757
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Rnf115 ring finger protein 115 JBrowse link 2 198,852,392 198,920,000 RGD:1624291
G Rnf126 ring finger protein 126 JBrowse link 7 12,820,796 12,828,325 RGD:1624291
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:1624291
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1624291
G Zfyve28 zinc finger FYVE-type containing 28 JBrowse link 14 81,725,513 81,811,142 RGD:1624291
epidermal growth factor catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:1624291
G Snx5 sorting nexin 5 JBrowse link 3 138,378,032 138,397,944 RGD:13508623
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:13792537
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:13792537
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:1624291
RGD:13792537
G Chmp6 charged multivesicular body protein 6 JBrowse link 10 109,073,678 109,079,348 RGD:1624291
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:8553726
RGD:1600115
RGD:1624291
G Gprc5a G protein-coupled receptor, class C, group 5, member A JBrowse link 4 168,832,937 168,851,650 RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:1624291
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1624291
G Vps25 vacuolar protein sorting 25 homolog JBrowse link 10 89,174,684 89,180,165 RGD:1624291
G Zfyve28 zinc finger FYVE-type containing 28 JBrowse link 14 81,725,513 81,811,142 RGD:1624291
RGD:13792537
G Zgpat zinc finger CCCH-type and G-patch domain containing JBrowse link 3 176,865,078 176,881,603 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19334
    cellular process 17238
      signal transduction 6872
        negative regulation of signal transduction 1213
          negative regulation of ERBB signaling pathway 29
            negative regulation of epidermal growth factor receptor signaling pathway 27
              epidermal growth factor catabolic process 2
              negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
              negative regulation of epidermal growth factor receptor signaling pathway involved in heart process 0
              negative regulation of epidermal growth factor-activated receptor activity 14
Path 2
Term Annotations click to browse term
  biological_process 19334
    biological regulation 13336
      regulation of biological process 12651
        regulation of cellular process 11990
          signal transduction 6872
            cell surface receptor signaling pathway 2674
              enzyme linked receptor protein signaling pathway 925
                transmembrane receptor protein tyrosine kinase signaling pathway 585
                  ERBB signaling pathway 111
                    epidermal growth factor receptor signaling pathway 100
                      regulation of epidermal growth factor receptor signaling pathway 67
                        negative regulation of epidermal growth factor receptor signaling pathway 27
                          epidermal growth factor catabolic process 2
                          negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
                          negative regulation of epidermal growth factor receptor signaling pathway involved in heart process 0
                          negative regulation of epidermal growth factor-activated receptor activity 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.