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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein biosynthetic process
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Accession:GO:0042983 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP biosynthesis;   APP biosynthetic process;   amyloid precursor protein anabolism;   amyloid precursor protein biosynthesis;   amyloid precursor protein formation;   amyloid precursor protein synthesis


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amyloid precursor protein biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ncstn nicastrin JBrowse link 13 90,451,046 90,467,256 RGD:1624291
RGD:1600115
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aatf apoptosis antagonizing transcription factor JBrowse link 10 71,744,648 71,837,851 RGD:1624291
RGD:1600115
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:1624291
RGD:1600115
G Ago2 argonaute RISC catalytic component 2 JBrowse link 7 114,339,607 114,377,277 RGD:14390059
G Bace2 beta-secretase 2 JBrowse link 11 37,798,397 37,880,624 RGD:1624291
RGD:1600115
G Itm2a integral membrane protein 2A JBrowse link X 78,490,872 78,496,814 RGD:13792537
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:1600115
RGD:13792537
RGD:1624291
G Itm2c integral membrane protein 2C JBrowse link 9 92,916,469 92,930,306 RGD:13792537
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:1600115
G Ncstn nicastrin JBrowse link 13 90,451,046 90,467,256 RGD:1624291
RGD:1600115
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:1624291
RGD:1600115
G Soat1 sterol O-acyltransferase 1 JBrowse link 13 74,035,258 74,077,759 RGD:1624291
RGD:1600115
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Necab1 N-terminal EF-hand calcium binding protein 1 JBrowse link 5 28,507,596 28,737,556 RGD:13792537
G Necab2 N-terminal EF-hand calcium binding protein 2 JBrowse link 19 52,086,325 52,112,633 RGD:13792537
G Necab3 N-terminal EF-hand calcium binding protein 3 JBrowse link 3 150,047,826 150,062,806 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      biosynthetic process 5464
        organic substance biosynthetic process 5353
          organonitrogen compound biosynthetic process 1645
            amyloid precursor protein biosynthetic process 14
              negative regulation of amyloid precursor protein biosynthetic process 7
              positive regulation of amyloid precursor protein biosynthetic process 4
              regulation of amyloid precursor protein biosynthetic process + 14
Path 2
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      nitrogen compound metabolic process 9243
        organonitrogen compound metabolic process 6419
          protein metabolic process 5590
            amyloid precursor protein metabolic process 61
              amyloid precursor protein biosynthetic process 14
                negative regulation of amyloid precursor protein biosynthetic process 7
                positive regulation of amyloid precursor protein biosynthetic process 4
                regulation of amyloid precursor protein biosynthetic process + 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.