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ONTOLOGY REPORT - ANNOTATIONS


Term:cytokine biosynthetic process
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Accession:GO:0042089 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
Synonyms:exact_synonym: cytokine anabolism;   cytokine biosynthesis;   cytokine formation;   cytokine synthesis
 narrow_synonym: induction of cytokines
 alt_id: GO:0042032


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cytokine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpe CCAAT/enhancer binding protein epsilon ISO MGI:MGI:2178607 (MGI:MGI:1336504|PMID:10216107) RGD PMID:10216107 MGI:MGI:1336504 NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138
JBrowse link
G Il17f interleukin 17F ISO (PMID:11591732) RGD PMID:11591732 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link
negative regulation of cytokine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO (PMID:11483607) RGD PMID:11483607 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Rnf128 ring finger protein 128 ISO (MGI:MGI:2656456|PMID:12705856) RGD PMID:12705856 MGI:MGI:2656456 NCBI chr  X:110,789,061...110,877,964
Ensembl chr  X:110,789,269...110,877,978
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein ISO MGI:MGI:3037091 (MGI:MGI:3037090|PMID:10921895) RGD PMID:10921895 MGI:MGI:3037090 NCBI chr 4:118,207,845...118,238,246
Ensembl chr 4:118,207,862...118,235,218
JBrowse link
negative regulation of hepatocyte growth factor biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inhbb inhibin subunit beta B IEA
ISO
ISS
GO_REF:0000107
(PMID:12419948)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:12419948 GO_REF:0000024, GO_REF:0000107 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
positive regulation of cytokine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin ISO
ISS
(PMID:10681561)
GO_REF:0000024
RGD
UniProt
PMID:10681561 GO_REF:0000024 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1a Fc fragment of IgE receptor Ia ISO (MGI:MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:MGI:85068 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Syk spleen associated tyrosine kinase ISO
IEA
MGI:MGI:2384078 (MGI:MGI:85068|PMID:9000133)
GO_REF:0000107
RGD
Ensembl
PMID:9000133 GO_REF:0000107, MGI:MGI:85068 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
regulation of cytokine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 ISO
ISS
(MGI:MGI:2159488|PMID:11093124)
GO_REF:0000024
RGD
UniProt
PMID:11093124 GO_REF:0000024, MGI:MGI:2159488 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO MGI:MGI:1857752 (MGI:MGI:1334076|PMID:10097111) RGD PMID:10097111 MGI:MGI:1334076 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Zfp287 zinc finger protein 287 ISO
IBA
(MGI:MGI:2159488|PMID:11093124)
PMID:21873635
RGD PMID:11093124, PMID:21873635 MGI:MGI:2159488, RGD:13792537 NCBI chr10:49,131,764...49,150,930
Ensembl chr10:49,135,277...49,149,479
JBrowse link
regulation of granulocyte macrophage colony-stimulating factor biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il17f interleukin 17F IEA
ISO
GO_REF:0000107
(PMID:11574464)
Ensembl
RGD
PMID:11574464 GO_REF:0000107 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    multicellular organismal process 9055
      cytokine production 846
        cytokine biosynthetic process 12
          TRAIL biosynthetic process + 0
          chemokine biosynthetic process 0
          cytokine biosynthetic process involved in immune response 0
          granulocyte macrophage colony-stimulating factor biosynthetic process + 3
          hepatocyte growth factor biosynthetic process + 1
          negative regulation of cytokine biosynthetic process + 4
          positive regulation of cytokine biosynthetic process + 3
          regulation of cytokine biosynthetic process + 11
          tumor necrosis factor biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          gene expression 6295
            cytokine production 846
              cytokine biosynthetic process 12
                TRAIL biosynthetic process + 0
                chemokine biosynthetic process 0
                cytokine biosynthetic process involved in immune response 0
                granulocyte macrophage colony-stimulating factor biosynthetic process + 3
                hepatocyte growth factor biosynthetic process + 1
                negative regulation of cytokine biosynthetic process + 4
                positive regulation of cytokine biosynthetic process + 3
                regulation of cytokine biosynthetic process + 11
                tumor necrosis factor biosynthetic process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.