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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


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natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cebpg CCAAT enhancer binding protein gamma JBrowse link NW_004955468 3,137,106 3,141,733 RGD:9068941
G Il18 interleukin 18 JBrowse link NW_004955412 13,807,361 13,826,007 RGD:9068941
G LOC102005691 NKG2-D type II integral membrane protein JBrowse link NW_004955413 7,489,158 7,503,014 RGD:9068941
G Lyst lysosomal trafficking regulator JBrowse link NW_004955492 4,161,976 4,371,637 RGD:9068941
G Prdx1 peroxiredoxin 1 JBrowse link NW_004955464 12,761,390 12,773,413 RGD:9068941
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 JBrowse link NW_004955413 4,525,954 4,547,177 RGD:9068941
G Raet1e retinoic acid early transcript 1E JBrowse link NW_004955439 11,413,978 11,420,902 RGD:9068941
G Slamf7 SLAM family member 7 JBrowse link NW_004955468 12,440,157 12,457,445 RGD:9068941
G Tubb tubulin beta class I JBrowse link NW_004955583 704,811 715,742 RGD:9068941
G Tubb4b tubulin beta 4B class IVb JBrowse link NW_004955513 5,237,050 5,239,370 RGD:9068941
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin 1A JBrowse link NW_004955493 6,815,148 6,820,295 RGD:9068941
G Rab27a RAB27A, member RAS oncogene family JBrowse link NW_004955409 588,725 621,874 RGD:9068941
G Unc13d unc-13 homolog D JBrowse link NW_004955506 6,407,073 6,423,406 RGD:9068941
G Vamp2 vesicle associated membrane protein 2 JBrowse link NW_004955467 8,793,296 8,796,771 RGD:9068941
G Vamp7 vesicle associated membrane protein 7 JBrowse link NW_004955594 20,496 72,648 RGD:9068941
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin beta 2 JBrowse link NW_004955467 10,109,985 10,118,687 RGD:9068941
G Clec12b C-type lectin domain family 12 member B JBrowse link NW_004955413 7,842,994 7,852,685 RGD:9068941
G Crk CRK proto-oncogene, adaptor protein JBrowse link NW_004955481 1,705,595 1,748,363 RGD:9068941
G Lgals9 galectin 9 JBrowse link NW_004955481 5,234,125 5,249,564 RGD:9068941
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link NW_004955555 426,894 446,235 RGD:9068941
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link NW_004955408 11,289,920 11,311,216 RGD:9068941
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link NW_004955484 4,430,461 4,511,368 RGD:9068941
G Cd160 CD160 molecule JBrowse link NW_004955568 365,700 372,149 RGD:9068941
G Lamp1 lysosomal associated membrane protein 1 JBrowse link NW_004955404 557,090 573,532 RGD:9068941
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link NW_004955484 4,430,461 4,511,368 RGD:9068941
G Cadm1 cell adhesion molecule 1 JBrowse link NW_004955412 16,673,401 17,005,082 RGD:9068941
G Cd160 CD160 molecule JBrowse link NW_004955568 365,700 372,149 RGD:9068941
G Cd226 CD226 molecule JBrowse link NW_004955402 53,408,861 53,560,896 RGD:9068941
G Crtam cytotoxic and regulatory T cell molecule JBrowse link NW_004955412 23,676,171 23,706,250 RGD:9068941
G Il12a interleukin 12A JBrowse link NW_004955448 10,611,131 10,617,911 RGD:9068941
G Il18rap interleukin 18 receptor accessory protein JBrowse link NW_004955470 7,894,900 7,923,653 RGD:9068941
G Il21 interleukin 21 JBrowse link NW_004955428 18,057,096 18,065,492 RGD:9068941
G Lag3 lymphocyte activating 3 JBrowse link NW_004955413 4,379,529 4,385,456 RGD:9068941
G Lamp1 lysosomal associated membrane protein 1 JBrowse link NW_004955404 557,090 573,532 RGD:9068941
G LOC102005691 NKG2-D type II integral membrane protein JBrowse link NW_004955413 7,489,158 7,503,014 RGD:9068941
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link NW_004955437 130,360 134,751 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004955555 1,959,702 1,985,679 RGD:9068941
G Raet1e retinoic acid early transcript 1E JBrowse link NW_004955439 11,413,978 11,420,902 RGD:9068941
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link NW_004955416 5,494,030 5,561,608 RGD:9068941
G Sh2d1a SH2 domain containing 1A JBrowse link NW_004955473 10,345,407 10,370,535 RGD:9068941
G Slamf6 SLAM family member 6 JBrowse link NW_004955468 12,233,629 12,264,502 RGD:9068941
G Stat5b signal transducer and activator of transcription 5B JBrowse link NW_004955451 16,253,645 16,295,337 RGD:9068941
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link NW_004955495 2,697,508 2,755,468 RGD:9068941
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd226 CD226 molecule JBrowse link NW_004955402 53,408,861 53,560,896 RGD:9068941
G Crtam cytotoxic and regulatory T cell molecule JBrowse link NW_004955412 23,676,171 23,706,250 RGD:9068941
G Il12a interleukin 12A JBrowse link NW_004955448 10,611,131 10,617,911 RGD:9068941
G Il12b interleukin 12B JBrowse link NW_004955408 13,302,506 13,316,300 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004955555 1,959,702 1,985,679 RGD:9068941
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link NW_004955479 9,266,604 9,276,568 RGD:9068941
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 JBrowse link NW_004955467 8,104,242 8,157,637 RGD:9068941
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link NW_004955412 16,673,401 17,005,082 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004955555 1,959,702 1,985,679 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    cellular process 14021
      cell killing 138
        leukocyte mediated cytotoxicity 80
          natural killer cell mediated cytotoxicity 41
            natural killer cell degranulation + 8
            natural killer cell mediated cytotoxicity directed against tumor cell target + 7
            negative regulation of natural killer cell mediated cytotoxicity + 6
            positive regulation of natural killer cell mediated cytotoxicity + 20
            regulation of natural killer cell mediated cytotoxicity + 28
Path 2
Term Annotations click to browse term
  biological_process 14616
    response to stimulus 7743
      response to external stimulus 2434
        response to external biotic stimulus 1154
          response to other organism 1152
            defense response to other organism 835
              innate immune response 669
                natural killer cell mediated immunity 44
                  natural killer cell mediated cytotoxicity 41
                    natural killer cell degranulation + 8
                    natural killer cell mediated cytotoxicity directed against tumor cell target + 7
                    negative regulation of natural killer cell mediated cytotoxicity + 6
                    positive regulation of natural killer cell mediated cytotoxicity + 20
                    regulation of natural killer cell mediated cytotoxicity + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.