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ONTOLOGY REPORT - ANNOTATIONS


Term:fear response
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Accession:GO:0042596 term browser browse the term
Definition:The response of an organism to a perceived external threat.
Synonyms:exact_synonym: physiological fear response
 alt_id: GO:0001663


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fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A ISO (MGI:MGI:3039992|PMID:15105370) RGD PMID:15105370 MGI:MGI:3039992 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 ISO
IEA
(MGI:MGI:3040004|PMID:15066288)
GO_REF:0000107
RGD
Ensembl
PMID:15066288 GO_REF:0000107, MGI:MGI:3040004 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO MGI:MGI:2176750 (MGI:MGI:3047468|PMID:15249684) RGD PMID:15249684 MGI:MGI:3047468 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO MGI:MGI:2179732 (MGI:MGI:1858676|PMID:10801976) RGD PMID:10801976 MGI:MGI:1858676 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO (MGI:MGI:1267130|PMID:9655498) RGD PMID:9655498 MGI:MGI:1267130 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Dbh dopamine beta-hydroxylase ISO
IEA
MGI:MGI:1857556 (MGI:MGI:3040004|PMID:15066288)
GO_REF:0000107
RGD
Ensembl
PMID:15066288 GO_REF:0000107, MGI:MGI:3040004 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Drd4 dopamine receptor D4 ISO
IEA
MGI:MGI:2178631 (MGI:MGI:3040118|PMID:11860516)
GO_REF:0000107
RGD
Ensembl
PMID:11860516 GO_REF:0000107, MGI:MGI:3040118 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Ext1 exostosin glycosyltransferase 1 ISO
IEA
(MGI:MGI:5315031|PMID:22411800)
GO_REF:0000107
RGD
Ensembl
PMID:22411800 GO_REF:0000107, MGI:MGI:5315031 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO (MGI:MGI:3689798|PMID:16157280) RGD PMID:16157280 MGI:MGI:3689798 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:17641738 RGD:2325286 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 ISO MGI:MGI:3522476 (MGI:MGI:3588008|PMID:16107644) RGD PMID:16107644 MGI:MGI:3588008 NCBI chr 9:65,961,361...66,034,396
Ensembl chr 9:65,961,346...66,033,871
JBrowse link
G Ankfn1 ankyrin-repeat and fibronectin type III domain containing 1 ISO
IEA
MGI:MGI:2183465 (MGI:MGI:5642309|PMID:26131556)
GO_REF:0000107
RGD
Ensembl
PMID:26131556 GO_REF:0000107, MGI:MGI:5642309 NCBI chr10:76,901,681...77,210,042
Ensembl chr10:76,903,325...76,930,631
JBrowse link
G Asic1 acid sensing ion channel subunit 1 ISO (MGI:MGI:6108223|PMID:25828470) RGD PMID:25828470 MGI:MGI:6108223 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 ISO
IEA
(MGI:MGI:6108223|PMID:25828470)
GO_REF:0000107
RGD
Ensembl
PMID:25828470 GO_REF:0000107, MGI:MGI:6108223 NCBI chr 9:82,647,071...82,668,920
Ensembl chr 9:82,647,071...82,668,920
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 ISO (MGI:MGI:2664023|PMID:12805306) RGD PMID:12805306 MGI:MGI:2664023 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO
IEA
MGI:MGI:1857430 (MGI:MGI:3692132|PMID:16095731)
GO_REF:0000107
RGD
Ensembl
PMID:16095731 GO_REF:0000107, MGI:MGI:3692132 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO MGI:MGI:2176750 (MGI:MGI:3047468|PMID:15249684) RGD PMID:15249684 MGI:MGI:3047468 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Brinp1 BMP/retinoic acid inducible neural specific 1 ISO
IEA
MGI:MGI:5698819 (MGI:MGI:5638841|PMID:24528488)
GO_REF:0000107
RGD
Ensembl
PMID:24528488 GO_REF:0000107, MGI:MGI:5638841 NCBI chr 5:84,919,416...85,123,828
Ensembl chr 5:84,919,367...85,123,829
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO MGI:MGI:2451031 (MGI:MGI:2450008|PMID:11854466) RGD PMID:11854466 MGI:MGI:2450008 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein ISO (MGI:MGI:3717553|PMID:17150371) RGD PMID:17150371 MGI:MGI:3717553 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Deaf1 DEAF1 transcription factor IEA
ISO
GO_REF:0000107
(MGI:MGI:5576037|PMID:24726472)
Ensembl
RGD
PMID:24726472 GO_REF:0000107, MGI:MGI:5576037 NCBI chr 1:214,283,787...214,317,466
Ensembl chr 1:214,283,790...214,317,466
JBrowse link
G Dpp4 dipeptidylpeptidase 4 ISO MGI:MGI:2150161 (MGI:MGI:3640750|PMID:16712972) RGD PMID:16712972 MGI:MGI:3640750 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Drd1 dopamine receptor D1 IEA
ISO
GO_REF:0000107
