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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


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natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CEBPG CCAAT enhancer binding protein gamma JBrowse link 19 39,039,837 39,049,671 RGD:9068941
G CLEC2A C-type lectin domain family 2 member A JBrowse link 12 10,195,632 10,229,273 RGD:9068941
G GZMB granzyme B JBrowse link 14 23,523,619 23,526,931 RGD:9068941
G IL18 interleukin 18 JBrowse link 11 110,867,586 110,888,371 RGD:9068941
G LOC100986963 UL16-binding protein 1 JBrowse link 6 152,477,350 152,486,911 RGD:9068941
G LOC100988536 UL-16 binding protein 5 JBrowse link 6 152,424,796 152,431,160 RGD:9068941
G LOC100989567 NKG2-D type II integral membrane protein JBrowse link 12 10,662,424 10,699,078 RGD:9068941
G LYST lysosomal trafficking regulator JBrowse link 1 216,231,824 216,436,293 RGD:9068941
G PRDX1 peroxiredoxin 1 JBrowse link 1 46,171,453 46,182,018 RGD:9068941
G PTPN6 protein tyrosine phosphatase non-receptor type 6 JBrowse link 12 6,991,099 7,008,830 RGD:9068941
G RAET1E retinoic acid early transcript 1E JBrowse link 6 152,400,887 152,413,620 RGD:9068941
G SLAMF7 SLAM family member 7 JBrowse link 1 140,017,185 140,033,105 RGD:9068941
G TUBB tubulin beta class I JBrowse link 6 31,333,985 31,339,739 RGD:9068941
G TUBB4B tubulin beta 4B class IVb JBrowse link 9 137,269,849 137,271,758 RGD:9068941
G ULBP3 UL16 binding protein 3 JBrowse link 6 152,581,661 152,588,430 RGD:9068941
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CORO1A coronin 1A JBrowse link 16 30,549,880 30,555,093 RGD:9068941
G KLRF2 killer cell lectin like receptor F2 JBrowse link 12 10,178,501 10,192,800 RGD:9068941
G RAB27A RAB27A, member RAS oncogene family JBrowse link 15 52,498,202 52,584,731 RGD:9068941
G UNC13D unc-13 homolog D JBrowse link 17 75,327,849 75,345,282 RGD:9068941
G VAMP2 vesicle associated membrane protein 2 JBrowse link 17 48,228,253 48,231,948 RGD:9068941
G VAMP7 vesicle associated membrane protein 7 JBrowse link X 155,257,593 155,320,215 RGD:9068941
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 17 4,757,048 4,767,517 RGD:9068941
G CLEC12B C-type lectin domain family 12 member B JBrowse link 12 10,304,810 10,312,863 RGD:9068941
G CRK CRK proto-oncogene, adaptor protein JBrowse link 17 1,304,309 1,336,698 RGD:9068941
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CEACAM1 CEA cell adhesion molecule 1 JBrowse link 19 47,987,522 48,008,739 RGD:9068941
G HAVCR2 hepatitis A virus cellular receptor 2 JBrowse link 5 159,107,938 159,134,973 RGD:9068941
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AP1G1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 16 71,568,856 71,648,744 RGD:9068941
G CD160 CD160 molecule JBrowse link 1 113,636,195 113,644,493 RGD:9068941
G LAMP1 lysosomal associated membrane protein 1 JBrowse link 13 113,507,400 113,530,179 RGD:9068941
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AP1G1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 16 71,568,856 71,648,744 RGD:9068941
G CADM1 cell adhesion molecule 1 JBrowse link 11 113,950,291 114,280,453 RGD:9068941
G CD160 CD160 molecule JBrowse link 1 113,636,195 113,644,493 RGD:9068941
G CD226 CD226 molecule JBrowse link 18 66,533,949 66,627,580 RGD:9068941
G CRTAM cytotoxic and regulatory T cell molecule JBrowse link 11 121,591,738 121,625,744 RGD:9068941
G IL12A interleukin 12A JBrowse link 3 165,061,505 165,068,666 RGD:9068941
G IL18RAP interleukin 18 receptor accessory protein JBrowse link 2A 103,510,109 103,543,950 RGD:9068941
G IL21 interleukin 21 JBrowse link 4 125,940,979 125,951,915 RGD:9068941
G LAG3 lymphocyte activating 3 JBrowse link 12 6,817,143 6,823,112 RGD:9068941
G LAMP1 lysosomal associated membrane protein 1 JBrowse link 13 113,507,400 113,530,179 RGD:9068941
