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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


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natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cebpg CCAAT/enhancer binding protein (C/EBP), gamma JBrowse link 7 35,046,422 35,056,566 RGD:2290270
G H60b histocompatibility 60b JBrowse link 10 22,273,474 22,288,849 RGD:2290270
G H60c histocompatibility 60c JBrowse link 10 3,256,202 3,268,091 RGD:2290270
G Il18 interleukin 18 JBrowse link 9 50,554,700 50,581,841 RGD:2290270
G Lyst lysosomal trafficking regulator JBrowse link 13 13,590,311 13,778,803 RGD:2290270
G Prdx1 peroxiredoxin 1 JBrowse link 4 116,685,599 116,700,000 RGD:2290270
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 6 124,720,707 124,738,709 RGD:2290270
G Raet1d retinoic acid early transcript delta JBrowse link 10 22,361,861 22,374,143 RGD:2290270
G Rnf19b ring finger protein 19B JBrowse link 4 129,058,144 129,084,526 RGD:2290270
G Stx11 syntaxin 11 JBrowse link 10 12,938,217 12,964,498 RGD:2290270
G Ulbp1 UL16 binding protein 1 JBrowse link 10 7,444,873 7,473,641 RGD:2290270
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin, actin binding protein 1A JBrowse link 7 126,699,774 126,704,816 RGD:2290270
G Rab27a RAB27A, member RAS oncogene family JBrowse link 9 73,044,810 73,097,623 RGD:2290270
G Stx11 syntaxin 11 JBrowse link 10 12,938,217 12,964,498 RGD:2290270
G Unc13d unc-13 homolog D JBrowse link 11 116,062,095 116,078,495 RGD:2290270
G Vamp7 vesicle-associated membrane protein 7 RGD:2290270
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 lectin, galactose binding, soluble 9 JBrowse link 11 78,962,979 78,984,924 RGD:2290270
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 11 70,432,485 70,440,828 RGD:2290270
G Clec12b C-type lectin domain family 12, member B JBrowse link 6 129,375,513 129,427,634 RGD:2290270
G Crk v-crk avian sarcoma virus CT10 oncogene homolog JBrowse link 11 75,679,194 75,708,428 RGD:2290270
G Gfer growth factor, augmenter of liver regeneration JBrowse link 17 24,693,189 24,697,159 RGD:2290270
G H2-M3 histocompatibility 2, M region locus 3 JBrowse link 17 37,270,234 37,274,485 RGD:2290270
G H2-T23 histocompatibility 2, T region locus 23 JBrowse link 17 36,029,977 36,032,701 RGD:2290270
G Igf2 insulin-like growth factor 2 JBrowse link 7 142,650,768 142,666,816 RGD:2290270
G Klrb1b killer cell lectin-like receptor subfamily B member 1B JBrowse link 6 128,813,706 128,826,315 RGD:2290270
G Sh2d1b1 SH2 domain containing 1B1 JBrowse link 1 170,277,318 170,286,769 RGD:2290270
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 1 170,232,871 170,251,587 RGD:2290270
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 JBrowse link 7 25,461,702 25,477,647 RGD:2290270
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 11 46,454,931 46,481,255 RGD:2290270
G Klre1 killer cell lectin-like receptor family E member 1 JBrowse link 6 129,559,365 129,585,828 RGD:2290270
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor protein complex AP-1, gamma 1 subunit JBrowse link 8 109,778,583 109,864,210 RGD:2290270
G Cd160 CD160 antigen JBrowse link 3 96,798,763 96,829,351 RGD:2290270
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 8 13,159,161 13,175,338 RGD:2290270
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor protein complex AP-1, gamma 1 subunit JBrowse link 8 109,778,583 109,864,210 RGD:2290270
G Cadm1 cell adhesion molecule 1 JBrowse link 9 47,530,170 47,862,280 RGD:2290270
G Cd160 CD160 antigen JBrowse link 3 96,798,763 96,829,351 RGD:2290270
G Cd226 CD226 antigen JBrowse link 18 89,176,954 89,272,232 RGD:2290270
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 9 40,972,798 41,004,628 RGD:2290270
G H2-M3 histocompatibility 2, M region locus 3 JBrowse link 17 37,270,234 37,274,485 RGD:2290270
G H2-T23 histocompatibility 2, T region locus 23 JBrowse link 17 36,029,977 36,032,701 RGD:2290270
G Il12a interleukin 12a JBrowse link 3 68,690,644 68,698,550 RGD:2290270
G Il18rap interleukin 18 receptor accessory protein JBrowse link 1 40,515,362 40,551,707 RGD:2290270
G Il21 interleukin 21 JBrowse link 3 37,222,759 37,232,636 RGD:2290270
G Klrb1c killer cell lectin-like receptor subfamily B member 1C JBrowse link 6 128,778,485 128,788,641 RGD:2290270
G Klre1 killer cell lectin-like receptor family E member 1 JBrowse link 6 129,559,365 129,585,828 RGD:2290270
