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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-1 biosynthetic process
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Accession:GO:0042222 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen.
Synonyms:exact_synonym: IL-1 biosynthesis;   IL-1 biosynthetic process;   interleukin-1 anabolism;   interleukin-1 biosynthesis;   interleukin-1 formation;   interleukin-1 synthesis


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interleukin-1 beta biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1624291
RGD:1600115
positive regulation of interleukin-1 alpha biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:7488896
positive regulation of interleukin-1 beta biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1600115
RGD:1624291
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:1600115
RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1600115
RGD:1624291
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    multicellular organismal process 8585
      cytokine production 783
        cytokine biosynthetic process 116
          interleukin-1 biosynthetic process 8
            interleukin-1 alpha biosynthetic process + 1
            interleukin-1 beta biosynthetic process + 7
            negative regulation of interleukin-1 biosynthetic process + 0
            positive regulation of interleukin-1 biosynthetic process + 7
            regulation of interleukin-1 biosynthetic process + 7
Path 2
Term Annotations click to browse term
  biological_process 18008
    metabolic process 10729
      organic substance metabolic process 10177
        macromolecule metabolic process 8720
          protein metabolic process 5543
            cytokine metabolic process 120
              cytokine biosynthetic process 116
                interleukin-1 biosynthetic process 8
                  interleukin-1 alpha biosynthetic process + 1
                  interleukin-1 beta biosynthetic process + 7
                  negative regulation of interleukin-1 biosynthetic process + 0
                  positive regulation of interleukin-1 biosynthetic process + 7
                  regulation of interleukin-1 biosynthetic process + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.