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ONTOLOGY REPORT - ANNOTATIONS


Term:T-helper 1 type immune response
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Accession:GO:0042088 term browser browse the term
Definition:An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.
Synonyms:exact_synonym: Th1 immune response


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T-helper 1 type immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:8554620
G Il18bp interleukin 18 binding protein JBrowse link 1 167,091,521 167,095,727 RGD:1624291
RGD:13792537
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:1624291
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:1624291
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1580562
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
RGD:1600115
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
negative regulation of T-helper 1 type immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:1624291
RGD:1600115
G Il33 interleukin 33 JBrowse link 1 248,112,611 248,147,030 RGD:1624291
RGD:1600115
positive regulation of T-helper 1 cell cytokine production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arid5a AT-rich interaction domain 5A JBrowse link 9 42,871,907 42,886,725 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1600115
RGD:1624291
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:1600115
RGD:1624291
G Xcl1 X-C motif chemokine ligand 1 JBrowse link 13 83,199,402 83,202,845 RGD:1624291
RGD:1600115
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
RGD:1600115
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Hlx H2.0-like homeobox JBrowse link 13 102,637,967 102,643,376 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
positive regulation of T-helper 1 type immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr2 C-C motif chemokine receptor 2 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:1624291
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:1624291
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:1624291
G Nlrp10 NLR family, pyrin domain containing 10 JBrowse link 1 173,521,412 173,528,969 RGD:1624291
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1600115
RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:1624291
RGD:1600115
G Slc11a1 solute carrier family 11 member 1 JBrowse link 9 81,655,590 81,666,697 RGD:1624291
RGD:1600115
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il27 interleukin 27 JBrowse link 1 198,003,615 198,010,112 RGD:1624291
RGD:13792537
T-helper 1 cell cytokine production term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:1600115
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:1624291
G Slamf1 signaling lymphocytic activation molecule family member 1 JBrowse link 13 90,184,545 90,219,170 RGD:1624291
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:1624291
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:1600115
RGD:1624291
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:1624291
G Sema4a semaphorin 4A JBrowse link 2 187,799,568 187,823,014 RGD:1624291
G Tmem98 transmembrane protein 98 JBrowse link 10 68,173,380 68,184,289 RGD:1600115
RGD:1624291
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1600115
RGD:1624291
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19578
    response to stimulus 10490
      immune response 1626
        adaptive immune response 487
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 410
            T-helper 1 type immune response 47
              T-helper 1 cell cytokine production + 10
              T-helper 1 cell differentiation + 19
              negative regulation of T-helper 1 type immune response + 6
              positive regulation of T-helper 1 type immune response + 21
              regulation of T-helper 1 type immune response + 28
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.