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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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Accession:GO:0042771 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease ISO
IBA
ISS
(PMID:18264133)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:18264133, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:MGI:1336991|MGI:MGI:98834 (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Bag6 BAG cochaperone 6 ISO
ISS
(PMID:17403783)
GO_REF:0000024
RGD
UniProt
PMID:17403783 GO_REF:0000024 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO MGI:MGI:2681654 (MGI:MGI:3603103|PMID:16151013) RGD PMID:16151013 MGI:MGI:3603103 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl3 BCL3, transcription coactivator ISO (PMID:16384933) RGD PMID:16384933 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Brca2 BRCA2, DNA repair associated IEA
ISO
GO_REF:0000107
MGI:MGI:2429691|MGI:MGI:3052655|MGI:MGI:98834 (MGI:MGI:3579926|PMID:15735671), (MGI:MGI:3714678|PMID:17476307)
Ensembl
RGD
PMID:15735671, PMID:17476307 GO_REF:0000107, MGI:MGI:3579926, MGI:MGI:3714678 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Cdip1 cell death-inducing p53 target 1 ISO (PMID:17599062) RGD PMID:17599062 NCBI chr10:10,966,819...10,989,937
Ensembl chr10:10,967,658...10,989,936
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO MGI:MGI:1933751 (MGI:MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:MGI:2675761 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek2 checkpoint kinase 2 ISO MGI:MGI:2386905 (MGI:MGI:1354114|PMID:10710310) RGD PMID:10710310 MGI:MGI:1354114 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5298149|PMID:21896779)
Ensembl
UniProt
RGD
PMID:21896779 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5298149 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 ISO (PMID:17349958) RGD PMID:17349958 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Ep300 E1A binding protein p300 ISO (PMID:17403783) RGD PMID:17403783 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 ISO
IBA
IEA
MGI:MGI:1314872|MGI:MGI:98834 (MGI:MGI:3619785|PMID:16537918)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:16537918, PMID:21873635 GO_REF:0000107, MGI:MGI:3619785, RGD:13792537 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO
IBA
MGI:MGI:1314872|MGI:MGI:98834 (MGI:MGI:3619785|PMID:16537918)
PMID:21873635
RGD PMID:16537918, PMID:21873635 MGI:MGI:3619785, RGD:13792537 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Msh2 mutS homolog 2 ISO
IBA
IEA
MGI:MGI:98834 (MGI:MGI:1334080|PMID:10097137)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:10097137, PMID:21873635 GO_REF:0000107, MGI:MGI:1334080, RGD:13792537 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator ISO MGI:MGI:3784016 (MGI:MGI:3784021|PMID:11896600) RGD PMID:11896600 MGI:MGI:3784021 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 ISO
IBA
ISS
(PMID:19203586)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19203586, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO (MGI:MGI:1858284|PMID:10807576) RGD PMID:10807576 MGI:MGI:1858284 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:MGI:3580934 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rps27l ribosomal protein S27-like ISO (PMID:17057733), (PMID:18056458) RGD PMID:17057733, PMID:18056458 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Shisa5 shisa family member 5 ISO
IEA
(MGI:MGI:2183272|PMID:12135983)
GO_REF:0000107
RGD
Ensembl
PMID:12135983 GO_REF:0000107, MGI:MGI:2183272 NCBI chr 8:117,780,992...117,795,923
Ensembl chr 8:117,780,891...117,795,919
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:20100829)
GO_REF:0000107
RGD
Ensembl
PMID:20100829 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Snw1 SNW domain containing 1 ISO (PMID:21460037) RGD PMID:21460037 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
JBrowse link
G Tmem109 transmembrane protein 109 ISO
IBA
MGI:MGI:4453832 (MGI:MGI:4437179|PMID:20060811)
PMID:21873635
RGD PMID:20060811, PMID:21873635 MGI:MGI:4437179, RGD:13792537 NCBI chr 1:226,925,114...226,935,710
Ensembl chr 1:226,925,117...226,935,689
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase ISO (MGI:MGI:3578084|PMID:15735665) RGD PMID:15735665 MGI:MGI:3578084 NCBI chr 5:56,554,956...56,566,503
