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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of epidermal growth factor receptor signaling pathway
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Accession:GO:0042059 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms:exact_synonym: down regulation of epidermal growth factor receptor signaling pathway;   downregulation of epidermal growth factor receptor signaling pathway;   negative regulation of EGF receptor signaling pathway;   negative regulation of EGF receptor signalling pathway;   negative regulation of EGFR signaling pathway
 narrow_synonym: inhibition of epidermal growth factor receptor signaling pathway


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negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AREG amphiregulin JBrowse link 4 74,445,136 74,455,005 RGD:2290271
G ARHGEF7 Rho guanine nucleotide exchange factor 7 JBrowse link 13 111,114,619 111,305,734 RGD:2290271
G BTC betacellulin JBrowse link 4 74,744,759 74,794,718 RGD:2290271
G CBL Cbl proto-oncogene JBrowse link 11 119,206,339 119,308,149 RGD:2290271
G CBLC Cbl proto-oncogene C JBrowse link 19 44,777,855 44,800,652 RGD:2290271
G CDC42 cell division cycle 42 JBrowse link 1 22,052,709 22,101,360 RGD:2290271
G DAB2IP DAB2 interacting protein JBrowse link 9 121,566,883 121,785,530 RGD:2290271
G DUSP3 dual specificity phosphatase 3 JBrowse link 17 43,766,125 43,778,977 RGD:2290271
G EGF epidermal growth factor JBrowse link 4 109,912,883 110,013,766 RGD:2290271
G EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:2290271
G EPGN epithelial mitogen JBrowse link 4 74,307,585 74,316,789 RGD:2290271
G EPN1 epsin 1 JBrowse link 19 55,675,195 55,709,533 RGD:2290271
G EPS15 epidermal growth factor receptor pathway substrate 15 JBrowse link 1 51,354,263 51,519,275 RGD:2290271
G EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 JBrowse link 19 16,355,244 16,472,012 RGD:2290271
G EREG epiregulin JBrowse link 4 74,365,145 74,388,749 RGD:2290271
G ERRFI1 ERBB receptor feedback inhibitor 1 JBrowse link 1 8,011,725 8,026,309 RGD:2290271
G GRB2 growth factor receptor bound protein 2 JBrowse link 17 75,318,076 75,405,709 RGD:2290271
G HBEGF heparin binding EGF like growth factor JBrowse link 5 140,332,843 140,346,603 RGD:2290271
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 17 81,684,011 81,702,121 RGD:2290271
G ITGA1 integrin subunit alpha 1 JBrowse link 5 52,787,916 52,959,209 RGD:2290271
G NPPA natriuretic peptide A JBrowse link 1 11,845,709 11,847,783 RGD:2290271
G NUP62 nucleoporin 62 JBrowse link 19 49,906,825 49,929,504 RGD:2290271
G PTPN2 protein tyrosine phosphatase non-receptor type 2 JBrowse link 18 12,785,478 12,884,351 RGD:2290271
G PTPN3 protein tyrosine phosphatase non-receptor type 3 JBrowse link 9 109,375,694 109,538,395 RGD:2290271
G PTPRJ protein tyrosine phosphatase receptor type J JBrowse link 11 47,980,504 48,170,839 RGD:2290271
G RNF115 ring finger protein 115 JBrowse link 1 145,738,868 145,824,095 RGD:2290271
G RNF126 ring finger protein 126 JBrowse link 19 647,526 663,214 RGD:2290271
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 JBrowse link 9 17,579,066 17,797,124 RGD:2290271
G SH3KBP1 SH3 domain containing kinase binding protein 1 JBrowse link X 19,533,965 19,887,600 RGD:2290271
G SPRY1 sprouty RTK signaling antagonist 1 JBrowse link 4 123,396,795 123,403,760 RGD:2290271
G SPRY2 sprouty RTK signaling antagonist 2 JBrowse link 13 80,335,976 80,341,126 RGD:2290271
G STAM signal transducing adaptor molecule JBrowse link 10 17,644,150 17,716,824 RGD:2290271
G STAM2 signal transducing adaptor molecule 2 JBrowse link 2 152,116,801 152,175,777 RGD:2290271
G TGFA transforming growth factor alpha JBrowse link 2 70,447,284 70,553,826 RGD:2290271
G TSG101 tumor susceptibility 101 JBrowse link 11 18,480,311 18,526,942 RGD:2290271
G ZFYVE28 zinc finger FYVE-type containing 28 JBrowse link 4 2,269,585 2,418,698 RGD:2290271
epidermal growth factor catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RAB7A RAB7A, member RAS oncogene family JBrowse link 3 128,726,183 128,814,798 RGD:2290271
G SNX5 sorting nexin 5 JBrowse link 20 17,941,600 17,968,794 RGD:2290271
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CBL Cbl proto-oncogene JBrowse link 11 119,206,339 119,308,149 RGD:2290271
G CBLB Cbl proto-oncogene B JBrowse link 3 105,655,461 105,869,552 RGD:2290271
G CBLC Cbl proto-oncogene C JBrowse link 19 44,777,855 44,800,652 RGD:2290271
G CHMP6 charged multivesicular body protein 6 JBrowse link 17 80,991,841 81,000,133 RGD:2290271
G ERRFI1 ERBB receptor feedback inhibitor 1 JBrowse link 1 8,011,725 8,026,309 RGD:2290271
G GPRC5A G protein-coupled receptor class C group 5 member A JBrowse link 12 12,891,562 12,917,937 RGD:2290271
G PSEN1 presenilin 1 JBrowse link 14 73,136,436 73,223,691 RGD:2290271
G SNX6 sorting nexin 6 JBrowse link 14 34,561,093 34,630,148 RGD:2290271
G SOCS4 suppressor of cytokine signaling 4 JBrowse link 14 55,027,131 55,049,489 RGD:2290271
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 2 46,698,960 46,763,129 RGD:2290271
G TSG101 tumor susceptibility 101 JBrowse link 11 18,480,311 18,526,942 RGD:2290271
G VPS25 vacuolar protein sorting 25 homolog JBrowse link 17 42,773,449 42,779,599 RGD:2290271
G ZFYVE28 zinc finger FYVE-type containing 28 JBrowse link 4 2,269,585 2,418,698 RGD:2290271
G ZGPAT zinc finger CCCH-type and G-patch domain containing JBrowse link 20 63,707,442 63,736,142 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17988
    cellular process 16264
      signal transduction 6305
        negative regulation of signal transduction 1276
          negative regulation of ERBB signaling pathway 52
            negative regulation of epidermal growth factor receptor signaling pathway 47
              epidermal growth factor catabolic process 2
              negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
              negative regulation of epidermal growth factor receptor signaling pathway involved in heart process 0
              negative regulation of epidermal growth factor-activated receptor activity 14
Path 2
Term Annotations click to browse term
  biological_process 17988
    biological regulation 12616
      regulation of biological process 11926
        regulation of cellular process 11208
          signal transduction 6305
            cell surface receptor signaling pathway 3207
              enzyme linked receptor protein signaling pathway 1055
                transmembrane receptor protein tyrosine kinase signaling pathway 727
                  ERBB signaling pathway 143
                    epidermal growth factor receptor signaling pathway 120
                      regulation of epidermal growth factor receptor signaling pathway 86
                        negative regulation of epidermal growth factor receptor signaling pathway 47
                          epidermal growth factor catabolic process 2
                          negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
                          negative regulation of epidermal growth factor receptor signaling pathway involved in heart process 0
                          negative regulation of epidermal growth factor-activated receptor activity 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.