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ONTOLOGY REPORT - ANNOTATIONS


Term:heme metabolic process
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Accession:GO:0042168 term browser browse the term
Definition:The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
Synonyms:exact_synonym: haem metabolic process;   haem metabolism;   heme metabolism


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heme metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdh2 3-hydroxybutyrate dehydrogenase 2 JBrowse link 2 240,461,505 240,482,149 RGD:1600115
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1598930
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:1624291
RGD:13792537
G Slco1a6 solute carrier organic anion transporter family, member 1a6 JBrowse link 4 176,345,671 176,390,729 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1624291
heme A biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:1624291
G Cox15 cytochrome c oxidase assembly homolog COX15 JBrowse link 1 263,494,850 263,511,510 RGD:1624291
RGD:13792537
heme biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1599020
RGD:13792537
RGD:1624291
RGD:1600115
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:13792537
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1624291
RGD:13792537
RGD:1600115
G Atp5if1 ATP synthase inhibitory factor subunit 1 JBrowse link 5 150,719,570 150,723,287 RGD:1624291
RGD:13792537
RGD:1600115
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:13792537
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:1600961
RGD:1624291
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1600961
RGD:1624291
RGD:13792537
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:1600115
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:13792537
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
G Pgrmc1 progesterone receptor membrane component 1 JBrowse link X 123,205,869 123,213,880 RGD:1600115
RGD:1624291
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1600961
RGD:13792537
RGD:1624291
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
RGD:1600115
G Slc25a39 solute carrier family 25, member 39 JBrowse link 10 90,351,899 90,356,905 RGD:1600115
G Tmem14c transmembrane protein 14C JBrowse link 17 21,571,510 21,577,651 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:70052
RGD:13792537
RGD:1624291
RGD:2301379
G Uros uroporphyrinogen III synthase JBrowse link 1 205,755,766 205,778,170 RGD:1624291
RGD:13792537
heme catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blvra biliverdin reductase A JBrowse link 3 119,552,550 119,577,796 RGD:1600115
G Blvrb biliverdin reductase B JBrowse link 1 84,256,063 84,273,726 RGD:1624291
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1547877
RGD:13792537
RGD:1624291
G Hmox2 heme oxygenase 2 JBrowse link 10 10,990,034 11,035,493 RGD:13792537
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 JBrowse link 2 215,370,196 215,372,406 RGD:13792537
heme O biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 JBrowse link 10 50,439,778 50,563,920 RGD:1600115
heme oxidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
RGD:13792537
G Hmox2 heme oxygenase 2 JBrowse link 10 10,990,034 11,035,493 RGD:625638
RGD:13792537
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 JBrowse link 2 215,370,196 215,372,406 RGD:13792537
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1600115
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:1600115
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:1600115
G Cpox coproporphyrinogen oxidase JBrowse link 11 44,039,665 44,049,648 RGD:4145128
RGD:13792537
RGD:1600115
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:1600115
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:1624291
RGD:1600115
G Ppox protoporphyrinogen oxidase JBrowse link 13 89,650,094 89,654,998 RGD:1600115
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:1600115
regulation of heme biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Srrd SRR1 domain containing JBrowse link 12 50,315,876 50,321,488 RGD:1624291
RGD:1600115
G Tmem14c transmembrane protein 14C JBrowse link 17 21,571,510 21,577,651 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      pigment metabolic process 69
        heme metabolic process 29
          heme B metabolic process + 0
          heme C metabolic process + 0
          heme a metabolic process + 2
          heme biosynthetic process + 20
          heme catabolic process + 5
          heme o metabolic process + 1
          heme oxidation 3
          siroheme metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      cellular metabolic process 10737
        cellular aromatic compound metabolic process 5503
          tetrapyrrole metabolic process 46
            porphyrin-containing compound metabolic process 37
              heme metabolic process 29
                heme B metabolic process + 0
                heme C metabolic process + 0
                heme a metabolic process + 2
                heme biosynthetic process + 20
                heme catabolic process + 5
                heme o metabolic process + 1
                heme oxidation 3
                siroheme metabolic process + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.