Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:tumor necrosis factor biosynthetic process
go back to main search page
Accession:GO:0042533 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
Comment:Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
Synonyms:exact_synonym: TNF alpha biosynthesis;   TNF alpha biosynthetic process;   TNF biosynthesis;   TNF biosynthetic process;   Tumor Necrosis Factor alpha biosynthesis;   Tumor Necrosis Factor alpha biosynthetic process;   tumor necrosis factor anabolism;   tumor necrosis factor biosynthesis;   tumor necrosis factor formation;   tumor necrosis factor synthesis


show annotations for term's descendants       view all columns           Sort by:
 
negative regulation of tumor necrosis factor biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:9685562
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1624291
RGD:1600115
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:1624291
RGD:1600115
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1598631
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
positive regulation of tumor necrosis factor biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Akap12 A-kinase anchoring protein 12 JBrowse link 1 40,816,130 40,906,582 RGD:14348968
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1600115
RGD:1624291
G Ccr2 C-C motif chemokine receptor 2 RGD:1624291
RGD:1600115
G Clec4m C-type lectin domain family 4 member M JBrowse link 12 2,817,633 2,826,303 RGD:1624291
RGD:1600115
G Clec7a C-type lectin domain containing 7A JBrowse link 4 163,216,152 163,227,367 RGD:1624291
RGD:1600115
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:11040691
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:1624291
RGD:1600115
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1600115
RGD:1624291
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:1624291
RGD:13792537
RGD:1600115
G Mapkapk2 MAPK activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:1624291
RGD:1600115
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
RGD:1600115
G Spn sialophorin JBrowse link 1 198,572,999 198,585,664 RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tnfrsf8 TNF receptor superfamily member 8 JBrowse link 5 163,186,349 163,231,578 RGD:1624291
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:1624291
regulation of tumor necrosis factor biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Card9 caspase recruitment domain family, member 9 JBrowse link 3 3,798,346 3,806,841 RGD:1624291
RGD:1600115
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:1600115
RGD:1624291
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 JBrowse link 5 48,274,387 48,292,699 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    multicellular organismal process 8585
      cytokine production 783
        cytokine biosynthetic process 116
          tumor necrosis factor biosynthetic process 31
            negative regulation of tumor necrosis factor biosynthetic process 6
            positive regulation of tumor necrosis factor biosynthetic process 22
            regulation of tumor necrosis factor biosynthetic process + 31
Path 2
Term Annotations click to browse term
  biological_process 18008
    metabolic process 10729
      organic substance metabolic process 10177
        organonitrogen compound metabolic process 6369
          protein metabolic process 5543
            cytokine metabolic process 120
              cytokine biosynthetic process 116
                tumor necrosis factor biosynthetic process 31
                  negative regulation of tumor necrosis factor biosynthetic process 6
                  positive regulation of tumor necrosis factor biosynthetic process 22
                  regulation of tumor necrosis factor biosynthetic process + 31
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.