G Klrk1 killer cell lectin-like receptor subfamily K, member 1 JBrowse link 6 129,610,323 129,623,903 RGD:2290270
G Lag3 lymphocyte-activation gene 3 JBrowse link 6 124,904,359 124,912,434 RGD:2290270
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 8 13,159,161 13,175,338 RGD:2290270
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 7 19,716,644 19,749,573 RGD:2290270
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 2 117,279,983 117,342,877 RGD:2290270
G Sh2d1a SH2 domain containing 1A JBrowse link X 42,502,565 42,522,097 RGD:2290270
G Sh2d1b1 SH2 domain containing 1B1 JBrowse link 1 170,277,318 170,286,769 RGD:2290270
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 1 170,232,871 170,251,587 RGD:2290270
G Slamf6 SLAM family member 6 JBrowse link 1 171,917,458 171,948,958 RGD:2290270
G Stat5a signal transducer and activator of transcription 5A JBrowse link 11 100,859,351 100,885,169 RGD:2290270
G Stat5b signal transducer and activator of transcription 5B JBrowse link 11 100,780,731 100,859,004 RGD:2290270
G Vav1 vav 1 oncogene JBrowse link 17 57,279,100 57,329,236 RGD:2290270
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd226 CD226 antigen JBrowse link 18 89,176,954 89,272,232 RGD:2290270
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 9 40,972,798 41,004,628 RGD:2290270
G Il12a interleukin 12a JBrowse link 3 68,690,644 68,698,550 RGD:2290270
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:2290270
G Klrk1 killer cell lectin-like receptor subfamily K, member 1 JBrowse link 6 129,610,323 129,623,903 RGD:2290270
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 7 19,716,644 19,749,573 RGD:2290270
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec2d C-type lectin domain family 2, member d JBrowse link 6 129,180,615 129,186,535 RGD:2290270
G H2-M3 histocompatibility 2, M region locus 3 JBrowse link 17 37,270,234 37,274,485 RGD:2290270
G H2-T23 histocompatibility 2, T region locus 23 JBrowse link 17 36,029,977 36,032,701 RGD:2290270
G Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A JBrowse link 1 107,045,587 107,052,303 RGD:2290270
G Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 JBrowse link 13 32,997,061 33,017,955 RGD:2290270
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) JBrowse link 17 34,187,556 34,197,225 RGD:2290270
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) JBrowse link 17 34,204,479 34,216,321 RGD:2290270
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:2290270
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 11 68,503,019 68,552,698 RGD:2290270
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link 9 47,530,170 47,862,280 RGD:2290270
G H60a histocompatibility 60a RGD:2290270
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 7 19,716,644 19,749,573 RGD:2290270
G Raet1b retinoic acid early transcript beta RGD:2290270
G Ulbp1 UL16 binding protein 1 JBrowse link 10 7,444,873 7,473,641 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23155
    cellular process 16951
      cell killing 200
        leukocyte mediated cytotoxicity 142
          natural killer cell mediated cytotoxicity 58
            natural killer cell degranulation + 9
            natural killer cell mediated cytotoxicity directed against tumor cell target + 9
            negative regulation of natural killer cell mediated cytotoxicity + 19
            positive regulation of natural killer cell mediated cytotoxicity + 28
            regulation of natural killer cell mediated cytotoxicity + 44
Path 2
Term Annotations click to browse term
  biological_process 23155
    response to stimulus 9761
      response to external stimulus 2847
        response to external biotic stimulus 1558
          response to other organism 1556
            defense response to other organism 1099
              innate immune response 830
                natural killer cell mediated immunity 61
                  natural killer cell mediated cytotoxicity 58
                    natural killer cell degranulation + 9
                    natural killer cell mediated cytotoxicity directed against tumor cell target + 9
                    negative regulation of natural killer cell mediated cytotoxicity + 19
                    positive regulation of natural killer cell mediated cytotoxicity + 28
                    regulation of natural killer cell mediated cytotoxicity + 44
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.