G LOC100989567 NKG2-D type II integral membrane protein JBrowse link 12 10,662,424 10,699,078 RGD:9068941
G NCR3 natural cytotoxicity triggering receptor 3 JBrowse link 6 32,139,981 32,171,525 RGD:9068941
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 50,399,367 50,443,024 RGD:9068941
G PVR PVR cell adhesion molecule JBrowse link 19 50,196,980 50,216,832 RGD:9068941
G RAET1E retinoic acid early transcript 1E JBrowse link 6 152,400,887 152,413,620 RGD:9068941
G RASGRP1 RAS guanyl releasing protein 1 JBrowse link 15 35,672,893 35,749,621 RGD:9068941
G SH2D1A SH2 domain containing 1A JBrowse link X 123,712,932 123,739,424 RGD:9068941
G SLAMF6 SLAM family member 6 JBrowse link 1 139,761,121 139,799,348 RGD:9068941
G STAT5B signal transducer and activator of transcription 5B JBrowse link 17 15,306,412 15,338,973 RGD:9068941
G VAV1 vav guanine nucleotide exchange factor 1 JBrowse link 19 6,726,578 6,832,795 RGD:9068941
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD226 CD226 molecule JBrowse link 18 66,533,949 66,627,580 RGD:9068941
G CRTAM cytotoxic and regulatory T cell molecule JBrowse link 11 121,591,738 121,625,744 RGD:9068941
G IL12A interleukin 12A JBrowse link 3 165,061,505 165,068,666 RGD:9068941
G IL12B interleukin 12B JBrowse link 5 161,323,402 161,339,051 RGD:9068941
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 50,399,367 50,443,024 RGD:9068941
G PVR PVR cell adhesion molecule JBrowse link 19 50,196,980 50,216,832 RGD:9068941
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SERPINB4 serpin family B member 4 JBrowse link 18 60,308,357 60,312,884 RGD:9068941
G SERPINB9 serpin family B member 9 JBrowse link 6 2,812,815 2,827,991 RGD:9068941
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LEP leptin JBrowse link 7 132,884,994 132,901,519 RGD:9068941
G NCR1 natural cytotoxicity triggering receptor 1 JBrowse link 19 60,645,677 60,652,274 RGD:9068941
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 JBrowse link 17 47,518,629 47,585,160 RGD:9068941
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CADM1 cell adhesion molecule 1 JBrowse link 11 113,950,291 114,280,453 RGD:9068941
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 50,399,367 50,443,024 RGD:9068941
G PVR PVR cell adhesion molecule JBrowse link 19 50,196,980 50,216,832 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15758
    cellular process 15087
      cell killing 181
        leukocyte mediated cytotoxicity 99
          natural killer cell mediated cytotoxicity 50
            natural killer cell degranulation + 9
            natural killer cell mediated cytotoxicity directed against tumor cell target + 8
            negative regulation of natural killer cell mediated cytotoxicity + 7
            positive regulation of natural killer cell mediated cytotoxicity + 21
            regulation of natural killer cell mediated cytotoxicity + 31
Path 2
Term Annotations click to browse term
  biological_process 15758
    response to stimulus 8304
      response to external stimulus 2633
        response to external biotic stimulus 1321
          response to other organism 1319
            defense response to other organism 987
              innate immune response 792
                natural killer cell mediated immunity 55
                  natural killer cell mediated cytotoxicity 50
                    natural killer cell degranulation + 9
                    natural killer cell mediated cytotoxicity directed against tumor cell target + 8
                    negative regulation of natural killer cell mediated cytotoxicity + 7
                    positive regulation of natural killer cell mediated cytotoxicity + 21
                    regulation of natural killer cell mediated cytotoxicity + 31
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.