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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


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natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07028902.1 RGD:1600115
G Cebpg CCAAT/enhancer binding protein gamma JBrowse link 1 91,286,956 91,297,459 RGD:1624291
RGD:1600115
G Gzmb granzyme B JBrowse link 15 35,413,862 35,417,293 RGD:1624291
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:1600115
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1624291
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:1600115
RGD:1624291
G Lyst lysosomal trafficking regulator JBrowse link 17 90,323,055 90,522,091 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G Prdx1 peroxiredoxin 1 JBrowse link 5 135,536,413 135,551,986 RGD:1624291
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:1624291
RGD:1600115
G Raet1e retinoic acid early transcript 1E JBrowse link 1 1,101,666 1,120,340 RGD:1624291
G Rnf19b ring finger protein 19B JBrowse link 5 147,246,032 147,270,892 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
G Ulbp1 UL16 binding protein 1 JBrowse link 1 1,181,301 1,200,526 RGD:1624291
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:1624291
RGD:1600115
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
G Clec12b C-type lectin domain family 12, member B JBrowse link 4 163,140,883 163,157,996 RGD:1624291
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:11568650
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:9685777
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:9685777
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313500
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1299590
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
RGD:1600115
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:2303778
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:1624291
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:1624291
G Klrb1c killer cell lectin like receptor B1C JBrowse link 4 162,528,614 162,553,421 RGD:1624291
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1600115
RGD:1624291
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:1600115
RGD:13792537
RGD:1624291
G Lag3 lymphocyte activating 3 JBrowse link 4 157,425,644 157,433,700 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:1624291
G Ly49s3 Ly-49 stimulatory receptor 3 RGD:633264
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link 20 5,170,169 5,175,773 RGD:1624291
RGD:13792537
RGD:1600115
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
G Raet1e retinoic acid early transcript 1E JBrowse link 1 1,101,666 1,120,340 RGD:1624291
G Raet1l retinoic acid early transcript 1L JBrowse link 7 114,233,896 114,234,243 RGD:9685184
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Rrlt similar to retinoic acid early transcript 1L JBrowse link 1 1,437,716 1,442,089 RGD:9685184
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 JBrowse link 20 1,814,661 1,833,033 RGD:1600115
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1a SH2 domain containing 1A JBrowse link X 128,897,053 128,925,408 RGD:1624291
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:1624291
RGD:1600115
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07032888.1 RGD:13792537
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
RGD:13792537
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
RGD:13792537
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:9685180
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:13792537
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
G Rrlt similar to retinoic acid early transcript 1L JBrowse link 1 1,437,716 1,442,089 RGD:9685180
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec2d C-type lectin domain family 2, member D JBrowse link 4 162,278,252 162,302,881 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A JBrowse link 13 27,153,500 27,159,319 RGD:1624291
G Serpinb9 serpin family B member 9 JBrowse link 17 32,648,846 32,673,047 RGD:1624291
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:2312378
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:2312378
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 JBrowse link 10 55,085,269 55,135,069 RGD:1624291
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
RGD:13792537
RGD:1600115
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:13792537
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
G Ulbp1 UL16 binding protein 1 JBrowse link 1 1,181,301 1,200,526 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      cell killing 227
        leukocyte mediated cytotoxicity 136
          natural killer cell mediated cytotoxicity 67
            natural killer cell degranulation + 11
            natural killer cell mediated cytotoxicity directed against tumor cell target + 12
            negative regulation of natural killer cell mediated cytotoxicity + 20
            positive regulation of natural killer cell mediated cytotoxicity + 35
            regulation of natural killer cell mediated cytotoxicity + 53
Path 2
Term Annotations click to browse term
  biological_process 19578
    response to stimulus 10490
      response to external stimulus 3136
        response to external biotic stimulus 1618
          response to other organism 1614
            defense response to other organism 1027
              innate immune response 733
                natural killer cell mediated immunity 71
                  natural killer cell mediated cytotoxicity 67
                    natural killer cell degranulation + 11
                    natural killer cell mediated cytotoxicity directed against tumor cell target + 12
                    negative regulation of natural killer cell mediated cytotoxicity + 20
                    positive regulation of natural killer cell mediated cytotoxicity + 35
                    regulation of natural killer cell mediated cytotoxicity + 53
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.