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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


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neurotrophin binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508745
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:13792537
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:8554777
RGD:13792537
RGD:1600115
RGD:1624291
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:13792537
brain-derived neurotrophic factor binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:10046023
G Fstl4 follistatin-like 4 JBrowse link 10 38,104,344 38,532,216 RGD:1624291
G Hap1 huntingtin-associated protein 1 JBrowse link 10 88,257,975 88,266,210 RGD:10047154
RGD:10047187
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:1626130
RGD:13792537
RGD:1624291
RGD:1600115
RGD:8554777
RGD:1626131
G Pzp pregnancy-zone protein JBrowse link 4 161,804,792 161,850,877 RGD:10046023
nerve growth factor binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:10046023
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:1624291
RGD:1600115
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:728964
RGD:1600115
RGD:13792537
RGD:1624291
G Nradd neurotrophin receptor associated death domain JBrowse link 8 118,890,402 118,893,712 RGD:13792537
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:729140
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:5508802
RGD:1624291
RGD:1600115
G Pcsk6 proprotein convertase subtilisin/kexin type 6 JBrowse link 1 126,749,508 126,947,392 RGD:1624291
RGD:1600115
G Pzp pregnancy-zone protein JBrowse link 4 161,804,792 161,850,877 RGD:10046023
G Sort1 sortilin 1 JBrowse link 2 211,078,092 211,156,312 RGD:1624291

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Term Annotations click to browse term
  molecular_function 19528
    binding 15911
      protein binding 12626
        growth factor binding 153
          neurotrophin binding 13
            brain-derived neurotrophic factor binding 5
            nerve growth factor binding 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.