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ONTOLOGY REPORT - ANNOTATIONS


Term:type 2 immune response
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Accession:GO:0042092 term browser browse the term
Definition:An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.
Synonyms:narrow_synonym: T-helper 2 type immune response;   Th2 immune response


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type 2 immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor ISO
IBA
MGI:MGI:2158438 (MGI:MGI:892135|PMID:9171827)
PMID:21873635
RGD PMID:9171827, PMID:21873635 MGI:MGI:892135, RGD:13792537 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bcl6b BCL6B, transcription repressor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:56,834,363...56,840,058
Ensembl chr10:56,834,364...56,839,437
JBrowse link
G Stard7 StAR-related lipid transfer domain containing 7 ISO MGI:MGI:4433666 (MGI:MGI:5906122|PMID:25980009) RGD PMID:25980009 MGI:MGI:5906122 NCBI chr 3:119,698,655...119,727,303
Ensembl chr 3:119,698,652...119,727,347
JBrowse link
negative regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 ISO (MGI:MGI:5908339|PMID:19360123) RGD PMID:19360123 MGI:MGI:5908339 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Ifnb1 interferon beta 1 ISO (PMID:20554961) RGD PMID:20554961 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:5543347|PMID:23616576) RGD PMID:23616576 MGI:MGI:5543347 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO
IBA
ISS
(PMID:17008549)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:17008549, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:96559 (MGI:MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:MGI:2450484 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Hlx H2.0-like homeobox ISO MGI:MGI:105367|MGI:MGI:2182089 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223
JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO (MGI:MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:MGI:3687909 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
G Zfp35 zinc finger protein 35 ISO MGI:MGI:4398896 (MGI:MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:MGI:4366385 NCBI chr18:15,883,182...15,898,803
Ensembl chr18:15,883,182...15,898,821
JBrowse link
negative regulation of type 2 immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:5810834|PMID:27214549)
Ensembl
RGD
PMID:27214549 GO_REF:0000107, MGI:MGI:5810834 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:103034 (MGI:MGI:1342381|PMID:10438949) RGD PMID:10438949 MGI:MGI:1342381 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO
ISS
(MGI:MGI:3699670|PMID:14662900)
GO_REF:0000024
RGD
BHF-UCL
PMID:14662900 GO_REF:0000024, MGI:MGI:3699670
G Ifnl1 interferon, lambda 1 ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:85,252,103...85,253,635
Ensembl chr 1:85,252,103...85,253,635
JBrowse link
G Il27ra interleukin 27 receptor subunit alpha ISO MGI:MGI:3525439 (MGI:MGI:1926579|PMID:11057672) RGD PMID:11057672 MGI:MGI:1926579 NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 ISO MGI:MGI:3695433 (MGI:MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:MGI:3694584 NCBI chr18:31,574,759...31,625,286
Ensembl chr18:31,574,821...31,625,274
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:MGI:107187 (MGI:MGI:1342381|PMID:10438949) RGD PMID:10438949 MGI:MGI:1342381 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Zfp35 zinc finger protein 35 ISO MGI:MGI:4398896 (MGI:MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:MGI:4366385 NCBI chr18:15,883,182...15,898,803
Ensembl chr18:15,883,182...15,898,821
JBrowse link
positive regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:1926561|PMID:11046035)
(PMID:8766544)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:8766544, PMID:11046035 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1926561 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Gata3 GATA binding protein 3 ISO (MGI:MGI:3046385|PMID:15087456) RGD PMID:15087456 MGI:MGI:3046385 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Il6 interleukin 6 ISO (MGI:MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:MGI:5795829 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Prkcz protein kinase C, zeta ISO
ISS
(MGI:MGI:3584076|PMID:15987782)
GO_REF:0000024
RGD
UniProt
PMID:15987782 GO_REF:0000024, MGI:MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3844206|PMID:19047684)
Ensembl
UniProt
RGD
PMID:19047684 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3844206 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 ISO
