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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of tumor necrosis factor biosynthetic process
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Accession:GO:0042536 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
Comment:Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
Synonyms:exact_synonym: down regulation of tumor necrosis factor biosynthetic process;   downregulation of tumor necrosis factor biosynthetic process;   negative regulation of TNF alpha biosynthesis;   negative regulation of TNF alpha biosynthetic process;   negative regulation of TNF biosynthesis;   negative regulation of TNF biosynthetic process;   negative regulation of tumor necrosis factor anabolism;   negative regulation of tumor necrosis factor biosynthesis;   negative regulation of tumor necrosis factor formation;   negative regulation of tumor necrosis factor synthesis;   negative regulation of tumor necrosis factor-alpha biosynthesis;   negative regulation of tumor necrosis factor-alpha biosynthetic process
 narrow_synonym: inhibition of tumor necrosis factor biosynthetic process


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negative regulation of tumor necrosis factor biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:9685562
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1624291
RGD:1600115
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:1624291
RGD:1600115
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1598631
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18008
    negative regulation of biological process 5407
      negative regulation of multicellular organismal process 1350
        negative regulation of cytokine production 271
          negative regulation of cytokine biosynthetic process 31
            negative regulation of tumor necrosis factor biosynthetic process 6
Path 2
Term Annotations click to browse term
  biological_process 18008
    metabolic process 10729
      organic substance metabolic process 10177
        macromolecule metabolic process 8720
          protein metabolic process 5543
            cytokine metabolic process 120
              cytokine biosynthetic process 116
                regulation of cytokine biosynthetic process 105
                  negative regulation of cytokine biosynthetic process 31
                    negative regulation of tumor necrosis factor biosynthetic process 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.