MGI:MGI:1857158 (MGI:MGI:1930467|PMID:11172752)
Ensembl
RGD
PMID:11172752 GO_REF:0000107, MGI:MGI:1930467 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd4 dopamine receptor D4 IMP RGD PMID:16708027 RGD:1600974 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO MGI:MGI:1270849|MGI:MGI:2384784 (MGI:MGI:5581747|PMID:24990923) RGD PMID:24990923 MGI:MGI:5581747 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 ISO MGI:MGI:1270849|MGI:MGI:95305 (MGI:MGI:5581747|PMID:24990923) RGD PMID:24990923 MGI:MGI:5581747 NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524
JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:15514081 RGD:1582265 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fbxl20 F-box and leucine-rich repeat protein 20 ISO
IEA
MGI:MGI:3765911 (MGI:MGI:4948372|PMID:21390313)
GO_REF:0000107
RGD
Ensembl
PMID:21390313 GO_REF:0000107, MGI:MGI:4948372 NCBI chr10:86,036,745...86,099,699
Ensembl chr10:86,043,235...86,098,694
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 ISO MGI:MGI:2183170 (MGI:MGI:2181457|PMID:12084936) RGD PMID:12084936 MGI:MGI:2181457 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gng7 G protein subunit gamma 7 ISO MGI:MGI:2451322 (MGI:MGI:2450485|PMID:12488442) RGD PMID:12488442 MGI:MGI:2450485 NCBI chr 7:11,565,740...11,629,519
Ensembl chr 7:11,582,984...11,628,929
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 ISO MGI:MGI:1857979 (MGI:MGI:3577154|PMID:15673679) RGD PMID:15673679 MGI:MGI:3577154 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO
IMP
MGI:MGI:3701351 (MGI:MGI:3701026|PMID:16710293) RGD PMID:16710293, PMID:21285873 MGI:MGI:3701026, RGD:13210750 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grm7 glutamate metabotropic receptor 7 NOT ISO MGI:MGI:1857984 (MGI:MGI:1329257|PMID:9920659)
(PMID:17167337)
RGD PMID:9920659, PMID:17167337 MGI:MGI:1329257 NCBI chr 4:142,452,616...143,368,460
Ensembl chr 4:142,780,987...143,367,578
JBrowse link
G Hcrt hypocretin neuropeptide precursor NAS RGD PMID:14614918 RGD:1358373 NCBI chr10:88,669,216...88,670,430
Ensembl chr10:88,669,214...88,670,430
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO
ISS
(MGI:MGI:1314969|PMID:9826725)
GO_REF:0000024
RGD
UniProt
PMID:9826725 GO_REF:0000024, MGI:MGI:1314969 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO
ISS
(MGI:MGI:3798744|PMID:17451451)
GO_REF:0000024
RGD
UniProt
PMID:17451451 GO_REF:0000024, MGI:MGI:3798744 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Kalrn kalirin, RhoGEF kinase ISO MGI:MGI:3831292 (MGI:MGI:3821420|PMID:19020030) RGD PMID:19020030 MGI:MGI:3821420 NCBI chr11:69,484,293...70,025,682
Ensembl chr11:69,484,293...70,025,633
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 ISO MGI:MGI:3840549 (MGI:MGI:3838433|PMID:19246390) RGD PMID:19246390 MGI:MGI:3838433 NCBI chr13:42,219,884...42,263,024
Ensembl chr13:42,219,887...42,263,024
JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO (MGI:MGI:4849330|PMID:21048139) RGD PMID:21048139 MGI:MGI:4849330 NCBI chr 7:130,430,588...130,440,838
Ensembl chr 7:130,431,213...130,440,703
JBrowse link
G Mdk midkine ISO (MGI:MGI:2178952|PMID:10096022) RGD PMID:10096022 MGI:MGI:2178952 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mecp2 methyl CpG binding protein 2 IEA
ISO
GO_REF:0000107
MGI:MGI:2158353|MGI:MGI:2176754|MGI:MGI:3800596 (MGI:MGI:3663583|PMID:16199017), (MGI:MGI:3800599|PMID:16467389)
Ensembl
RGD
PMID:16199017, PMID:16467389 GO_REF:0000107, MGI:MGI:3663583, MGI:MGI:3800599 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Morc1 MORC family CW-type zinc finger 1 ISO MGI:MGI:1857787 (MGI:MGI:5700272|PMID:26275923) RGD PMID:26275923 MGI:MGI:5700272 NCBI chr11:54,762,654...55,044,581
Ensembl chr11:54,762,654...55,044,581
JBrowse link
G Neurod2 neuronal differentiation 2 ISO MGI:MGI:2385828 (MGI:MGI:3607640|PMID:16203979) RGD PMID:16203979 MGI:MGI:3607640 NCBI chr10:86,280,865...86,282,681
Ensembl chr10:86,280,892...86,282,693
JBrowse link
G Npy2r neuropeptide Y receptor Y2 IMP RGD PMID:11830176 RGD:633496 NCBI chr 2:181,528,949...181,538,145
Ensembl chr 2:181,530,832...181,531,978
JBrowse link
G Nr2e1 nuclear receptor subfamily 2, group E, member 1 ISO MGI:MGI:2151350 (MGI:MGI:3527227|PMID:12527005) RGD PMID:12527005 MGI:MGI:3527227 NCBI chr20:47,286,843...47,306,318