IEA
(MGI:MGI:5009207|PMID:9973465)
GO_REF:0000107
RGD
Ensembl
PMID:9973465 GO_REF:0000107, MGI:MGI:5009207 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 ISO
IEA
(MGI:MGI:3608083|PMID:12829194)
GO_REF:0000107
RGD
Ensembl
PMID:12829194 GO_REF:0000107, MGI:MGI:3608083 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il4r interleukin 4 receptor ISO MGI:MGI:96109 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 ISO (MGI:MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:MGI:2450484 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Prkcz protein kinase C, zeta ISO
ISS
(MGI:MGI:3584076|PMID:15987782)
GO_REF:0000024
RGD
UniProt
PMID:15987782 GO_REF:0000024, MGI:MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rara retinoic acid receptor, alpha ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:MGI:4943387 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
positive regulation of type 2 immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule ISO
IBA
(MGI:MGI:2158514|PMID:11823488)
PMID:21873635
RGD PMID:11823488, PMID:21873635 MGI:MGI:2158514, RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO
IEA
MGI:MGI:3505776 (MGI:MGI:3789443|PMID:18436652)
GO_REF:0000107
RGD
Ensembl
PMID:18436652 GO_REF:0000107, MGI:MGI:3789443 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Il33 interleukin 33 ISO
IEA
UniProtKB:P08226 (MGI:MGI:3775141|PMID:18268038), (MGI:MGI:5543337|PMID:23630360)
GO_REF:0000107
RGD
Ensembl
PMID:18268038, PMID:23630360 GO_REF:0000107, MGI:MGI:3775141, MGI:MGI:5543337 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO (PMID:21172192) RGD PMID:21172192 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:3763508|PMID:12496423), (MGI:MGI:4355816|PMID:17785785), (MGI:MGI:4943387|PMID:18354165) RGD PMID:12496423, PMID:17785785, PMID:18354165 MGI:MGI:3763508, MGI:MGI:4355816, MGI:MGI:4943387 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
regulation of type 2 immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ecm1 extracellular matrix protein 1 ISO MGI:MGI:4940879 (MGI:MGI:4887510|PMID:21217760) RGD PMID:21217760 MGI:MGI:4887510 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
T-helper 2 cell cytokine production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crlf2 cytokine receptor-like factor 2 ISO (MGI:MGI:3639613|PMID:16142237) RGD PMID:16142237 MGI:MGI:3639613 NCBI chr14:1,456,843...1,461,543
Ensembl chr14:1,456,844...1,461,543
JBrowse link
G Dennd1b DENN domain containing 1B ISO
IBA
(PMID:26774822)
PMID:21873635
(MGI:MGI:5751612|PMID:26774822)
RGD PMID:26774822, PMID:21873635 MGI:MGI:5751612, RGD:13792537 NCBI chr13:56,015,813...56,242,041
Ensembl chr13:56,015,901...56,236,677
JBrowse link
G Gba glucosylceramidase beta ISO (MGI:MGI:5429097|PMID:22665763) RGD PMID:22665763 MGI:MGI:5429097 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Il31ra interleukin 31 receptor A ISO MGI:MGI:3717594 (MGI:MGI:3844143|PMID:19414760) RGD PMID:19414760 MGI:MGI:3844143 NCBI chr 2:44,333,347...44,408,005
Ensembl chr 2:44,336,006...44,394,709
JBrowse link
G Il4 interleukin 4 ISO
IBA
(PMID:20554961)
PMID:21873635
RGD PMID:20554961, PMID:21873635 RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Stard7 StAR-related lipid transfer domain containing 7 ISO MGI:MGI:4433666 (MGI:MGI:5906122|PMID:25980009) RGD PMID:25980009 MGI:MGI:5906122 NCBI chr 3:119,698,655...119,727,303
Ensembl chr 3:119,698,652...119,727,347
JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:4456325|PMID:20421391), (MGI:MGI:5004732|PMID:21572431)
UniProt
RGD
PMID:20421391, PMID:21572431 GO_REF:0000024, MGI:MGI:4456325, MGI:MGI:5004732 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Bcl3 BCL3, transcription coactivator ISO MGI:MGI:2158443 (MGI:MGI:3621346|PMID:16081776) RGD PMID:16081776 MGI:MGI:3621346 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Gata3 GATA binding protein 3 ISO (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:4838368|PMID:20706986)
PMID:21873635
RGD PMID:20706986, PMID:21873635 MGI:MGI:4838368, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    response to stimulus 10570
      immune response 1749
        type 2 immune response 39
          T-helper 2 cell cytokine production + 16
          T-helper 2 cell differentiation + 16
          negative regulation of type 2 immune response + 14
          positive regulation of type 2 immune response + 15
          regulation of type 2 immune response + 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.