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ONTOLOGY REPORT - ANNOTATIONS


Term:fat-soluble vitamin biosynthetic process
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Accession:GO:0042362 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.
Synonyms:exact_synonym: fat-soluble vitamin anabolism;   fat-soluble vitamin biosynthesis;   fat-soluble vitamin formation;   fat-soluble vitamin synthesis


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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 IDA
IBA
(PMID:15465040)
(PMID:21873635)
UniProt
GO_Central
PMID:15465040, PMID:21873635 NCBI chr 2:218,781,733...218,815,293
Ensembl chr 2:218,781,749...218,815,293
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 IDA
IBA
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
(PMID:21873635)
UniProt
GO_Central
PMID:9415400, PMID:15795327, PMID:16549446, PMID:17023519, PMID:21873635, PMID:22862690 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986
JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 IDA (PMID:15465040), (PMID:18511070) UniProt PMID:15465040, PMID:18511070 NCBI chr11:14,877,440...14,898,915
Ensembl chr11:14,877,440...14,892,252
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 IEA GOC GO_REF:0000108 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 IDA (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986
JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor IDA (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 IDA (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GFI1 growth factor independent 1 transcriptional repressor IC (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 IC (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G SNAI1 snail family transcriptional repressor 1 IDA (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 IDA (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278, PMID:19502595 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
positive regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma IDA (PMID:9282826) BHF-UCL PMID:9282826 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta IDA (PMID:16720713), (PMID:17023519) BHF-UCL PMID:16720713, PMID:17023519 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G TNF tumor necrosis factor IDA (PMID:1690216) BHF-UCL PMID:1690216 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma IDA (PMID:9282826) BHF-UCL PMID:9282826 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G TNF tumor necrosis factor IDA (PMID:1690216) BHF-UCL PMID:1690216 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VDR vitamin D receptor ISS BHF-UCL GO_REF:0000024 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
vitamin A biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCO1 beta-carotene oxygenase 1 NAS (PMID:15983114) BHF-UCL PMID:15983114 NCBI chr16:81,238,448...81,291,142
Ensembl chr16:81,238,689...81,291,142
JBrowse link
vitamin E biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLTP phospholipid transfer protein IEA Ensembl GO_REF:0000107 NCBI chr20:45,898,620...45,912,155
Ensembl chr20:45,898,621...45,912,155
JBrowse link
vitamin K biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBIAD1 UbiA prenyltransferase domain containing 1 IMP
IBA
IDA
(PMID:23169578)
(PMID:21873635)
(PMID:20953171)
UniProtKB
GO_Central
PMID:20953171, PMID:21873635, PMID:23169578 NCBI chr 1:11,273,198...11,299,574
Ensembl chr 1:11,273,198...11,296,049
Ensembl chr 1:11,273,198...11,296,049
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18626
    metabolic process 12276
      small molecule metabolic process 2139
        vitamin metabolic process 140
          fat-soluble vitamin metabolic process 49
            fat-soluble vitamin biosynthetic process 15
              vitamin A biosynthetic process 1
              vitamin D biosynthetic process + 12
              vitamin E biosynthetic process + 1
              vitamin K biosynthetic process 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.