Ensembl chr 5:56,554,969...56,567,320
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:14654789), (PMID:14744935), (PMID:16213212), (PMID:17403783)
MGI:MGI:109337|MGI:MGI:1096393|MGI:MGI:1336991|MGI:MGI:1857263|MGI:MGI:1926340|MGI:MGI:2442925 (MGI:MGI:2183272|PMID:12135983), (MGI:MGI:2675761|PMID:12952892), (MGI:MGI:3584078|PMID:15983387), (MGI:MGI:3652689|PMID:16777961), (MGI:MGI:3690827|PMID:16286009), (MGI:MGI:3714678|PMID:17476307), (MGI:MGI:4944151|PMID:20818388), (MGI:MGI:5882892|PMID:16213212)
RGD PMID:12135983, PMID:12952892, PMID:14654789, PMID:14744935, PMID:15983387, PMID:16213212, PMID:16286009, PMID:16777961, PMID:17403783, PMID:17476307, PMID:20818388 MGI:MGI:2183272, MGI:MGI:2675761, MGI:MGI:3584078, MGI:MGI:3652689, MGI:MGI:3690827, MGI:MGI:3714678, MGI:MGI:4944151, MGI:MGI:5882892 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 ISO MGI:MGI:1934269 (MGI:MGI:3693137|PMID:17122775) RGD PMID:17122775 MGI:MGI:3693137 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 ISO (PMID:18174154), (PMID:19490146) RGD PMID:18174154, PMID:19490146 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Usp28 ubiquitin specific peptidase 28 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16901786)
Ensembl
UniProt
RGD
PMID:16901786 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:53,295,188...53,355,572
Ensembl chr 8:53,295,222...53,355,572
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Bcl2l12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:MGI:4834958 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO
IEA
(PMID:17045821)
GO_REF:0000107
(MGI:MGI:3690285|PMID:17045821)
RGD
Ensembl
PMID:17045821 GO_REF:0000107, MGI:MGI:3690285 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd74 CD74 molecule ISO
IBA
ISS
(MGI:MGI:3690285|PMID:17045821)
PMID:21873635
GO_REF:0000024
(PMID:17045821)
RGD
BHF-UCL
PMID:17045821, PMID:21873635 GO_REF:0000024, MGI:MGI:3690285, RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) RGD PMID:22768269 MGI:MGI:5438719 NCBI chr 3:113,400,395...113,405,869
Ensembl chr 3:113,401,734...113,405,829
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO
ISS
(PMID:29295817)
GO_REF:0000024
RGD
UniProt
PMID:29295817 GO_REF:0000024 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057
JBrowse link
G Mif macrophage migration inhibitory factor ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:2152474|PMID:11672522) RGD PMID:11672522 MGI:MGI:2152474 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:15735003) RGD PMID:15735003 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Zfp385a zinc finger protein 385A ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 ISO (PMID:16213212)
(MGI:MGI:5882892|PMID:16213212)
RGD PMID:16213212 MGI:MGI:5882892 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Steap3 STEAP3 metalloreductase ISO MGI:MGI:4398911 (MGI:MGI:4367682|PMID:18617898) RGD PMID:18617898 MGI:MGI:4367682 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Tp73 tumor protein p73 ISO MGI:MGI:2442925|MGI:MGI:98834 (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpk heterogeneous nuclear ribonucleoprotein K ISO (MGI:MGI:4881379|PMID:20673990) RGD PMID:20673990 MGI:MGI:4881379 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to stress 4059
        cellular response to stress 1992
          cellular response to DNA damage stimulus 783
            intrinsic apoptotic signaling pathway in response to DNA damage 110
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 44
                negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12
                positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3
                regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 16
Path 2
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cell death 2154
        programmed cell death 1968
          apoptotic process 1922
            apoptotic signaling pathway 635
              intrinsic apoptotic signaling pathway 303
                intrinsic apoptotic signaling pathway in response to DNA damage 110
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 44
                    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12
                    positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3
                    regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.