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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity
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Accession:GO:0042267 term browser browse the term
Definition:The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cell death;   NK cell mediated cell killing;   NK cell mediated cytotoxicity;   natural killer cell mediated cell death;   natural killer cell mediated cell killing
 related_synonym: NK cell mediated cytolysis;   killer activity;   natural killer cell mediated cytolysis


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natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cebpg CCAAT enhancer binding protein gamma JBrowse link NW_004936570 2,435,672 2,439,056 RGD:9068941
G Clec2a C-type lectin domain family 2 member A JBrowse link NW_004936902 583,850 586,981 RGD:9068941
G Il18 interleukin 18 JBrowse link NW_004936612 2,306,963 2,325,086 RGD:9068941
G LOC101976242 NKG2-D type II integral membrane protein JBrowse link NW_004936902 216,495 229,150 RGD:9068941
G Lyst lysosomal trafficking regulator JBrowse link NW_004936484 16,750,976 16,915,999 RGD:9068941
G Prdx1 peroxiredoxin 1 JBrowse link NW_004936474 26,641,776 26,653,291 RGD:9068941
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 JBrowse link NW_004936709 864,206 884,630 RGD:9068941
G Tubb tubulin beta class I JBrowse link NW_004936837 380,880 384,752 RGD:9068941
G Tubb4b tubulin beta 4B class IVb JBrowse link NW_004936669 749,203 751,622 RGD:9068941
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin 1A JBrowse link NW_004936501 12,338,542 12,344,236 RGD:9068941
G Rab27a RAB27A, member RAS oncogene family JBrowse link NW_004936471 16,738,204 16,815,561 RGD:9068941
G Unc13d unc-13 homolog D JBrowse link NW_004936594 1,008,215 1,023,023 RGD:9068941
G Vamp2 vesicle associated membrane protein 2 JBrowse link NW_004936595 1,385,692 1,389,484 RGD:9068941
G Vamp7 vesicle associated membrane protein 7 JBrowse link NW_004936958 345,055 393,384 RGD:9068941
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin beta 2 JBrowse link NW_004936677 3,173,054 3,181,475 RGD:9068941
G Clec12b C-type lectin domain family 12 member B JBrowse link NW_004936902 520,825 528,181 RGD:9068941
G Crk CRK proto-oncogene, adaptor protein JBrowse link NW_004936538 7,581,453 7,609,543 RGD:9068941
G Lgals9 galectin 9 JBrowse link NW_004936538 4,034,467 4,050,240 RGD:9068941
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link NW_004936706 37,480 53,306 RGD:9068941
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link NW_004936515 6,001,324 6,015,407 RGD:9068941
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link NW_004936475 21,983,248 22,063,133 RGD:9068941
G Cd160 CD160 molecule JBrowse link NW_004936867 478,625 485,905 RGD:9068941
G Lamp1 lysosomal associated membrane protein 1 JBrowse link NW_004936472 377,359 389,121 RGD:9068941
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link NW_004936475 21,983,248 22,063,133 RGD:9068941
G Cadm1 cell adhesion molecule 1 JBrowse link NW_004936542 569,739 883,738 RGD:9068941
G Cd160 CD160 molecule JBrowse link NW_004936867 478,625 485,905 RGD:9068941
G Crtam cytotoxic and regulatory T cell molecule JBrowse link NW_004936542 7,402,879 7,411,510 RGD:9068941
G Il12a interleukin 12A JBrowse link NW_004936519 6,166,060 6,180,652 RGD:9068941
G Il18rap interleukin 18 receptor accessory protein JBrowse link NW_004936713 1,087,884 1,115,512 RGD:9068941
G Il21 interleukin 21 JBrowse link NW_004936662 1,689,879 1,696,883 RGD:9068941
G Lag3 lymphocyte activating 3 JBrowse link NW_004936709 1,041,519 1,048,630 RGD:9068941
G Lamp1 lysosomal associated membrane protein 1 JBrowse link NW_004936472 377,359 389,121 RGD:9068941
G LOC101976242 NKG2-D type II integral membrane protein JBrowse link NW_004936902 216,495 229,150 RGD:9068941
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link NW_004936727 1,921,452 1,924,395 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004936706 1,470,910 1,498,986 RGD:9068941
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link NW_004936471 2,152,231 2,222,260 RGD:9068941
G Sh2d1a SH2 domain containing 1A JBrowse link NW_004936479 6,258,953 6,281,552 RGD:9068941
G Slamf6 SLAM family member 6 JBrowse link NW_004936740 155,268 165,536 RGD:9068941
G Stat5b signal transducer and activator of transcription 5B JBrowse link NW_004936490 17,022,268 17,043,751 RGD:9068941
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link NW_004936588 4,058,312 4,107,330 RGD:9068941
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crtam cytotoxic and regulatory T cell molecule JBrowse link NW_004936542 7,402,879 7,411,510 RGD:9068941
G Il12a interleukin 12A JBrowse link NW_004936519 6,166,060 6,180,652 RGD:9068941
G Il12b interleukin 12B JBrowse link NW_004936515 4,056,214 4,066,121 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004936706 1,470,910 1,498,986 RGD:9068941
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link NW_004936479 15,394,966 15,411,334 RGD:9068941
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 JBrowse link NW_004936595 1,953,372 1,983,765 RGD:9068941
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link NW_004936542 569,739 883,738 RGD:9068941
G Nectin2 nectin cell adhesion molecule 2 JBrowse link NW_004936706 1,470,910 1,498,986 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14835
    cellular process 14230
      cell killing 133
        leukocyte mediated cytotoxicity 78
          natural killer cell mediated cytotoxicity 39
            natural killer cell degranulation + 8
            natural killer cell mediated cytotoxicity directed against tumor cell target + 6
            negative regulation of natural killer cell mediated cytotoxicity + 6
            positive regulation of natural killer cell mediated cytotoxicity + 18
            regulation of natural killer cell mediated cytotoxicity + 26
Path 2
Term Annotations click to browse term
  biological_process 14835
    response to stimulus 7845
      response to external stimulus 2460
        response to external biotic stimulus 1172
          response to other organism 1170
            defense response to other organism 853
              innate immune response 684
                natural killer cell mediated immunity 43
                  natural killer cell mediated cytotoxicity 39
                    natural killer cell degranulation + 8
                    natural killer cell mediated cytotoxicity directed against tumor cell target + 6
                    negative regulation of natural killer cell mediated cytotoxicity + 6
                    positive regulation of natural killer cell mediated cytotoxicity + 18
                    regulation of natural killer cell mediated cytotoxicity + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.