Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction in response to DNA damage
go back to main search page
Accession:GO:0042770 term browser browse the term
Definition:A cascade of processes induced by the detection of DNA damage within a cell.
Synonyms:exact_synonym: DNA damage response, signal transduction;   response to DNA damage stimulus by intracellular signaling cascade


show annotations for term's descendants       view all columns           Sort by:
 
signal transduction in response to DNA damage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 10 67,427,042 67,475,825 RGD:1624291
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:1624291
G Cep63 centrosomal protein 63 JBrowse link 8 111,063,988 111,116,014 RGD:1600115
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
RGD:13792537
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:1624291
RGD:1600115
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1624291
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1624291
RGD:1600115
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:13792537
G Stk33 serine/threonine kinase 33 JBrowse link 1 173,872,744 174,051,768 RGD:13792537
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acer2 alkaline ceramidase 2 JBrowse link 5 105,230,540 105,279,732 RGD:1624291
G Atrx ATRX, chromatin remodeler JBrowse link X 76,820,110 76,979,155 RGD:1600115
RGD:1624291
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1624291
RGD:1600115
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G E2f7 E2F transcription factor 7 JBrowse link 7 53,275,659 53,318,261 RGD:1624291
RGD:1600115
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:1624291
G Mdm4 MDM4 regulator of p53 JBrowse link 13 49,786,776 49,828,780 RGD:1624291
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:1624291
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:1624291
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:1624291
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:1624291
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:1624291
G Usp10 ubiquitin specific peptidase 10 JBrowse link 19 52,566,274 52,608,820 RGD:1624291
RGD:13792537
RGD:1600115
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 7 36,395,665 36,408,588 RGD:1624291
RGD:13792537
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:1624291
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
G Sox4 SRY-box transcription factor 4 JBrowse link 17 37,615,022 37,619,728 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1624291
RGD:1600115
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:1600115
RGD:1624291
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
G Ing4 inhibitor of growth family, member 4 JBrowse link 4 157,554,729 157,563,353 RGD:1624291
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:1600115
RGD:1624291
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:1624291
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:1624291
G Sp100 SP100 nuclear antigen JBrowse link 9 92,675,103 92,718,489 RGD:1624291
G Tfap4 transcription factor AP-4 JBrowse link 10 11,204,616 11,222,975 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
DNA damage response, signal transduction resulting in transcription term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1624291
RGD:1600115
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1624291
RGD:1600115
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:1600115
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:1624291
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 JBrowse link 13 47,906,230 47,916,877 RGD:1600115
RGD:1624291
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:1624291
G Marchf7 membrane associated ring-CH-type finger 7 JBrowse link 3 46,284,961 46,325,230 RGD:1624291
RGD:1600115
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:1624291
RGD:1600115
G Pttg1ip PTTG1 interacting protein JBrowse link 20 11,746,369 11,764,097 RGD:1624291
G Senp2 SUMO specific peptidase 2 JBrowse link 11 82,627,973 82,664,702 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pcbp4 poly(rC) binding protein 4 JBrowse link 8 115,154,848 115,165,706 RGD:1624291
positive regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ankrd1 ankyrin repeat domain 1 JBrowse link 1 254,726,985 254,745,673 RGD:1624291
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Ddx5 DEAD-box helicase 5 JBrowse link 10 94,979,759 94,988,461 RGD:1624291
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 JBrowse link 17 26,785,017 26,795,723 RGD:1624291
G Hic1 HIC ZBTB transcriptional repressor 1 JBrowse link 10 62,007,150 62,010,774 RGD:1624291
G Pla2r1 phospholipase A2 receptor 1 JBrowse link 3 46,488,963 46,621,873 RGD:1624291
RGD:1600115
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:13792537
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:1624291
RGD:13792537
RGD:1600115
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:13792537
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
G Zfp385a zinc finger protein 385A JBrowse link 7 144,939,616 144,966,364 RGD:1624291
regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kmt5a lysine methyltransferase 5A JBrowse link 12 37,558,150 37,581,183 RGD:1624291
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:1624291
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:1624291
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:1624291
RGD:13792537
signal transduction involved in DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:1624291
RGD:1600115
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
RGD:1600115
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291
signal transduction involved in G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abraxas1 abraxas 1, BRCA1 A complex subunit JBrowse link 14 10,424,674 10,439,010 RGD:1600115
RGD:1624291
G Babam1 BRISC and BRCA1 A complex member 1 JBrowse link 16 19,792,720 19,798,886 RGD:1600115
RGD:1624291
G Babam2 BRISC and BRCA1 A complex member 2 JBrowse link 6 25,666,654 26,135,888 RGD:1624291
RGD:1600115
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1600115
RGD:1624291
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:1600115
RGD:1624291
G Cdc14b cell division cycle 14B JBrowse link 17 1,709,703 1,797,732 RGD:1624291
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:1624291
G Dtl denticleless E3 ubiquitin protein ligase homolog JBrowse link 13 110,219,276 110,257,345 RGD:1624291
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:1624291
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:1600115
RGD:1624291
G Uimc1 ubiquitin interaction motif containing 1 JBrowse link 17 10,061,915 10,130,921 RGD:1600115
RGD:1624291
signal transduction involved in intra-S DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
signal transduction involved in mitotic G1 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:1624291
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      signal transduction 6872
        intracellular signal transduction 2584
          signal transduction in response to DNA damage 95
            DNA damage response, signal transduction by p53 class mediator + 68
            DNA damage response, signal transduction resulting in transcription + 18
            signal transduction involved in DNA damage checkpoint + 30
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11995
          signal transduction 6872
            intracellular signal transduction 2584
              signal transduction in response to DNA damage 95
                DNA damage response, signal transduction by p53 class mediator + 68
                DNA damage response, signal transduction resulting in transcription + 18
                signal transduction involved in DNA damage checkpoint + 30
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.