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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


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natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CEBPG CCAAT enhancer binding protein gamma JBrowse link 19 33,373,709 33,382,686 RGD:2290271
G CLEC2A C-type lectin domain family 2 member A JBrowse link 12 9,882,733 9,932,430 RGD:2290271
G GZMB granzyme B JBrowse link 14 24,630,954 24,634,190 RGD:2290271
G IL18 interleukin 18 JBrowse link 11 112,143,251 112,164,104 RGD:2290271
G KIR3DL1 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 JBrowse link 19 54,816,438 54,830,778 RGD:2290271
G KLRC4-KLRK1 KLRC4-KLRK1 readthrough JBrowse link 12 10,372,353 10,410,146 RGD:2290271
G KLRK1 killer cell lectin like receptor K1 JBrowse link 12 10,372,353 10,390,041 RGD:2290271
G LYST lysosomal trafficking regulator JBrowse link 1 235,661,031 235,883,713 RGD:2290271
G MICA MHC class I polypeptide-related sequence A JBrowse link 6 31,400,711 31,415,315 RGD:2290271
G PRDX1 peroxiredoxin 1 JBrowse link 1 45,511,035 45,522,890 RGD:2290271
G PTPN6 protein tyrosine phosphatase non-receptor type 6 JBrowse link 12 6,946,577 6,961,316 RGD:2290271
G RAET1E retinoic acid early transcript 1E JBrowse link 6 149,864,399 149,898,353 RGD:2290271
G RAET1G retinoic acid early transcript 1G JBrowse link 6 149,916,878 149,923,133 RGD:2290271
G SLAMF7 SLAM family member 7 JBrowse link 1 160,739,057 160,754,821 RGD:2290271
G TUBB tubulin beta class I JBrowse link 6 30,720,352 30,725,422 RGD:2290271
G TUBB4B tubulin beta 4B class IVb JBrowse link 9 137,241,287 137,243,707 RGD:2290271
G ULBP1 UL16 binding protein 1 JBrowse link 6 149,963,943 149,973,715 RGD:2290271
G ULBP2 UL16 binding protein 2 JBrowse link 6 149,941,947 149,949,235 RGD:2290271
G ULBP3 UL16 binding protein 3 JBrowse link 6 150,061,053 150,069,121 RGD:2290271
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CORO1A coronin 1A JBrowse link 16 30,183,410 30,189,076 RGD:2290271
G KLRF2 killer cell lectin like receptor F2 JBrowse link 12 9,881,489 9,895,833 RGD:2290271
G RAB27A RAB27A, member RAS oncogene family JBrowse link 15 55,202,966 55,291,338 RGD:2290271
G UNC13D unc-13 homolog D JBrowse link 17 75,827,225 75,844,404 RGD:2290271
G VAMP2 vesicle associated membrane protein 2 JBrowse link 17 8,159,147 8,162,948 RGD:2290271
G VAMP7 vesicle associated membrane protein 7 JBrowse link X
Y
155,881,318
57,067,838
155,943,769
57,130,289
RGD:2290271
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HLA-F major histocompatibility complex, class I, F JBrowse link 6 29,723,340 29,740,355 RGD:2290271
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 17 4,710,619 4,721,500 RGD:2290271
G CLEC12B C-type lectin domain family 12 member B JBrowse link 12 10,006,138 10,018,800 RGD:2290271
G CRK CRK proto-oncogene, adaptor protein JBrowse link 17 1,420,693 1,456,232 RGD:2290271
G HLA-E major histocompatibility complex, class I, E JBrowse link 6 30,489,508 30,494,194 RGD:2290271
G HLA-F major histocompatibility complex, class I, F JBrowse link 6 29,723,340 29,740,355 RGD:2290271
G HLA-G major histocompatibility complex, class I, G JBrowse link 6 29,826,979 29,831,130 RGD:2290271
G KIR2DL4 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 JBrowse link 19 54,803,610 54,814,517 RGD:2290271
G LGALS9 galectin 9 JBrowse link 17 27,631,172 27,649,560 RGD:2290271
G LILRB1 leukocyte immunoglobulin like receptor B1 JBrowse link 19 54,616,930 54,637,925 RGD:2290271
G MICA MHC class I polypeptide-related sequence A JBrowse link 6 31,400,711 31,415,315 RGD:2290271
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CEACAM1 CEA cell adhesion molecule 1 JBrowse link 19 42,507,306 42,528,482 RGD:2290271
G HAVCR2 hepatitis A virus cellular receptor 2 JBrowse link 5 157,085,832 157,109,044 RGD:2290271
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AP1G1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 16 71,729,000 71,808,834 RGD:2290271
G CD160 CD160 molecule JBrowse link 1 145,719,312 145,739,288 RGD:2290271
G HLA-F major histocompatibility complex, class I, F JBrowse link 6 29,723,340 29,740,355 RGD:2290271
G LAMP1 lysosomal associated membrane protein 1 JBrowse link 13 113,297,239 113,323,672 RGD:2290271
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AP1G1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 16 71,729,000 71,808,834 RGD:2290271
G CADM1 cell adhesion molecule 1 JBrowse link 11 115,169,236 115,504,428 RGD:2290271
G CD160 CD160 molecule JBrowse link 1 145,719,312 145,739,288 RGD:2290271
G CD226 CD226 molecule JBrowse link 18 69,853,274 69,962,086 RGD:2290271
G CRTAM cytotoxic and regulatory T cell molecule JBrowse link 11 122,838,419 122,872,643 RGD:2290271