Ensembl chr20:47,288,137...47,306,318
JBrowse link
G Pde8b phosphodiesterase 8B ISO (MGI:MGI:5525232|PMID:22925203) RGD PMID:22925203 MGI:MGI:5525232 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Penk proenkephalin ISO MGI:MGI:2388020 (MGI:MGI:1930841|PMID:11172058) RGD PMID:11172058 MGI:MGI:1930841 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO MGI:MGI:2384784|MGI:MGI:95305 (MGI:MGI:5581747|PMID:24990923) RGD PMID:24990923 MGI:MGI:5581747 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Spire1 spire-type actin nucleation factor 1 ISO MGI:MGI:4310183 (MGI:MGI:5698045|PMID:24345451) RGD PMID:24345451 MGI:MGI:5698045 NCBI chr18:63,226,557...63,357,420
Ensembl chr18:63,226,557...63,357,298
JBrowse link
G Taar4 trace amine-associated receptor 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:22,558,787...22,559,830
Ensembl chr 1:22,558,787...22,559,830
JBrowse link
G Usp46 ubiquitin specific peptidase 46 ISO MGI:MGI:5438668 (MGI:MGI:5438429|PMID:22720038) RGD PMID:22720038 MGI:MGI:5438429 NCBI chr14:36,687,134...36,755,360
Ensembl chr14:36,687,134...36,755,360
JBrowse link
G Vdac1 voltage-dependent anion channel 1 ISO MGI:MGI:2182154 (MGI:MGI:2180416|PMID:11907043) RGD PMID:11907043 MGI:MGI:2180416 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdac3 voltage-dependent anion channel 3 ISO
IEA
MGI:MGI:2182182 (MGI:MGI:2180416|PMID:11907043)
GO_REF:0000107
RGD
Ensembl
PMID:11907043 GO_REF:0000107, MGI:MGI:2180416 NCBI chr16:74,292,466...74,308,910
Ensembl chr16:74,292,438...74,308,903
JBrowse link
negative regulation of behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin IMP RGD PMID:12450740 RGD:1626100 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
positive regulation of behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin IDA RGD PMID:12373548 RGD:1358453 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cckbr cholecystokinin B receptor IMP RGD PMID:12373548 RGD:1358453 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Crh corticotropin releasing hormone IDA RGD PMID:10366634 RGD:5508167 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Gja1 gap junction protein, alpha 1 IMP RGD PMID:22665389 RGD:7207267 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Mef2c myocyte enhancer factor 2C IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:5284763|PMID:18579729)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18579729 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5284763 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Npas2 neuronal PAS domain protein 2 ISO (MGI:MGI:6282961|PMID:29163035) RGD PMID:29163035 MGI:MGI:6282961 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Penk proenkephalin IMP RGD PMID:23368426 RGD:10040949 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Ucn urocortin IDA RGD PMID:10366634 RGD:5508167 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
regulation of behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
IEA
(PMID:24412220)
GO_REF:0000107
RGD
Ensembl
PMID:24412220 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Rag1 recombination activating 1 IMP RGD PMID:22964459 RGD:12907572 NCBI chr 3:91,206,394...91,217,491
Ensembl chr 3:91,206,394...91,217,491
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 ISO
IEA
ISS
(MGI:MGI:4948759|PMID:21423165)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:21423165 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4948759 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    multicellular organismal process 9056
      multicellular organismal response to stress 107
        fear response 59
          behavioral fear response + 54
          negative regulation of fear response + 1
          positive regulation of fear response + 8
          regulation of fear response + 11
Path 2
Term Annotations click to browse term
  biological_process 20015
    response to stimulus 10570
      response to stress 4060
        multicellular organismal response to stress 107
          fear response 59
            behavioral fear response + 54
            negative regulation of fear response + 1
            positive regulation of fear response + 8
            regulation of fear response + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.