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ONTOLOGY REPORT - ANNOTATIONS


Term:MHC class I peptide loading complex
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Accession:GO:0042824 term browser browse the term
Definition:A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
Comment:Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
Synonyms:exact_synonym: peptide-loading complex
 related_synonym: PLC


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MHC class I peptide loading complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:1600115
RGD:1624291
RGD:13792542
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:13792542
RGD:13792537
RGD:1624291
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:1601415
RGD:13792537
RGD:1624291
RGD:13792542
G Tapbp TAP binding protein JBrowse link 20 5,468,056 5,476,007 RGD:634074
RGD:1624291
RGD:13792542
TAP complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC103689996 antigen peptide transporter 2 JBrowse link 20 5,197,869 5,212,262 RGD:1600115
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:9999147
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:1300480
RGD:1600115
RGD:1624291
RGD:13792542
RGD:2312377
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:2312377
RGD:13792542
RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      membrane protein complex 1210
        MHC class I peptide loading complex 8
          TAP complex 4
          Tapasin-ERp57 complex 0
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          organelle membrane 2679
            endoplasmic reticulum membrane 860
              intrinsic component of endoplasmic reticulum membrane 150
                integral component of endoplasmic reticulum membrane 142
                  MHC class I peptide loading complex 8
                    TAP complex 4
                    Tapasin-ERp57 complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.