G HLA-E major histocompatibility complex, class I, E JBrowse link 6 30,489,508 30,494,194 RGD:2290271
G IL12A interleukin 12A JBrowse link 3 159,988,835 159,996,019 RGD:2290271
G IL18RAP interleukin 18 receptor accessory protein JBrowse link 2 102,418,550 102,452,568 RGD:2290271
G IL21 interleukin 21 JBrowse link 4 122,610,108 122,621,066 RGD:2290271
G KLRC4-KLRK1 KLRC4-KLRK1 readthrough JBrowse link 12 10,372,353 10,410,146 RGD:2290271
G KLRK1 killer cell lectin like receptor K1 JBrowse link 12 10,372,353 10,390,041 RGD:2290271
G LAG3 lymphocyte activating 3 JBrowse link 12 6,772,483 6,778,455 RGD:2290271
G LAMP1 lysosomal associated membrane protein 1 JBrowse link 13 113,297,239 113,323,672 RGD:2290271
G NCR3 natural cytotoxicity triggering receptor 3 JBrowse link 6 31,588,895 31,593,024 RGD:2290271
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 44,846,297 44,889,223 RGD:2290271
G PVR PVR cell adhesion molecule JBrowse link 19 44,643,798 44,666,162 RGD:2290271
G RAET1E retinoic acid early transcript 1E JBrowse link 6 149,864,399 149,898,353 RGD:2290271
G RASGRP1 RAS guanyl releasing protein 1 JBrowse link 15 38,488,097 38,564,814 RGD:2290271
G SH2D1A SH2 domain containing 1A JBrowse link X 124,346,282 124,373,160 RGD:2290271
G SLAMF6 SLAM family member 6 JBrowse link 1 160,485,030 160,523,263 RGD:2290271
G STAT5B signal transducer and activator of transcription 5B JBrowse link 17 42,199,177 42,288,437 RGD:2290271
G VAV1 vav guanine nucleotide exchange factor 1 JBrowse link 19 6,772,708 6,857,366 RGD:2290271
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD226 CD226 molecule JBrowse link 18 69,853,274 69,962,086 RGD:2290271
G CRTAM cytotoxic and regulatory T cell molecule JBrowse link 11 122,838,419 122,872,643 RGD:2290271
G IL12A interleukin 12A JBrowse link 3 159,988,835 159,996,019 RGD:2290271
G IL12B interleukin 12B JBrowse link 5 159,314,780 159,330,487 RGD:2290271
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 44,846,297 44,889,223 RGD:2290271
G PVR PVR cell adhesion molecule JBrowse link 19 44,643,798 44,666,162 RGD:2290271
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HLA-A major histocompatibility complex, class I, A JBrowse link 6 29,942,532 29,945,870 RGD:2290271
G HLA-B major histocompatibility complex, class I, B JBrowse link 6 31,353,875 31,357,179 RGD:2290271
G HLA-E major histocompatibility complex, class I, E JBrowse link 6 30,489,508 30,494,194 RGD:2290271
G HLA-G major histocompatibility complex, class I, G JBrowse link 6 29,826,979 29,831,130 RGD:2290271
G SERPINB4 serpin family B member 4 JBrowse link 18 63,637,259 63,644,310 RGD:2290271
G SERPINB9 serpin family B member 9 JBrowse link 6 2,887,270 2,903,318 RGD:2290271
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LEP leptin JBrowse link 7 128,241,201 128,257,629 RGD:2290271
G NCR1 natural cytotoxicity triggering receptor 1 JBrowse link 19 54,906,063 54,938,211 RGD:2290271
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 JBrowse link 17 8,802,722 8,870,003 RGD:2290271
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CADM1 cell adhesion molecule 1 JBrowse link 11 115,169,236 115,504,428 RGD:2290271
G NECTIN2 nectin cell adhesion molecule 2 JBrowse link 19 44,846,297 44,889,223 RGD:2290271
G PVR PVR cell adhesion molecule JBrowse link 19 44,643,798 44,666,162 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18104
    cellular process 17121
      cell killing 213
        leukocyte mediated cytotoxicity 113
          natural killer cell mediated cytotoxicity 62
            natural killer cell degranulation + 10
            natural killer cell mediated cytotoxicity directed against tumor cell target + 8
            negative regulation of natural killer cell mediated cytotoxicity + 16
            positive regulation of natural killer cell mediated cytotoxicity + 24
            regulation of natural killer cell mediated cytotoxicity + 41
Path 2
Term Annotations click to browse term
  biological_process 18104
    response to stimulus 9452
      response to external stimulus 2959
        response to external biotic stimulus 1593
          response to other organism 1591
            defense response to other organism 1218
              innate immune response 997
                natural killer cell mediated immunity 67
                  natural killer cell mediated cytotoxicity 62
                    natural killer cell degranulation + 10
                    natural killer cell mediated cytotoxicity directed against tumor cell target + 8
                    negative regulation of natural killer cell mediated cytotoxicity + 16
                    positive regulation of natural killer cell mediated cytotoxicity + 24
                    regulation of natural killer cell mediated cytotoxicity + 41
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.